Navigation Links
deCODE Shows how Genetic Risk of Kidney Disease Frames Response to Environmental Risk Over Time
Date:7/29/2010

REYKJAVIK, Iceland, July 29, 2010 /PRNewswire-FirstCall/ -- Scientists at deCODE genetics and colleagues at Radboud University in the Netherlands today describe how the impact of a single letter variation in the sequence of the human genome (SNP) conferring risk of kidney disease varies with age and with the onset of other diseases. The study provides independent confirmation of the association made in an earlier study between a version of the the SNP, located on chromosome 16p12, and risk of chronic kidney disease (CKD). It also confirmed the link between the SNP and concentrations of serum creatinine (SCr), a key indicator of kidney function. But the deCODE team then used its detailed population-based data in Iceland to go further, demonstrating that the impact of the at-risk version SNP on risk of kidney disease and SCr increases with age and if carriers develop high blood pressure or type 2 diabetes. At the same time, the SNP was shown in a large Icelandic and Dutch case-control cohort to protect against the formation of kidney stones.

"The common diseases happen at the interface between genes and the environment, and this study offers a clear and medically useful example of this dynamic in action. This SNP is now a validated risk factor for kidney disease, but we have also shown how it can be made even more meaningful if looked at in the context of age and broader health history. It is directly adjacent to the gene econding uromodulin, or UMOD, the most abundant protein in human urine. It therefore appears that it confers risk by modulating how the kidneys adapt to age itself and to the accumulation of environmental insults, such as hypertension and diabetes, over time. We believe this mechanism may be a fruitful subject for further research aimed at prevent
'/>"/>

SOURCE DeCODE Genetics Inc
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related medicine technology :

1. deCODE Launches Phase II Clinical Testing of DG051 for the Prevention of Heart Attack
2. deCODE Launches deCODE MI(TM) -- A Test for a Major Genetic Risk Factor for Early-onset Heart Attack
3. deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes
4. deCODE Obesity Study Sheds Light on How Genetics Affects Risk and Onset of Common Diseases
5. deCODE Discovers Novel Genetic Links Between Pigmentation Traits and Risk of Skin Cancer
6. Marketing of Diagnostics and deCODEme(TM), Recent Progress in Drug Development to be Highlighted at deCODE R&D Event
7. deCODE and SGENE Consortium Discover Deletions in the Human Genome Linked to Risk of Schizophrenia
8. deCODE and Radboud University Discover Common Variants in the Human Genome Conferring Risk of Bladder Cancer
9. deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimers and Other Cognitive Disorders
10. Major deCODE-led Study Underscores Role of the Brain in Obesity
11. A Milestone in Cancer Genetics: deCODE Discovers First Common Genetic Variants Affecting the Risk of Many Types of Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... ORLANDO, Fla. , May 18, 2013 ... and are considered the most sensitive method for ... completely effective in preventing cancer cases 3 . EndoChoice ... its new Fuse™ system significantly improves the accuracy of ... missed by colonoscopists. EndoChoice will be discussing these clinical ...
(Date:5/18/2013)... , May 18, 2013 The Open ... , Occupy Psychiatry , and leading ... care, announces a social media campaign showcasing video ... psychiatric model, which focuses on pathology and illness ... with the American Psychiatric Association,s (APA) rollout of ...
(Date:5/18/2013)... , May 18, 2013 Faruqi & ... is investigating potential securities fraud at AVEO Pharmaceuticals, ... (Logo: http://photos.prnewswire.com/prnh/20120119/MM38856LOGO ) ... its executives violated federal securities laws by issuing ... Phase III drug trials for Tivopath (tivozanib) (titled ...
Breaking Medicine Technology:New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 2New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 3New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 2New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 3Faruqi & Faruqi, LLP Encourages Investors Who Suffered Losses In Excess Of $100,000 Investing In AVEO Pharmaceuticals, Inc. To Contact The Firm 2
... safety data from VELOUR, the pivotal Phase III trial ... metastatic colorectal cancer (mCRC) will be presented by Edith ... Angiogenesis Foundation,s 9th Annual M. Judah Folkman International Conference: ... 2011 at the Hyatt Regency Cambridge. The ...
... Inc. (NYSE Amex: PIP ) today announced ... in the Delaware Court of Chancery. PharmAthene filed the ... in ST-246, an orally available smallpox antiviral drug candidate. ... decision," remarked Eric I. Richman, President and Chief Executive ...
Cached Medicine Technology:Efficacy Data from Phase III VELOUR Trial in Colorectal Cancer to be Presented at Angiogenesis Foundation's 2011 M. Judah Folkman International Conference in Cambridge, Mass. 2PharmAthene Awarded 50% Profit Split on Worldwide Sales of Smallpox Antiviral Therapy by Delaware Chancery Court 2PharmAthene Awarded 50% Profit Split on Worldwide Sales of Smallpox Antiviral Therapy by Delaware Chancery Court 3
(Date:5/18/2013)... TheBeautyPlace.com answers important questions about the ... not a result of stress, nutrient deficiency or wearing ... 70% of men suffer from male patterned baldness. ... for hair transplant surgery, but additionally carries a hair ... as Bosley Professional Strength. Their product line is a ...
(Date:5/18/2013)... New York (PRWEB) May 18, 2013 ... mount in courts throughout the country, Bernstein Liebhard LLP ... hip replacement patients often suffer tissue damage before they ... study, which according to Science Daily will appear in ... hip replacement recipients underwent MRI screens of their hips. ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Although obesity ... tumors, the association between obesity and esophageal adenocarcinoma, a ... other obesity-related tumors. As reported on Cancer.gov, ... are almost twice as likely as those of normal ... the relationship between obesity and esophageal cancer is not ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 The “Sleep ... Pulse Oximeters, CPAP, Masks, Adaptive Servo-Ventilation (ASV), Oral Appliances, ... Forecast to 2017” analyzes and studies the major market ... and Rest of the World. , Browse , ... 16 Figures , 318 ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Adolescents, especially ... known as “Spice” or “K2” are landing in emergency ... to curb this drug epidemic with a new ... marijuana. , According to research from the National Institute ... popular illegal drug among American teenagers. In 2012, 11 ...
Breaking Medicine News(10 mins):Health News:TheBeautyPlace.com Features the Two New Best-Selling Hairloss Products: Bosley Professional Strength and Nioxin Systems 2Health News:TheBeautyPlace.com Features the Two New Best-Selling Hairloss Products: Bosley Professional Strength and Nioxin Systems 3Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 2Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 3Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 4Health News:hCGtreatments / Diet Doc Hcg Diets & Weight Loss Plans Announces New Prescription Hcg Diet Plans Designed to Trim Inches and Thus Reduce the Risk of Esophageal Cancer 2Health News:hCGtreatments / Diet Doc Hcg Diets & Weight Loss Plans Announces New Prescription Hcg Diet Plans Designed to Trim Inches and Thus Reduce the Risk of Esophageal Cancer 3Health News:Sleep Apnea Devices Market to reach $19.72 Billion by 2017 - New Report by MarketandMarkets 2Health News:Sleep Apnea Devices Market to reach $19.72 Billion by 2017 - New Report by MarketandMarkets 3Health News:Spice Addiction Treatment and Synthetic Marijuana Drug Rehab Announced by Recovery Associates 2
... initiatives designed to improve the management of rheumatoid arthritis ... the Annual Congress of the European League Against Rheumatism ... impact score , The first, a EULAR initiative entitled ... Impact of Disease, (RAID) score, was based on patients, ...
... Injury Is Key, WASHINGTON, June 13 ... will fly to Germany on Saturday,to work with ... in,assessing their current rehabilitation practices. They will also ... care given to,injured soldiers and other military personnel ...
... Rising Medical Solutions, Inc.,(Rising), a leading medical-financial ... have chosen Bank of America as their ... management offerings., (Logo: http://www.newscom.com/cgi-bin/prnh/20080206/AQW030LOGO-b ), ... America Direct(R) treasury,services as the foundation for ...
... knowledge of safety, privacy, emergency practices, but will leave them ... parents leave their tweens home alone for an extended period ... to 13-year-olds have the knowledge or skills to stay safe, ... C.S. Mott Children,s Hospital National Poll on Children,s Health ...
... EntreMed, Inc.,(Nasdaq: ENMD ) a clinical-stage ... cancer and inflammatory diseases,announced today that James ... present a Company overview during the Business ... International Convention,being held June 17-20, 2008 at ...
... (PAH)chronically high blood pressure in the blood vessels of ... or HN) have a very poor chance of survival ... to new research from the University of Pennsylvania. ... advanced left heart failure but has never been demonstrated ...
Cached Medicine News:Health News:New insight into RA patient priorities and motivators for clinical trial involvement 2Health News:New insight into RA patient priorities and motivators for clinical trial involvement 3Health News:National Rehabilitation Hospital Team to Work with US Army to Improve Rehab Care for Wounded Soldiers 2Health News:National Rehabilitation Hospital Team to Work with US Army to Improve Rehab Care for Wounded Soldiers 3Health News:National Rehabilitation Hospital Team to Work with US Army to Improve Rehab Care for Wounded Soldiers 4Health News:National Rehabilitation Hospital Team to Work with US Army to Improve Rehab Care for Wounded Soldiers 5Health News:Rising Medical Solutions Chooses Bank of America to Bring Enhanced Cash Management and Provider Payment Solutions to the Marketplace 2Health News:Rising Medical Solutions Chooses Bank of America to Bring Enhanced Cash Management and Provider Payment Solutions to the Marketplace 3Health News:Parents Worry About Tweens Left Alone 2Health News:EntreMed to Present at the BIO 2008 Annual International Convention 2Health News:Serum sodium predicts mortality 10 times higher in PAH patients 2
HDL Cholesterol, liquid....
For the quantitative determination of high density lipoprotein (HDL) in human serum....
... Intended for the ... in plasma. Two vials, ... Enzymatic, alphaketoglutarate. Uses NADPH ... other plasma compounds. Reaction: ...
... The Proteomeworks system is an ... technologies that enables protein function ... sample preparation, 2-D electrophoresis, staining, ... excision, automated protein digestion, mass ...
Medicine Products: