Navigation Links
aTyr Pharma Announces Publication of a Rare Muscle Disease Associated with Regulation of a Potential Physiocrine
Date:7/14/2014

SAN DIEGO, July 14, 2014 /PRNewswire/ -- aTyr Pharma, an innovative rare disease therapeutics enterprise announced today, the scientific publication of a splice variant of a tRNA synthetase in association with a rare muscle disease.  This article, published in the Journal of Biological Chemistry, demonstrated novel findings relative to Physiocrine proteins, that include extracellular functions derived from the tRNA synthetase gene family.  These data further highlight the potential role of Physiocrine splice variants in muscle physiology.  The data is consistent with the discovered splice variant being a target of auto-antibodies in a rare muscle disease.

"This is an important milestone in our journey towards understanding the role that physiocrines, like those described in this paper, play in regulating tissue homeostasis in normal tissues and in diseased states," said John Mendlein, Ph.D., CEO and executive chairman of aTyr Pharma. 

About Physiocrines
Among their various homeostatic functions, some Physiocrines act as extracellular signaling molecules to orchestrate immuno-homeostasis in response to stress and other physiological changes. Physiocrines comprise naturally occurring proteins derived from tRNA synthetases that play fundamental roles in the function of human physiology and restoring pathophysiological states to a healthier state. aTyr is currently focused on Physiocrines that act as endogenous modulators of our immune and regenerative systems. Physiocrines offer the opportunity for modulating biological pathways through newly discovered naturally occurring mechanisms, many of which may provide multiple therapeutic advantages, including improved efficacy and reduced side effect profiles compared to many existing therapeutics.

About aTyr Pharma
aTyr Pharma is developing  a pipeline of therapeutic products based on Physiocrine biology. To
'/>"/>

SOURCE aTyr Pharma
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Study Finds Utilizing Integrated Medical and Pharmacy Data Improves Ability to Forecast Use of High-cost Specialty Treatments
2. Report Presents a Framework for Successful New Oncology Product Launches in the Pharmaceutical Sector
3. WuXi PharmaTech Files 2011 Annual Report on Form 20-F
4. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
5. Pharmaceutical Industry Service Company Awarded The UKs Most Prestigious Business Accolade in Recognition of Outstanding Achievement in International Trade
6. Academy of Managed Care Pharmacy (AMCP) Installs 2012-2013 Board of Directors
7. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
8. Simcere Pharmaceutical Group to Announce First Quarter 2012 Financial Results on Wednesday, May 9, 2012
9. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
10. Thomson Reuters Launches New Mobile Oncology Decision Support Solution for R&D Pharmaceutical Leaders
11. Amgen to Acquire Mustafa Nevzat, a Leading Privately Held Turkish Pharmaceutical Company
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... , Dec. 23, 2014  Medical Science Liaisons ... the key link between the medical device industry and ... more in the coming years as the device industry ... According to research by benchmarking firm, Best Practices, ... gain an important edge is by harnessing new technology ...
(Date:12/22/2014)... Apnea Sciences ( www.apneasciences.com ) announced it ... Aliso Viejo , California.  Jimmy Fallon , ... and worldwide expansion, a new facility with expanded infrastructure ... snore cure have exceeded our expectations and thus required ... in 23 countries and will be increasing to 39 ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... addition of the "Investment Analysis of the ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... the US medical device sector identifies the key ... venture capital investments, and mergers and acquisitions. ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2Investment Analysis of the US Medical Device Sector 2
... PHILADELPHIA , July 14 ERT (Nasdaq: ERES ), ... Keith Schneck , the Company,s Executive Vice President and CFO, are ... Healthcare Conference at 3:00 PM ET on August 5, 2010 in New York ... Interested parties may ...
... 14 Viveve, Inc., a women,s sexual health ... to treat vaginal laxity, recently received notification that its ... for the International Continence Society (ICS), International Urogynocological Association ... and the International Society of Sexual Medicine (ISSM). The ...
Cached Medicine Technology:ERT to Present at The BMO Capital Markets 10th Annual Focus on Healthcare Conference on August 5, 2010 2Viveve-Sponsored Research Accepted for Presentation at Two Prestigious International Conferences 2Viveve-Sponsored Research Accepted for Presentation at Two Prestigious International Conferences 3
(Date:12/25/2014)... The report “TS-1 (Colorectal Cancer) – Forecast ... treatment landscape, unmet needs, current pipeline and commercial opportunities ... drug which is typically used for treating colorectal cancer. ... treating gastric cancer and pancreatic cancer. TS-1 is composed ... first approved in 1999 in Japan for the treatment ...
(Date:12/25/2014)... 25, 2014 The short film “Color of ... in honor of a true 9/11 hero, Welles Remy Crowther. ... including the 24 hours of Nuremberg International Short Film Festival ... , Actress, screenwriter and director Luciana Lagana plays ... together with her husband, Gregory Graham - Graham ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Recently, LunaDress.co.uk has updated ... dresses and related accessories. Now, all of the models at LunaDress.co.uk ... moment a groom lifts the wedding veil can turn out to ... stunning charm. A wedding veil can always bring surprise to a ... suggestions on how to choose veils for a big day ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 ... "fountain of youth" drug that can delay the effects of ... study suggests. Seniors received a significant boost to their ... signaling pathway linked to aging and immune function, researchers with ... medication, a version of the drug rapamycin, improved the seniors, ...
(Date:12/25/2014)... 2014 Residents at Abernethy ... showed their generous spirit by providing holiday gifts ... Parenting Network- Grandparents Raising Grandchildren program. , Following ... the largest Christmas tree on the campus of ... residents of the Abernethy Village Association (AVA). Each ...
Breaking Medicine News(10 mins):Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Retirement Community Residents Make Impact During Holiday Season 2
... donor kidneys for transplantation. One solution is to increase ... ,A recent paper in the November issue of the ... kidneys, strategies that have been developed to increase the ... of the adoption of these strategies at a single ...
... atrophy, gynecomastia, and loss of sexual interest have often ... been reported in men who are long-term alcohol users,// ... of ethanol might cause gonadal disorders, including structural testicular ... of T, which might be involved in the hypogonadism ...
... diverse range of insults, such as surgery, infection and ... cell types of the immune system, creating a number ... although essential for fighting infection, may damage the host. ... and lipid mediators being the key mediators. ...
... Theodor Eich and his colleagues from University of Cologne, ... Hodgkin’s Lymphoma patients undergoing chemotherapy does not increase the ... side effects of radiation therapy. The results of the ... and Oncology. The researchers have reduced the radiation dosage ...
... both of great public health importance in tropical countries. ... malaria episodes are associated with transient increases of HIV-1 ... malaria episodes might accelerate HIV-1 disease progression and facilitate ... deleterious effects of HIV-1 infection on malaria. In pregnant ...
... Itomura and his colleagues from Toyama University, Japan have ... aggression of school children’s behavior. //Researchers have found that ... fish oil, is an important component of cell membranes ... behavior problems in boys who have lower concentrations of ...
Cached Medicine News:Health News:Strategies To Boost Living Donor Kidney Transplants 2Health News:Detrimental Effect Of Chronic Alcoholism On Male Fertility 2Health News:The ideal composition of intravenous lipid emulsion 2Health News:Malaria infection can accelerate HIV infection and disease progression 2
The PC2200i contains two shelves and will hold two PF96i agitators. It can store 192 random bags (64 apheresis bags)....
This model of bench top refrigerated incubator has been designed to suit the TPS-16 platelet shaker....
An enzyme-linked immuno-sorbent assay for the detection and quantitation of anti-tissue Transglutaminase in serum of patients with Celiac Disease and Dermatitis Herpetiformis....
... immunosorbent assay method for the semi-quantitative determination ... human serum. The results of the anti-Gliadin ... aid in the diagnosis of diseases associated ... Coeliac Disease. Levels of these autoantibodies are ...
Medicine Products: