Navigation Links
Bad News to Bad Bugs: Northern Antibiotics Develops Novel Polymyxins With Reduced Toxicity
Date:7/1/2008

HELSINKI, July 1 /PRNewswire/ -- The emergence of multidrug-resistant Gram-negative bacteria has necessitated the use of polymyxins as the agents of last resort despite their known nephrotoxicity. Now Northern Antibiotics Ltd, a Finnish biotech company, has developed novel polymyxin derivatives which in early preclinical studies show signs of lower nephrotoxicity.

The derivatives contain three positive charges only, while polymyxin B and colistin have five. They bind to the isolated brush-border membrane of rat kidney at an affinity which is only 1/5-1/7 of that for polymyxin B. In vivo rat studies also show remarkable differences in parameters that are considered to indicate early kidney damage, such as serum urea nitrogen, albuminuria and cylindrouria.

The derivatives fall in to two groups that differ in their mode of action. The lead compound of the first group, NAB 7061, sensitizes enteric bacteria to other antibiotics. For example, it reduces the minimum inhibitory concentration (MIC) of clarithromycin for ESBL-producing strains of Escherichia coli by a factor of 250-750. NAB 739, the lead compound of the second series, acts directly against enteric bacteria. For E. coli (including ESBL-producing strains) the MIC90 is identical to that of polymyxin B. While NAB 739 is already alone highly active against multidrug-resistant strains of Acinetobacter baumannii, it also at very low subinhibitory concentrations sensitizes this bacterium to other antibiotics. A paper entitled "Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents" was published ahead of print on June 30, 2008 (Antimicrob. Agents Chemother., doi:10.1128/AAC.00405-08).

"The efficacy of both lead compounds has been verified using an experimental E. coli peritonitis model in mice, and we are now talking to potential partners to further develop and eventually commercialize these two lines of novel compounds," says Professor Martti V
'/>"/>

SOURCE Northern Antibiotics Ltd
Copyright©2008 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2

Related medicine technology :

1. Northern California Foot and Ankle Center Santa Rosa Enrolling Patients With Chronic Diabetic Foot Ulcers for Matrix Clinical Research Trial
2. ActivBiotics Proposes Development Strategy for Its Novel Rifamycin Antibiotics
3. For Most, Good Oral Care Does More Than Antibiotics to Prevent Dental-Related Heart Problems, Reports the Harvard Heart Letter
4. Nventa Develops Proprietary Vaccine Adjuvant
5. Diplomat Specialty Pharmacy Develops and Launches Best-In-Class Electronic Navigator (eNAV(TM)) Patient Care System
6. DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin
7. Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome
8. Fox Chase Cancer Center and VisEn Medical Announce Program to Advance First Clinical Trials of Novel Fluorescence Molecular Imaging Technologies
9. European Enrollment Begins in Pivotal Phase 3 Trial of Novel Combination Medicine Developed by Cogentus Pharmaceuticals
10. Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma
11. New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2009)... 16 , ... Daniel,Tome,s Supervision and Published* in November 2009, in ... Society "Bone", Reveal new Benefits for,Peptan(TM) in Osteoporosis ... to consumer concerns regarding long-term bone health,Rousselot has ... to demonstrate,that an oral intake of Peptan(TM) may ...
(Date:12/15/2009)... Cellular Dynamics International (CDI) today ... use in testing of new drug candidates by ... are designed to aid drug discovery and improve ... screens, weeding out ineffective and potentially toxic compounds ... time and resources have been invested. ...
(Date:12/15/2009)... ZURICH, Ill., Dec. 15 Fenwal Inc., a ... availability for patient care, reiterated its commitment to provide ... lifesaving blood products, despite a new lawsuit filed yesterday ... Fenwal® Alyx® system, introduced in 2003, is an advanced ... red cells from a single donor in about 30 ...
Breaking Medicine Technology:Published in "Bone" Journal, Scientific Researches Confirm Peptan(TM) Hydrolyzed Collagen Benefits on Bone Health 2Cellular Dynamics Announces Commercial Launch of iCell(TM) Cardiomyocytes for Drug Candidate Toxicity Screening 2Cellular Dynamics Announces Commercial Launch of iCell(TM) Cardiomyocytes for Drug Candidate Toxicity Screening 3Cellular Dynamics Announces Commercial Launch of iCell(TM) Cardiomyocytes for Drug Candidate Toxicity Screening 4Fenwal Responds to New Lawsuit From Haemonetics; Reiterates Commitment to Blood Centers 2Fenwal Responds to New Lawsuit From Haemonetics; Reiterates Commitment to Blood Centers 3Bupa Launches its 2009 International Charity Challenge to Help a Rural Community in Ecuador 56934 1Bupa Launches its 2009 International Charity Challenge to Help a Rural Community in Ecuador 56934 2John C Moran Named CEO at Core Essence Orthopaedics 56930 1John C Moran Named CEO at Core Essence Orthopaedics 56930 2Hard To Treat Diseases 28HTDS 29 MEVAC A Completes Tender For Bangladesh 56926 1Hard To Treat Diseases 28HTDS 29 MEVAC A Completes Tender For Bangladesh 56926 2Hard To Treat Diseases 28HTDS 29 MEVAC A Completes Tender For Bangladesh 56926 3
... Interleukin Genetics, Inc. (NYSE Amex: ... research findings from a large clinical study on the ... International Symposium on Osteoporosis: Translating Research into Clinical Practice, ... Hotel in Washington, D.C. The Company,s research poster, ...
... SALZBURG, Austria, March 31 We may introduce the first,"A"- Implant novelty ... - biological, - two-part system, - ... - made of most reliable Zirconium oxide, - Manufactured ... experience, , After 4 years of research and ...
Other Medicine Technology:Interleukin Genetics Presents Research Linking Vertebral Fractures to Gene Variations in Asian Women With Osteoporosis 2Interleukin Genetics Presents Research Linking Vertebral Fractures to Gene Variations in Asian Women With Osteoporosis 3
(Date:12/16/2009)... CAMBRIDGE, Mass., Dec. 16 Sermo ( ... physicians, today announced the results of a new ... Media Conversations ." The report examines physician ... provides a complete analysis of a variety of ... the brands they prefer, and candid/verbatim comments on ...
(Date:12/16/2009)... While many of the,pharma companies ... models,for new and inmarket drugs, MarketsandMarkets on ... to various players. These pharma,forecasting solutions are ... well as phase,III. These have a substantial ... market entry strategy, manufacturing planning, sales force,promotion, ...
(Date:12/16/2009)... finds 6- to 11-month interval lessens complication risks , , TUESDAY, ... of joy has had such a profound impact on your ... a breath. A new study suggests that you might ... again, and that more than 11 months could be even ... between pregnancies was less than six months, the chances of ...
(Date:12/16/2009)... 21-count one week trial bottle sample with purchase of 90-count bottle. ... ... -- ImmuneResponse247.com announces a special free offer for ... 247™ 6 Mushroom Formula , with the purchase of a 90-count ... Formula is packaged in FDA approved facilities and blends the 6 ...
(Date:12/16/2009)... cost of hearing aids has been brought into reach for many ... subscription based hearing plan. , ... (PRWEB) December 16, ... reach for many Houstonians with the announcement by Hearing Haven, LLC ... by hearing better on the job, and want to improve communications ...
Breaking Medicine News(10 mins):Health News:Sermo Vitals Report(TM) Quantifies One Year of Physician Conversation About Diabetes 2Health News:Sermo Vitals Report(TM) Quantifies One Year of Physician Conversation About Diabetes 3Health News:MarketsandMarket's Integrated Patient-based Forecasting Solution for Pharmaceutical Industry, Mainly for Pipeline Products 2Health News:MarketsandMarket's Integrated Patient-based Forecasting Solution for Pharmaceutical Industry, Mainly for Pipeline Products 3Health News:For Babies' Sake, Pregnancy Spacing Matters 2Health News:For Babies' Sake, Pregnancy Spacing Matters 3Health News:Free Sample of Proven Health Mushroom Supplement Offered By ImmuneResponse247.com 2Health News:Free Sample of Proven Health Mushroom Supplement Offered By ImmuneResponse247.com 3Health News:Free Sample of Proven Health Mushroom Supplement Offered By ImmuneResponse247.com 4Health News:Monthly Subscription Hearing Aid Plan Announced for Houston 2
... BOSTON, Nov. 27 J. Robert Scott, ... Young, a global leader in,professional services; and ... collaboration with professors from Harvard Business School,have ... Entrepreneurship Report in,Life Sciences, available at ...
... Going through airport security,can be such a hassle. ... off, taken out, scanned, examined, handled and repacked. ... may reshape,not only airport screening procedures but also ... Department of Energy,s Argonne National,Laboratory, along with collaborators ...
... HILL, N.C., Nov. 27 A story published ... spam" -- the habit of,co-workers indiscriminately hitting the ... research by benchmarking leader Best Practices, LLC,uncovered a ... -- the,tendency of organizations to send redundant announcements ...
... 27 The Aesthetic Extender,Symposium announced its inaugural event ... will be held in Miami Beach,Florida on October 23 ... first,and only event of its kind. Unlike other events ... mission statement a goal of adhering to,the policies and ...
... emission tomography (PET) is a useful diagnostic tool that ... cancer and improved treatment for patients, concludes an extensive ... Cancer Institute. , The review conducted by ... Ontarios Program in Evidence-Based Care led by a Sunnybrook ...
... who may need bone-strengthening therapies, experts say , , TUESDAY, ... a model to help doctors predict which postmenopausal women ... five-year period. , The algorithm includes 11 different factors ... applies to postmenopausal women of different ethnic backgrounds. ...
Other Medicine News:Health News:2007 Life Sciences Compensation Findings Disclosed www.compstudy.com 2Health News:2007 Life Sciences Compensation Findings Disclosed www.compstudy.com 3Health News:2007 Life Sciences Compensation Findings Disclosed www.compstudy.com 4Health News:New T-ray Source Could Improve Airport Security, Cancer Detection 2Health News:New T-ray Source Could Improve Airport Security, Cancer Detection 3Health News:New T-ray Source Could Improve Airport Security, Cancer Detection 4Health News:Using Efficient Communication to Boost Pharma Sales Force Productivity 2Health News:PET imaging significantly enhances standard imaging in lung cancer staging 2Health News:Criteria Predict Women's 5-Year Risk for Fracture 2
Sleek, all-metal head with large-diameter viewing window. 3X magnification....
Provides 30% more magnification and twice the field of view. Adjustable focus....
... and FSE are a new series of ... is outside of the cryochamber, which allows ... faster temperature adjustment. Simple, multi-lingual touch-screen display ... on the main touch-screen display. Angle of ...
... The Novus Spectra photocoagulator delivers ... in diode-pumped solid-state (DPSS) technology. Diode ... power from the compact Novus Spectra ... ensures stable beam output and system ...
Medicine Products: