Navigation Links
Zimmer and ISTO Technologies Announce Phase III Clinical Study to Evaluate the Effectiveness of Engineered Juvenile Cartilage to Repair Damaged Knees
Date:2/7/2012

SAN FRANCISCO, Feb. 7, 2012 /PRNewswire/ -- Zimmer Holdings, Inc. (NYSE and SIX: ZMH), a global leader in musculoskeletal health, and ISTO Technologies, Inc., an orthobiologics company focused on developing breakthrough products to regenerate and restore function to damaged cartilage and bone, today announced a Phase III clinical study to evaluate DeNovo® ET Engineered Tissue Graft, an engineered cartilage implant intended to repair cartilage defects in the knee.  DeNovo ET Graft is being developed under a collaborative relationship between ISTO and Zimmer. 

"The DeNovo ET Graft program represents a natural extension to our early intervention and joint preservation portfolio," said Cheryl R. Blanchard, Ph.D., Senior Vice President and Chief Scientific Officer at Zimmer.  "This Phase III study will generate meaningful data on the potential of this novel biological solution for treatment of cartilage lesions earlier in the continuum of care."

The Phase III study will comprise a randomized, controlled clinical trial involving 225 patients at up to 25 centers in the United States. The program is designed to demonstrate superiority of DeNovo ET Graft over the current standard of care (microfracture) for articular cartilage defects.  

In preclinical studies, cartilage cells derived from juvenile tissue demonstrated a significantly greater capacity for regenerating cartilage compared to cells derived from adult cartilage.  Recognizing and harnessing the significant regenerative capacity differences between adult and juvenile cells is an underlying principle of ISTO's platform for cartilage repair.  In addition, through a proprietary scalable manufacturing process, ISTO has developed a platform technology for cartilage regeneration using juvenile cartilage cells.

"It is gratifying for our team to see our breakthrough cartilage repair technology advancing from research into a
'/>"/>

