Navigation Links
Zevalin(R) Combined With High-Dose Chemotherapy and Autologous Stem-Cell Transplantation (ASCT) Produces High Overall Survival and Progression-Free Survival Rates in Patients With Relapsed Non-Hodgkin's Lymphoma
Date:1/17/2008

Results underscore promise of radioimmunotherapy in ASCT and warrant

randomized trial

SEATTLE, Jan. 17 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq and MTAX: CTIC) announced today that results of a phase II clinical study, published in the Journal of Clinical Oncology demonstrate that the addition of radioimmunotherapy (RIT) to high-dose chemotherapy (HDC) followed by autologous stem-cell transplantation (ASCT) produced a high rate (70 percent) of progression-free survival at two years without a significant increase in the toxicity of the HDC regimen underscoring the potential role for RIT in ASCT. Total-body irradiation (TBI) has previously been shown to significantly increase progression-free survival when added to HDC followed by ASCT as compared to HDC alone. However, TBI has long term complications and not all patients are eligible to receive TBI as part of their preparative regimen. Radioimmunotherapy with Zevalin(R) (Ibritumomab Tiuxetan), approved for follicular, low grade NHL which relapsed following 1st line rituximab based therapy, allows high doses of lymphoma-targeted radiation with lower doses to normal tissues.

The study, conducted at the City of Hope Comprehensive Cancer Center, used a single dose of Zevalin in patients undergoing ASCT following HDC with the BEAM regimen (carmustine, cytarabine, etoposide, and melphalan). Thirty-seven of the 41 patients had failed prior rituximab therapy. Seven of the ten patients transplanted in partial remission (70 percent) converted to complete remissions following the Zevalin-based regimen. The addition of Zevalin to the BEAM regimen did not appear to add to the toxicity of HDC; the day 100 mortality rate was zero (0) percent. Importantly the 2-year overall and progression-free survival estimates were approximately 89 percent and 70 percent, respectively.

"The promise of utilizing targeted radioimmunotherapy together with high-dose ch
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Roches Investigational Polymerase Inhibitor, Combined with PEGASYS(R) and COPEGUS(TM), Shows Potent Antiviral Activity in Treatment of Chronic Hepatitis C at Four Weeks
2. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
3. Genasense(R) Can be Administered by Brief High-Dose IV Infusion
4. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
5. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
6. Advanced Life Sciences to Present Data on Selected Cethromycin Therapeutic Studies at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
7. Tablet PC Technology Helps Doctors and Patients Focus on Chemotherapy Side Effects, According to Thomson Healthcare Study
8. Promising Data from Paratek Pharmaceuticals MAR Inhibitor Program Presented in Late Breaker Session at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
9. Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
10. Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
11. ASCO and ASH Release Updated Guideline on the Use of Chemotherapy-Related Anemia Treatments in Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)...  Boston Scientific has released the primary endpoint ... Failure (NECTAR-HF) clinical trial, the first and only ... (VNS) for the treatment of heart failure patients.  ... Cardiology and Director of the Clinical Investigation Center ... de la Recherche Medicale presented the results at ...
(Date:8/30/2014)... Aug. 30, 2014   Royal Philips  (NYSE: PHG, ... a new ultrasound system designed to enable global ... increasing patient volumes and cost pressures. Making its debut ... in Barcelona this week, Affiniti ... patients with fewer resources deliver high quality patient care. ...
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire-iReach/ -- Market Research ... Industry, 2009-2019 is a professional and in-depth market ... Scanner industry . The report firstly reviews the ... classification, application and manufacturing technology. The report then ... Crystallography Scanner listing their product specification, capacity, Production ...
Breaking Medicine Technology:Boston Scientific Announces Primary Endpoint Results of NECTAR-HF Clinical Trial 2Boston Scientific Announces Primary Endpoint Results of NECTAR-HF Clinical Trial 3Boston Scientific Announces Primary Endpoint Results of NECTAR-HF Clinical Trial 4Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 2Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 3Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 2X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 3X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 5
(Date:9/1/2014)... honor of National Take Your Cat to the Vet Day, which ... Minnesota (AERC) is offering a few reasons why pet owners should ... don’t take their cat to the vet because “there’s nothing wrong” ... not to take their kid to dentist because he or she ... Just like people want their loved ones to be healthy, they ...
(Date:9/1/2014)... involved in federally-filed Tylenol lawsuits ( http://www.tylenollawsuitclaims.com/ ) are ... where issues related to claims involving the pain reliever ... Bernstein Liebhard LLP reports. , According to a ... the meeting is scheduled to take place on September ... of several Tylenol conferences that have taken place this ...
(Date:9/1/2014)... 2014 Registration is now open for the ... 1-Mile Race to be held on Sunday, September 21, 2014. ... at Harmon Meadow in Secaucus, New Jersey. All proceeds from ... nonprofit dedicated to restoring a sense of self, restoring the ... our military families. , General registration is $30 with special ...
(Date:9/1/2014)... Top10BestSEOHosting.com has recently compared many web ... carefully, Top10BestSEOHosting.com is here to announce that JustHost, ... suppliers in 2014. , JustHost ( http://www.justhost.com/track/seohosts ) ... shared hosting plan. The company’s approach to hosting ... affordable, accessible and powerful enough for anyone to ...
(Date:9/1/2014)... Las Vegas, NV (PRWEB) September 01, 2014 ... for entrepreneurs and online marketers that was developed to ... campaign, has caught the attention of Shane Michaels, prompting ... even established entrepreneur, the daily duty of managing all ... online business can be quite overwhelming,” reports Michaels. “That’s ...
Breaking Medicine News(10 mins):Health News:Animal Emergency & Referral Center of Minnesota Celebrates National Take Your Cat to the Vet Day 2Health News:Animal Emergency & Referral Center of Minnesota Celebrates National Take Your Cat to the Vet Day 3Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 2Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 3Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 4Health News:Hope For The Warriors New Jersey Run to Honor Wounded and Families of the Fallen 2Health News:Why Top10BestSEOHosting.com Calls Them Great Web Hosting Suppliers 2Health News:Ontraport: Review Exposes Automated Platform for Online Marketing Management 2
... -- The brains of people with autism concentrate more resources ... in areas used to plan and control thoughts and actions, ... people with autism have exceptional visual abilities, said the researchers ... 26 brain imaging studies that were conducted over 15 years ...
... Breast cancer risk can be assessed by examining ... preliminary study results presented at the AACR 102nd Annual ... method has the potential to provide a personalized assessment ... Arcaro, Ph.D., associate professor of veterinary and animal sciences ...
... Langone Medical Center have investigated a novel protein test ... accurately identify proteins secreted from cancerous tumors caused by ... Association for Cancer Research 102nd Annual Meeting 2011 on ... under the sponsorship of the National Cancer Institute,s Early ...
... , SUNDAY, April 3 (HealthDay News) -- New ... heart attack four years after the city was devastated ... Chronic stress, not being able to return home and ... situation, said the researchers, who updated their two-year post-Hurricane ...
... Health Study revealed that diabetes is associated with lower risk ... other cancers in both men and women. The data, to ... here April 2-6, also showed an association between diabetes and ... an association between diabetes and an increased risk for cancers ...
... SATURDAY, April 2 (HealthDay News) -- In a small preliminary ... number of episodes of a potentially dangerous irregular heartbeat known ... week also improved quality of life, lowering levels of the ... according to research to be presented Saturday at the annual ...
Cached Medicine News:Health News:Brains of People with Autism Focus More on Visual Skills 2Health News:Breast milk may provide a personalized screen of breast cancer risk 2Health News:New test detects early-stage, asbestos-related pulmonary cancer 2Health News:Heart Attack Risk Plagues Post-Katrina New Orleans 2Health News:Avoiding or controlling diabetes may reduce cancer risk and mortality 2Health News:Yoga May Also Calm a Dangerous Irregular Heartbeat 2Health News:Yoga May Also Calm a Dangerous Irregular Heartbeat 3
... The Laserex Tango ophthalmic laser system provides ... SLT laser and a photodisruptor for posterior ... a frequency-doubled Nd:YAG producing pulsed 532 nm ... producing 1064 nm. The appropriate laser can ...
Extremely thin and smooth jaws, jaws open to 5.5 mm, cross action....
Round handle....
5 mm concave jaws, cross action....
Medicine Products: