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Data Published in the Journal of the American Society of Nephrology Shows Daily Home Hemodialysis Patients with the NxStage System One Have Significantly Lower Risk of Mortality and Improved 3-Year Survival Versus Patients on Conventional Hemodialys
Date:2/23/2012

emographic characteristics, disease severity measures, transplant waiting list and other severity of disease covariates that could impact mortality. The study demonstrated that in the intention-to-treat analysis:

  • the all-cause mortality hazard ratio was 0.87 (p=0.01) in as-treated patient analyses when compared with patients receiving conventional thrice-weekly in-center dialysis,
  • the cause-specific mortality hazard ratios were 0.92 (p=0.34) for cardiovascular disease; 1.13 (p=0.41) for infection; 0.63 (p=0.03) for cachexia/dialysis withdrawal; 1.06 (p=0.69) for other specified cause; and 0.59 (p<0.01) for unknown cause. For this study, hazard ratios of <1 indicate reduced risk of death, whereas ratios of >1 indicate a greater risk.  Mortality results in the study are associated with a reduced risk of death from cachexia/dialysis withdrawal and unknown causes.

"This study is the largest and most comprehensively matched to date looking at survival in the daily home hemodialysis population, and the positive results are encouraging," said Dr. Allan Collins, MD, FACP, professor of medicine, University of Minnesota, and director, Chronic Disease Research Group. "These results add to the recently published body of large, well conducted studies pointing to significant potential benefits of home and more frequent hemodialysis therapies. Going forward, we must consider the possibility that conventional thrice-weekly treatment may be inadequate for addressing the critical problems of persistent fluid overload, hypertension, and left ventricular hypertrophy, as well as the resultant complications including patient mortality."

"This study uses the best statistical methods available and clearly demonstrates that more frequent home hemodialysis with the NxStage System One can significantly lower mortality and improve survival for thousands of dialysis patients," said Jeffrey H. Burbank, Chief
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SOURCE NxStage Medical, Inc.
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