Navigation Links
deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimer's and Other Cognitive Disorders
Date:10/3/2008

REYKJAVIK, Iceland, Oct. 3 /PRNewswire-FirstCall/ -- deCODE genetics (Nasdaq: DCGN) today announced the filing of an investigational new drug (IND) application for DG071, the company's novel small-molecule modulator of phosphodiesterase 4 (PDE4), with the US Food and Drug Administration (FDA). The compound is being developed as a new and potentially safer means of targeting PDE4 to combat memory loss and cognitive deficits associated with Alzheimer's disease and other disorders in which neural signaling is reduced or impaired. In animal models, DG071 has been shown to significantly improve learning and long- and short-term memory at doses that offer a wide margin for safety and tolerability. The compound has the potential to eliminate the nausea that limits the utility of previous PDE4 inhibitors. deCODE plans to advance the clinical development of DG071 with a strategic partner.

"This compound has exciting therapeutic potential and reflects the exceptional capabilities of our drug discovery and structural biology groups. Our teams used protein crytallography to determine the structure of domains that regulate the enzymatic activity of PDE4, and in DG071 discovered a compound that binds to the PDE4 regulatory domain and effectively modulates the activity of the enzyme. DG071 has been shown in several animal models to potently and specifically improve cognitive function, and features a much wider safety and tolerability profile than existing PDE4 inhibitors. This is encouraging, as many of the amyloid-busting therapeutics currently entering clinical trials in Alzheimer's disease have the potential to slow or stop progression of the disease but will not reverse the destruction of neurons. Our expectation is that DG071 will allow the
'/>"/>

SOURCE deCODE genetics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. deCODE and Radboud University Discover Common Variants in the Human Genome Conferring Risk of Bladder Cancer
2. deCODE and SGENE Consortium Discover Deletions in the Human Genome Linked to Risk of Schizophrenia
3. Marketing of Diagnostics and deCODEme(TM), Recent Progress in Drug Development to be Highlighted at deCODE R&D Event
4. deCODE Discovers Novel Genetic Links Between Pigmentation Traits and Risk of Skin Cancer
5. deCODE Obesity Study Sheds Light on How Genetics Affects Risk and Onset of Common Diseases
6. deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes
7. deCODE Launches deCODE MI(TM) -- A Test for a Major Genetic Risk Factor for Early-onset Heart Attack
8. deCODE Launches Phase II Clinical Testing of DG051 for the Prevention of Heart Attack
9. ASX/NASDAQ Media Release: Pharmaxis Files First Marketing Application for Bronchitol in Australia
10. Sound Pharmaceuticals Files Second IND with the FDA for the Prevention of Chemotherapy Induced Hearing Loss in Advanced Stage Cancer
11. FDA Files Application To Convert ONTAK(R) (Denileukin Diftitox) to Full Approval for Use in Cutaneous T-Cell Lymphoma (CTCL)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... , Oct. 1, 2014 ... now available. Interested parties can learn about ... Cardinal Health is supporting the health care ... http://cardinalhealth.com/annualreport . Photo- http://photos.prnewswire.com/prnh/20140930/149504-INFO ... summary financials and the chief executive officer,s ...
(Date:10/1/2014)... 2014  ResMed (NYSE: RMD ), a pioneer ... to design complete sleep apnea solutions specifically for women, is ... of a good night,s sleep. The Better ... feeling tired is just part of living a busy life. ... critical pillar of health, essential to not only living an ...
(Date:10/1/2014)... , Oct. 1, 2014  Varian Medical Systems (NYSE: ... report results for the fourth quarter of fiscal year ... October 22, 2014.  The news release will be followed ... 2:00 p.m. PT.  The news release and a link ... the company website at: www.varian.com/investor .  To access ...
Breaking Medicine Technology:Cardinal Health 2014 Digital Report to Shareholders Now Available 2ResMed Launches Initiative to Help Women Get Better Sleep 2ResMed Launches Initiative to Help Women Get Better Sleep 3Varian Medical Systems Schedules Fourth Quarter FY2014 News Release and Conference Call 2
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, 2014 (HealthDay News) ... -- may face an increased risk of dying in the next ... 3,000 older Americans, researchers found those who were unable to detect ... times as likely to die in the next five years, versus ... -- the inability to distinguish odors -- was a bigger predictor ...
(Date:10/2/2014)... scientists at The University of Nottingham could lead to ... , A drug resulting from the research, published in ... new hope to sufferers of chronic pain conditions such ... are currently available. , The work, led by Dr ... in collaboration with David Bates, Professor of Oncology in ...
(Date:10/1/2014)... that more than 80 per cent of bowel cancers ... found that medicines called ,JAK inhibitors, halted tumour growth ... present in more than 80 per cent of bowel ... in clinical trials, for diseases including rheumatoid arthritis, psoriasis, ... the second-most common cancer in Australia with nearly 17,000 ...
(Date:10/1/2014)... the Engineering and Physical Sciences Research Council (EPSRC) ... vital industrial control systems which run, for example, ... the rail network. , The research will ... malware infiltrating the systems behind our critical national ... Industrial Control Systems (RITICS), based at Imperial College ...
(Date:10/1/2014)... New research suggests the adage that encourages people to ... target when it comes to exercise. When walking, staying ... distance to it appear shorter and help people walk ... compares this technique to walking while looking around the ... quality of exercise. , "People are less interested in ...
Breaking Medicine News(10 mins):Health News:Could a Fading Sense of Smell Point to Earlier Death? 2Health News:Could a Fading Sense of Smell Point to Earlier Death? 3Health News:Medical discovery first step on path to new painkillers 2Health News:Eighty percent of bowel cancers halted with existing medicines 2Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 3
... who cares for patients with cancer at The Children,s Hospital ... Junior Faculty Award in Pediatric Oncology. The American Society of ... award during its annual meeting, occurring June 1-5 in Chicago. ... B. Nachman, a pediatric oncologist and Professor of Pediatrics at ...
... TUESDAY, May 8 (HealthDay News) -- Eating too quickly may ... Researchers from Lithuania compared 234 people with type 2 ... those who gobble down their food were 2.5 times more ... while eating. Study participants with diabetes also were more ...
... Branch at Galveston researchers have discovered that a drug ... also have another important use: treating one of the ... rat and cell-culture experiments, the scientists found that metformin, ... in type 2 diabetes, also substantially reduced the effects ...
... physicians, fees under Medicare which in turn influence ... will pay doctors -- the Centers for Medicare and ... American Medical Association advisory panel. A study led by ... Public Health, found that the Medicare and Medicaid agency ...
... Reporter , MONDAY, May 7 (HealthDay News) -- Those suffering ... their symptoms, but a cure has yet to be found. ... may help patients suffer a little less, but side effects ... preparations impact symptoms of the common cold, there is currently ...
... -- The Medical Publishing Insights and Practices (MPIP) ... editors to characterize the persistent and perceived credibility ... potential approaches to resolve it. This unique round ... Recommendations for Closing the Credibility Gap in Reporting ...
Cached Medicine News:Health News:Diabetes drug could treat leading cause of blindness 2Health News:AMA committee recommendations on doctor fees set by Medicare are followed 9 times out of 10 2Health News:Zinc Pills May Shorten Colds, Analysis Suggests 2Health News:Journals and pharma collaborate on new recommendations 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: