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aTyr Pharma Awarded Two Patents from USPTO to Support Development of New Therapeutics Based on Physiocrine Biology
Date:8/14/2013

SAN DIEGO, Aug. 14, 2013 /PRNewswire/ -- aTyr Pharma, an innovative medical therapeutics enterprise, announced today that the United States Patent and Trademark Office (USPTO) has granted two patents that protect therapeutic and pharmaceutical compositions for two novel Physiocrines. Physiocrines are naturally occurring human proteins that possess novel in vivo biological activity as extracellular signaling molecules in known pathways relevant to developing protein therapeutics for a range of diseases. 

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"Physiocrines are a new class and a significant source of novel proteins to treat many different types of diseases.  We have dedicated ourselves to meticulously exploring and validating the biology associated with Physiocrines and developing an emerging pipeline of therapeutics," said John Mendlein, Ph.D., CEO and executive chairman of aTyr Pharma.  "Building this patent estate also reflects our business model and leverages our research efforts, including those accomplished at Pangu BioPharma, our subsidiary in Hong Kong that is a collaboration with the Hong Kong University of Science and Technology and has received research grants from the Hong Kong Innovation and Technology Commission."

Dr. Mendlein continued, "From our explorations, we have established a dominant intellectual property estate to protect the core therapeutics as well as associated diagnostics so that we can develop meaningful medicines that can benefit patients who face grave diseases."

Physiocrines are produced from ancient genes, aminoacyl tRNA synthetases, an intercellular gene family in protein synthesis. Overlooked by genomic discovery efforts, Physiocrines are naturally occurring proteins that modulate extracellular signaling pathwa
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