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arGEN-X Announces Non-Exclusive License With BioWa for POTELLIGENT® Technology
Date:7/26/2011

strategy of creating highly differentiated, competitive antibody products."  

Dr. Yasunori Yamaguchi, President and CEO of BioWa, commented further: "We are pleased to have this arrangement with an innovative company such as arGEN-X.  The SIMPLE Antibody™ platform and POTELLIGENT® Technology are very complementary and promise to enable important increases in therapeutic antibody potency."

About arGEN-X - www.arGEN-X.com

arGEN-X aspires to be a transforming force in the therapeutic monoclonal antibody arena. Its SIMPLE Antibody™ platform is unmatched in its ability to blanket human disease targets with functional antibodies, including targets that cannot be accessed by conventional discovery platforms. SIMPLE Antibodies™ have human sequences and structures, femtomolar affinities and potencies as well as excellent manufacturability. The characteristics of SIMPLE Antibodies™ provide arGEN-X and its partners with unprecedented choice in developing differentiated therapeutic mAb products.

arGEN-X™ and SIMPLE Antibody™ are deposited trademarks of arGEN-X BV.

SIMPLE stands for Superior Immunodiversity with Minimal Protein Lead Engineering

About POTELLIGENT® Technology

POTELLIGENT® Technology improves potency and efficacy of antibody therapeutics by enhancing ADCC, one of the major mechanisms of action for antibody therapeutics.  POTELLIGENT® Technology involves the reduction of the amount of fucose in the carbohydrate structure of an antibody using a proprietary fucosyl transferase-knockout CHO cell line as a production cell.  Research shows that POTELLIGENT® Technology dramatically enhances ADCC activity of an antibody in vitro, and significantly increases potency and efficacy of the antibody in vivo. A number of POTELLIGENT®
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SOURCE BioWa, Inc.
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