Navigation Links
Calixa Therapeutics Announces Initiation of Phase 2 Clinical Trial of Its Antibiotic, CXA-101, in Patients with Complicated Urinary Tract Infections
Date:6/30/2009

SAN DIEGO, June 30 /PRNewswire/ -- Calixa Therapeutics Inc. today announced the initiation of a Phase 2 clinical trial of CXA-101 in patients with complicated urinary tract infections. CXA-101 is a new broad-spectrum, parenteral cephalosporin antibiotic with excellent in vitro and in vivo activity against Pseudomonas aeruginosa, including drug resistant isolates. Calixa is investigating CXA-101 as a potential treatment for serious bacterial infections in hospitalized patients.

The multi-center, randomized study is anticipated to enroll approximately 120 patients and will compare the efficacy and safety of CXA-101 with the current standard of therapy. The primary efficacy endpoint for this study is microbiological outcome at the test-of-cure visit between six to nine days after the end of therapy.

"The preclinical and Phase 1 results to date are very promising and indicate that CXA-101 is well tolerated and has broad-spectrum antibacterial coverage, including potent activity against increasingly resistant gram-negative pathogens such as Pseudomonas aeruginosa," said Dr. Ian Friedland, chief medical officer of Calixa. "We are going to present comprehensive preclinical and Phase 1 data at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy in September and other medical conferences. This Phase 2 study will generate important information on the safety and effectiveness of CXA-101 in complicated urinary tract infections, which are usually caused by gram-negative pathogens".

Eckard Weber, president and chief executive officer of Calixa and partner at the venture capital firm Domain Associates, LLC said, "With the continually increasing incidence of serious and life-threatening infections caused by resistant gram-negative bacteria and the paucity of new drugs in the pipeline to counter such
'/>"/>

SOURCE Calixa Therapeutics Inc.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2

Related medicine technology :

1. Calixa Therapeutics Announces Positive Phase 1 Results for CXA-101, a Novel Intravenous Cephalosporin Antibiotic with Excellent Anti-Pseudomonal Activity
2. Vantia Therapeutics Lead Candidate VA106483 Demonstrates Positive Anti-diuretic Effect in Phase IIa Trial in Nocturia
3. Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease
4. Horizon Therapeutics HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain
5. InteKrin Therapeutics to Present at the 2009 American Diabetes Association Annual Meeting
6. Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support
7. Ascenta Therapeutics Announces Multiple Presentations on AT-101 at 2009 ASCO Annual Meeting
8. Oxford BioTherapeutics and GlaxoSmithKline Form Strategic Alliance to Develop Novel Cancer Therapeutic Antibodies
9. FDA Accepts Arno Therapeutics IND for AR-12 a PDK1 Inhibitor That Blocks the PI3K/Akt Pathway
10. Logical Therapeutics Appoints Peter A. Lankau as CEO and Director
11. Arcion Therapeutics Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2009)... 17 Connectyx Technologies Holding Group Inc. ... formed a distribution partnership with United States Medical ... Supplies, Respiratory Supplies and Medications as well as ... System. ,, Terms of the partnership were not ... "This partnership adds to our growing distribution channel ...
(Date:12/17/2009)... -- Instacare Corp. (OTC Bulletin Board: ISCR) a ... drugs and diagnostics and at home testing products ... and provider of e-health technologies and revolutionary cell ... as part of the preparation of its Fiscal ... two new Directors and has rejected, as unneeded, ...
(Date:12/17/2009)... N.C., Dec. 17 Pharmaceutical Institute today ... GeneEd, Inc., a company specializing in life science ... e-courses, help expand Pharmaceutical Institute,s already extensive library ... is a leading provider of specialized training solutions ... subsidiary of Campbell Alliance. Financial terms of ...
Breaking Medicine Technology:Connectyx Announces Distribution Partnership with United States Medical Supply 2Connectyx Announces Distribution Partnership with United States Medical Supply 3Instacare Corp. Board of Directors Sets Growth Plans for 2010 2Pharmaceutical Institute Acquires E-Learning Assets from GeneEd, Inc. 2Pharmaceutical Institute Acquires E-Learning Assets from GeneEd, Inc. 3Thirty one Minnesota Hospitals Win Patient Safety Awards 58783 1Thirty one Minnesota Hospitals Win Patient Safety Awards 58783 2Pillar Capital Announces Acquisition of Medico Labs Assets 58778 1Pillar Capital Announces Acquisition of Medico Labs Assets 58778 2Hamon Tower Features Critical Care Advances Potential for Reduced Costs 5195 1Hamon Tower Features Critical Care Advances Potential for Reduced Costs 5195 2
(Date:12/17/2009)... Today, CDC,s Morbidity and Mortality Weekly Report (MMWR) ... state-level epidemiologists has decreased steadily since 2004, with ... There was also a substantial decrease in core ... capacity for bioterrorism and emergency response. ... health, substance abuse, and oral health, basic epidemiology ...
(Date:12/17/2009)... Hospital is changing the way women manage their bladder ... Good Samaritan Hospital Women,s Center For Bladder & Pelvic ... two common medical problems - lack of bladder control ... rectum (pelvic organ prolapse). Three out of four women ... of three may experience pelvic organ prolapse, but many ...
(Date:12/17/2009)... 17 Today, SEIU ULTCW (United Long ... In-Home Supportive Service (IHSS) providers have overwhelmingly voted ... County that adds multiple layers of protection to ... as well as granting additional contract improvements. ... desire to slash homecare provider wages to as ...
(Date:12/17/2009)... selected Jay and Maureen Neitz, the husband-and-wife team whose ... therapy to treat vision disorders, as the inaugural recipients ... , The award is funded by a $1 million ... graduates Jay Pepose ,75 and Susan K. Feigenbaum ,74, ... in vision science. , The Neitzes, both of whom ...
(Date:12/17/2009)... Hospital Inc. (Rutherfordton, N.C.), a management client since 1983, ... 1992, were recently recognized as top-ranked Community Value Providers ... ... Brentwood, Tenn. (PRWEB) December 17, 2009 ... (Rutherfordton, N.C.), a management client since 1983, and Sturgis ...
Breaking Medicine News(10 mins):Health News:CSTE National Assessment Finds Critical Public Health Disease Surveillance Capacity Lacking 2Health News:Good Samaritan Hospital Launches Women's Center For Bladder & Pelvic Health 2Health News:Good Samaritan Hospital Launches Women's Center For Bladder & Pelvic Health 3Health News:New Alameda County IHSS Contract Sends Clear Message to Elected Leaders That Homecare Program Must Remain a California Priority 2Health News:Vision researchers Jay and Maureen Neitz to receive first Pepose Award from Brandeis 2Health News:QHR Client Hospitals in North Carolina, Michigan Lauded for Providing Community Value 2
... and Lomb Premium Cataract Intraocular Lenses to Be FeaturedSAN ... attend a live surgery and symposium at a San ... procedures conducted by Dr. Jeffrey Whitman broadcast live from ... will implant a Crystalens, the only FDA approved accommodating ...
... However, Most Surveyed MCOs Say They Will Not ... in Stroke Prevention is Greater Convenience, According to ... 2 Decision Resources, one of the world,s ... healthcare issues, finds that, for prevention of stroke, ...
... Health System Commits to Information Connectivity as the ... April 2 Allscripts announced today that Ottawa Regional ... Allscripts solutions to electronically connect its providers across all ... physician offices to the hospital,s home health network, as ...
... BRAINTREE, Mass. and CHICO, Calif., April 2 ... global blood management solutions company, today announced that ... information management company. Altivation provides resource management ... a real-time database which provides a dashboard of ...
... April 2 Xanodyne Pharmaceuticals, Inc. announced today that ... for filing and granted priority review status for its ... of women with menorrhagia, heavy menstrual bleeding (HMB), and ... submitted the New Drug Application (NDA) for XP12B, a ...
... Consumer-Focused Chronic Disease , Prevention and Management ProgramsWASHINGTON, ... for Pharmacy Quality Management, is pleased to announce the ... Consumer Empowerment and Protection Awards. The honorees were announced ... Care Consumer Empowerment and Protection Awards Gala ...
Other Medicine News:Health News:Surgeons to Observe and Discuss Live Eye Surgery Friday Night in San Francisco 2Health News:Surgeons to Observe and Discuss Live Eye Surgery Friday Night in San Francisco 3Health News:For Prevention of Stroke, Surveyed Cardiologists and PCPs Expect to Prescribe Xarelto to Approximately One-Third of Newly-Diagnosed Atrial Fibrillation Patients 2Health News:For Prevention of Stroke, Surveyed Cardiologists and PCPs Expect to Prescribe Xarelto to Approximately One-Third of Newly-Diagnosed Atrial Fibrillation Patients 3Health News:Ottawa Regional Hospital and Healthcare Center Selects Allscripts to Automate and Connect Its Physician Offices, Emergency Department and Home Care Providers 2Health News:Ottawa Regional Hospital and Healthcare Center Selects Allscripts to Automate and Connect Its Physician Offices, Emergency Department and Home Care Providers 3Health News:Ottawa Regional Hospital and Healthcare Center Selects Allscripts to Automate and Connect Its Physician Offices, Emergency Department and Home Care Providers 4Health News:Ottawa Regional Hospital and Healthcare Center Selects Allscripts to Automate and Connect Its Physician Offices, Emergency Department and Home Care Providers 5Health News:Ottawa Regional Hospital and Healthcare Center Selects Allscripts to Automate and Connect Its Physician Offices, Emergency Department and Home Care Providers 6Health News:Haemonetics Bolsters Blood Bank Information Management Portfolio With Acquisition of Altivation Software 2Health News:Xanodyne's New Drug Application for the Treatment of Heavy Menstrual Bleeding (Menorrhagia) Accepted for Filing with a Priority Review Classification 2Health News:Winners of the 2009 URAC Best Practices in Health Care Consumer Empowerment and Protection Awards Announced 2Health News:Winners of the 2009 URAC Best Practices in Health Care Consumer Empowerment and Protection Awards Announced 3
... The CARDIA ASD Occluder has been developed ... defects. Introduced through transseptal venous sheaths the ... for the percutaneous closure of ASD's with ... is incorporated into the twelve arm device ...
Stainless steel plain Steinman Pins available in point types A through F....
Round Bevel-Point Pin Sets available in 2.3mm, 3.1mm, 4.7mm, and 6.3mm sizes....
... , 5mm x 30mm x 175mm, 225mm Half Pin , 5mm x 40mm ... , 5mm, Half Pin , Jet-X Bar 5mm Half Pin ... Half Pin , TI 5mm x 40mm, 1.6 Cannulated ... , TiN 5 x 40, 1.6 Cann , TiN ...
Medicine Products: