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deCODE Launches deCODE MI(TM) -- A Test for a Major Genetic Risk Factor for Early-onset Heart Attack
Date:10/11/2007

ified physician. If you are an individual who would like more information on deCODE MI(TM) to discuss with your doctor, or a physician interested in learning more about deCODE MI(TM) for your patients, please visit us at http://www.decodediagnostics.com.

The variants detected by deCODE MI(TM), are two SNPs (single-letter variants in the genome) on chromosome 9p21. They were discovered by deCODE scientists earlier this year through genome-wide SNP analysis in Iceland and replicated in three cohorts of European descent from Philadelphia, Atlanta and Durham, North Carolina. Of the 17,000 patients and control subjects in the study, more than 20% of participants carried two copies of the variant, corresponding to a more than 60% increase in risk of heart attack, regardless of age of onset, compared to those without the variant. In early-onset cases -- men and women who suffered a heart attack before the ages of 50 and 60, respectively -- carrying two copies of the variant corresponds to an approximate doubling of risk compared to non-carriers. The variant is estimated to account for approximately one-fifth of the incidence of heart attack in populations of European origin, and nearly one third of early-onset cases, making it the one of the most significant genetic risk factors found to date for heart attack as a public health problem.

About deCODE

deCODE is a biopharmaceutical company applying its discoveries in human genetics to the development of drugs and diagnostics for common diseases. deCODE is a global leader in gene discovery -- our population approach and resources have enabled us to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer, genes that are providing us with drug targets rooted in the basic biology of disease. Through its CLIA-certified laboratory, deCODE is offering a growing range of DNA-based tests for gauging risk and em
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