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deCODE and Radboud University Discover Common Variants in the Human Genome Conferring Risk of Bladder Cancer
Date:9/14/2008

Detection may be used to complement and target screening for the disease; findings will be integrated into the deCODEme(TM) personal genome scan.

REYKJAVIK, Iceland, Sept. 14 /PRNewswire-FirstCall/ -- Scientists at deCODE genetics (Nasdaq: DCGN) and colleagues at Radboud University Medical Center in the Netherlands today report the discovery of two common single-letter variants in the human genome (SNPs) that confer increased risk of urinary bladder cancer. Approximately 20% of people of European descent carry two copies of the first variant, a version of a SNP on chromosome 8q24, putting them at a 50% higher risk of developing bladder cancer than those without the variant. Individuals who carry two copies of a common version of another SNP on chromosome 3 were found to be at a 40% higher risk of the disease than non-carriers. These are the best-replicated genetic variants ever linked to bladder cancer risk, and the study analyzed genotypic data from more than 40,000 patients and controls from Iceland, the Netherlands and eight other European countries. The paper, entitled 'Sequence variant on 8q24 confers susceptibility to urinary bladder cancer,' will appear today in the online edition of Nature Genetics at http://www.nature.com/ng.

"In all cancers, the ability to identify individuals at high risk, screening them intensively and intervening early, is the key to improving prevention and outcomes. We expect that the detection of these and other risk variants will soon be employed to complement the assessment of standard risk factors for bladder cancer. As with all of our discovery work, we seek to publish our findings and establish a solid intellectual property position in
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