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Analysis Compares Cost-Effectiveness of Premixed Insulin Analogs to Long-Acting Insulin Analogs in the Long-Term Treatment of Type 2 Diabetes in the U.S.
Date:6/24/2011

run over a time horizon of 35 years to capture all relevant long-term complications and associated costs and assess their impact on life expectancy and quality-adjusted life expectancy. Future cost and clinical outcomes were discounted at 3 percent annually.

Sensitivity analyses were performed to investigate the effect of time horizon, discounting, minor hypoglycemia rates, diabetes complication costs, insulin costs and method of quality-adjusted life expectancy estimation on outcomes.

Study limitations included variability in the quality of the reported data on hypoglycemia rates from the studies used for the meta-analysis. Additionally, the meta-analysis represented data from short-term clinical trials, which was extrapolated to make long-term projections.

"We know that 28 percent of people with type 2 diabetes use insulin to manage their diabetes, and once insulin treatment begins, it could be a life-long part of their disease management," said Dana Hardin, MD, a clinical research physician at Lilly. "These study findings are encouraging because, while not all patients are candidates for premixed insulin, those who are may have another viable and cost-effective treatment option."

Diabetes affects more than 25 million people in the U.S.(1) and is the fifth leading cause of death by disease. In 2007, the most recent year for which data is available, costs for diabetes were approximately $174 billion dollars.(2)

Indication

Who should use insulin lispro premixed insulin analogs?

Insulin lispro premixed insulin analogs are used to treat people with diabetes for the control of high blood sugar.

Important Safety Information for insulin lispro, insulin lispro mix 75/25, and insulin lispro mix 50/50

Who should not take Insulin lispro, insulin lispro mix 75/25, or insulin lispro mix50/50?  

  • Do not tak
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SOURCE Eli Lilly and Company
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