SOURCE Zimmer Holdings, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Zimmer Announces Acquisition of Synvasive Technology, Inc.
2. Zimmer Holdings Announces Live Audio Webcast and Conference Call of Fourth Quarter and Year End 2011 Results
3. Zimmer Initiates Quarterly Dividend and Announces New Share Repurchase Program
4. Zimmer Introduces New CLS® Brevius™ Hip Stem with Kinectiv® Technology in the United States
5. Zimmer to Establish Asia-Pacific Research and Development Center
6. Zimmer Announces Acquisition of XtraFix® External Fixation System
7. Zimmer Holdings, Inc. Agrees to Sell $550 Million of Senior Notes
8. Zimmer Holdings, Inc. Announces Offering of Senior Notes
9. Zimmer Introduces inViZia™ Anterior Cervical Plate System at NASS Annual Meeting
10. Zimmer Holdings to Present at 2011 Credit Suisse Annual Health Care Conference
11. Zimmer Holdings, Inc. Reports Third Quarter 2011 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... PARIS , May 6, 2015 ... the development and manufacture of filtration products, mainly for ... ZenPure designs custom filters manufactured in a state-of-the-art plant ... are marketed and sold across the globe and will ... Plastics business. This acquisition is fully in ...
(Date:5/6/2015)... , May 6, 2015  Membership in Medicare Supplement ... a Healthcare Business Strategy report released by Mark ... as Medigap or Med Supp plans, covered approximately ... a 5.2% increase from 2013. Between 2013 and ... 551,135 covered lives.  Though UnitedHealth was the segment ...
(Date:5/6/2015)... Research and Markets ( http://www.researchandmarkets.com/research/7qn2gf/global_insulin ... "Global Insulin Patch Market Opportunity Analysis" report ... like ultrasound and iontophoresis are being used for ... the type of technique, their prices may vary ... patients. In long-term, it would be considered as ...
Breaking Medicine Technology:Saint-Gobain Acquires ZenPure, a Specialist in Filtration Products 2Continued Growth in Med Supp Market for 2014 according to Mark Farrah Associates 2Global Insulin Patch Market Opportunity Analysis 2015 2
... First Effective Drug for Rare Genetic Disorder in,Children--, ... drug to achieve normal levels of blood sugar ... levels. If this approach,succeeds in humans, it could ... a rare but potentially devastating genetic,disease in which ...
... Pathwork Diagnostics, Gene Expression Test Is the First to Receive FDA, ... ... U.S. Cancer Cases Annually, SUNNYVALE, Calif., July 31 Pathwork ... U.S. Food and Drug Administration (FDA) has cleared its Pathwork(R),Tissue of ...
Cached Medicine Technology:Treatment Corrects Severe Insulin Imbalance in Animal Studies 2Treatment Corrects Severe Insulin Imbalance in Animal Studies 3FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors 2FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors 3FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors 4
(Date:5/6/2015)... May 06, 2015 TMG Health, the ... the Medicare Advantage, Medicare Part D and Managed Medicaid ... and Resilience Team category at the BCI North America ... to recognize the outstanding contribution of business continuity professionals ... America Region, including the USA and Canada. The North ...
(Date:5/6/2015)... was featured on NewsWatch as part of its monthly AppWatch, which ... market for iOS, Android, and Windows. Joe Toohey, the host of ... viewers how this application walks users through recipes. , Remember ... had to know how to read a map? And then GPS ... if people could “GPS” their way through a cooking recipe? Would ...
(Date:5/6/2015)... (PRWEB) May 06, 2015 Marketing ... #1 ranked international water, sanitation and hygiene nonprofit by ... communities across the world and it brings our agency ... CEO of Marketing Maven. “The ongoing relationship between ... available for people to learn about and support the ...
(Date:5/6/2015)... Anitha Nallari, MD has joined ... Inc. in Columbus, OH. Dr. Nallari will see patients ... in breast cancer, lung cancer, GI and gallbladder cancer, head ... benign hematology. , Dr. Anitha Nallari is Board ... American Board of Internal Medicine. She completed her medical education ...
(Date:5/6/2015)... 06, 2015 Vancouver Chiropractic Clinic, ... their new blog containing the Canadian Physical Activity ... Canadian Society for Exercise Physiology (CSEP). Since the ... health and fitness research and personal training in ... are highly beneficial and a rich resource for ...
Breaking Medicine News(10 mins):Health News:TMG Health Recognized by the Business Continuity Institute 2Health News:TMG Health Recognized by the Business Continuity Institute 3Health News:An Application to Guide Users through Recipes Was Featured on NewsWatch Television 2Health News:Marketing Maven Expands Partnership with the #1 Ranked International Water, Sanitation and Hygiene Nonprofit 2Health News:Marketing Maven Expands Partnership with the #1 Ranked International Water, Sanitation and Hygiene Nonprofit 3Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 2Health News:New Oncologist to Join Hematology Oncology Consultants, Inc. 3Health News:Vancouver Chiropractor Shares Canadian Physical Activity and Sedentary Behavior Guidelines by CSEP in New Blog 2
... ... news to the cold north of an online business opportunity that has people earning ... and feature the Company’s Mission of harnessing the power of the Internet to improve ... ...
... for insomnia significantly improved sleep for patients with chronic ... to which pain interfered with their daily functioning, according ... researchers. The study, published online by the journal ... can help patients who already are taking medications for ...
... , , RUTHERFORD, N.J. , ... entered into an agreement with MWI Veterinary Supply, Inc. to distribute ... Idaho , sells more than 30,000 products sourced from over 500 ... very excited to be deepening our relationship with one of the ...
... MARINA DEL REY, Calif. , Feb. 11 ... Family, and CEO Dr. Richard Merkin have been ... service and dedication as a leading health care provider. , ... Commerce of the San Fernando Valley and Region, honored Lakeside ...
... , NEW YORK , ... for Justice and Democracy: , A group of medical malpractice survivors, ... as a result of medical negligence, today sent letters to President ... reforms" out of the health insurance reform bill.  They said that ...
... fly could provide big answers to questions about human eating ... according to a study from a team of Texas A&M ... Professor of Biology, along with colleagues Abhishek Chatterjee, Shintaro Tanoue ... ,s proboscis (tongue), which triggers the minute fruit fly,s desire ...
Cached Medicine News:Health News:ShopToEarth Brings Eco-Friendly Green Business Plan to New Jersey and Michigan: Free Overview and Training Seminars 2Health News:ShopToEarth Brings Eco-Friendly Green Business Plan to New Jersey and Michigan: Free Overview and Training Seminars 3Health News:Behavioral therapy improves sleep and lives of patients with pain 2Health News:Summit VetPharm Enters Agreement With MWI Veterinary Supply to Distribute Vectra(R) Products 2Health News:Summit VetPharm Enters Agreement With MWI Veterinary Supply to Distribute Vectra(R) Products 3Health News:Lakeside Medical Organization, Dr. Richard Merkin, CEO, Honored by United Chambers of Commerce 2Health News:Medical Malpractice Survivors Urge President Obama to Keep 'Tort Reform' out of Health Insurance Bill 2Health News:Tiny fruit fly could offer big clues in fight against obesity, researcher says 2