Navigation Links
arGEN-X Announces Preclinical Development of ARGX-112 for Dermatology
Date:3/25/2013

BREDA, The Netherlands and GHENT, Belgium, March 25, 2013 /PRNewswire/ --

ARGX-112 targets IL22R1, a novel target involved in chronic skin inflammation

arGEN-X, a clinical stage biopharmaceutical company specialized in the discovery and development of highly differentiated human monoclonal antibody therapeutics, announces that it has progressed ARGX-112, its fourth therapeutic candidate, into formal preclinical development.

ARGX-112 is a novel, fully human antibody neutralizing both IL20 and IL22 signaling through blockade of their common receptor, IL22R, with low picomolar potency. IL20 and IL22 are involved in proliferation and differentiation of keratinocytes (skin cells) and when over-expressed, are implicated in autoimmune diseases of the skin, including atopic dermatitis, psoriasis and pustular psoriasis. ARGX-112 has been shown to be highly effective in several preclinical models of chronic skin inflammation.

ARGX-112 was selected from a panel of more than 68 antagonistic anti-IL22R antibodies, several with specificity for previously unknown epitopes on the receptor, which were generated from arGEN-X' highly productive and efficient SIMPLE Antibody™ platform. ARGX-112 has demonstrated ultra-high neutralization potency, and as a result of further optimization through application of arGEN-X' NHance™ technology, has favorable in vivo pharmacokinetics and distribution to the skin. These important characteristics make it a very attractive development candidate for the treatment of dermatology indications. ARGX-112 is one of a pipeline of highly differentiated therapeutic antibody programs under development at arGEN-X for the treatment of autoimmune disorders, inflammation and cancer. The initiation of formal preclinical development for ARGX-112 marks the fourth program to progress to this stage in only 40 months since the start of the Company's operations.

arGEN-X' most advanced program is ARGX-110, a fully human antibody with unprecedented neutralization potency for CD70, a compelling immunomodulatory target for the treatment of cancer and autoimmunity. arGEN-X initiated a Phase Ib study with ARGX-110 in January 2013.

Commenting further on the Company's progress, Tim Van Hauwermeiren, CEO of arGEN-X, said: "We are pleased to expand our product development pipeline with ARGX-112, another high-quality human therapeutic candidate. The speed and efficiency with which we have built our pipeline is testament to the unique power of our SIMPLE Antibody™ platform. We believe that ARGX-112 is a very attractive candidate for treatment of a broad range of chronic inflammatory skin conditions. The results we have generated in preclinical models of skin disease, along with the inherent characteristics of ARGX-112 itself, give us great confidence in the development potential of this candidate. We are now exploring partnerships with dermatology specialists committed to bringing novel therapies making a clear difference to patients with atopic dermatitis and psoriasis."

About arGEN-X

arGEN-X is a clinical stage human therapeutic antibody company that is rapidly developing a product pipeline using its unique suite of antibody technologies. arGEN-X is creating first and best in class antibody therapeutics with highly differentiated target product profiles. Its therapeutic antibody programs, focused on cancer and autoimmune indications, are designed to deliver tangible benefits to patients with these significant diseases.

arGEN-X' SIMPLE Antibody™ platform generates an unprecedented diversity of high quality human antibodies, enabling optimal product choice. SIMPLE Antibodies™ can address and modulate any disease target, including complex receptors and highly conserved targets often intractable with other antibody technologies. SIMPLE Antibody™ generated leads can be further differentiated through enhancement of cell killing properties (POTELLIGENT®  technology) and optimization of circulation time and distribution in the body (NHance™ technology).  

The power and productivity of the SIMPLE Antibody™ platform has already allowed arGEN-X to successfully deliver against challenging targets for its partners Shire and Lilly at record speed and efficiency.

For further information, please contact:

Citigate Dewe Rogerson
David Dible
Mark Swallow
Nina Enegren
T: +44-207-282-2949/2948/1050
E: david.dible@citigatedr.co.uk

arGEN-X
Tim Van Hauwermeiren, MSc, eMBA
Chief Executive Officer
T: +31-6-122-85-257
E: tim.vh@arGEN-X.com

Debbie Allen , Ph.D.
Senior Director, Business Development
T: +44-7974-979479
E: dallen@arGEN-X.com


'/>"/>
SOURCE arGEN-X
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. arGEN-X Appoints Dr. David L. Lacey to its Supervisory Board
2. Precision Optics Corporation Announces $1 Million Order for Microprecision™ Based Endoscopes
3. Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012
4. JDRF Announces Research Collaboration with Dexcom, Inc. to Develop "Smart Transmitter" Technology to Accelerate Artificial Pancreas Studies
5. Misonix Announces New Distribution Agreement For Panama
6. University of Maryland BioPark Announces MedImmunes Dr. Bahija Jallal as Newest Member of Board of Directors for UM Health Sciences Research Park
7. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
8. Boston Scientific Announces CE Mark and European Launch of Emerge™ PTCA Dilatation Catheter
9. Soligenix Announces Further Progress with ThermoVax™ for Long-Term Vaccine ThermoStability
10. Masimo Announces New Low-Profile Infant and Neonatal Pulse Oximetry Sensors
11. Anthera Announces the Completion of Patient Dosing in Phase 2b PEARL-SC Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing ... of targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... Fairfax, VA (PRWEB) , ... October 13, 2017 ... ... provider of DevOps and Agile Software Development, has been awarded a contract by ... (EATS) Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... WAUSAU, Wis. (PRWEB) , ... October 12, 2017 ... ... formulated standard products to meet the demand of today’s consumer and regulatory authorities ... team of probiotic experts and tested to meet the highest standard. , ...
Breaking Medicine News(10 mins):