Navigation Links
Zafgen Announces New Weight Loss and Safety Data from Phase 2 Study of Beloranib in Obesity at Obesity Week 2013
Date:11/15/2013

were allowed to eat normally and were not counseled to change their diet or exercise habits.

Results from this study showed that after 12 weeks of treatment, subjects on 0.6 mg, 1.2 mg, or 2.4 mg of beloranib lost on average (+/- standard error of mean) -5.5 +/- 0.5 kg, -6.9 +/- 0.6 kg, and -10.9 +/- 1.1 kg, respectively vs. -0.4 +/- 0.4 kg for those on placebo (all p<0.0001 vs. placebo).  The study also showed that weight loss with beloranib was progressive and continuing at week 12, reduced sense of hunger, improved cardiometabolic risk markers, and was generally well-tolerated.  In addition to confirming the findings from previous studies that showed improvements in LDL-cholesterol, HDL-cholesterol and triglycerides, this study also demonstrated beloranib's effects to lower blood pressure.  Using 24-hour Ambulatory Blood Pressure Monitoring, clinically and statistically significant improvements in systolic blood pressure were observed for the 1.2 mg and 2.4 mg doses, showing reductions of 7.6 mmHg and 12.0 mmHg, respectively.

There were no serious adverse events (AEs) deemed to be related to the study drug and no clinically significant abnormal laboratory measures, vital signs, or electrocardiography (ECG) findings.  The most common adverse events with a higher incidence rate in those taking beloranib vs. placebo were nausea, diarrhea, headache, injection site bruising, and insomnia.  These adverse events were generally mild, transient and self-limiting in nature.

"These full Phase 2 results are an exciting prospect for the treatment of severely obese patients," said Louis Aronne, M.D., Clinical Professor of Medicine at Weill Cornell Medical College.1 "Beloranib continues to demonstrate a unique ability to deliver rapid and significant weight loss as well as meaningful improvements in key cardiometabolic risk markers.  Based on this supporting data, beloranib has the
'/>"/>

SOURCE Zafgen, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Zafgen Announces Initiation of Phase 2a Clinical Development with Beloranib in Obesity
2. Zafgen Secures $21 Million in Series D Financing
3. Precision Optics Corporation Announces $1 Million Order for Microprecision™ Based Endoscopes
4. Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012
5. JDRF Announces Research Collaboration with Dexcom, Inc. to Develop "Smart Transmitter" Technology to Accelerate Artificial Pancreas Studies
6. Misonix Announces New Distribution Agreement For Panama
7. University of Maryland BioPark Announces MedImmunes Dr. Bahija Jallal as Newest Member of Board of Directors for UM Health Sciences Research Park
8. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
9. Boston Scientific Announces CE Mark and European Launch of Emerge™ PTCA Dilatation Catheter
10. Soligenix Announces Further Progress with ThermoVax™ for Long-Term Vaccine ThermoStability
11. Masimo Announces New Low-Profile Infant and Neonatal Pulse Oximetry Sensors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... , Aug. 20, 2014  Amerigen Pharmaceuticals Ltd. announces ... Ltd., has received Chinese FDA (CFDA) approval and ... Tablets into the China ... and distribution agreement with Sinochem Jiangsu Pharmaceutical Co., ... US FDA approved and China CFDA certified oral ...
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com announces ... in its catalogue: The Market for ... The European, Middle Eastern and African ... devices. As part of its coverage, this study: ... on the EMEA medical device markets and estimates ...
(Date:8/20/2014)... , Aug. 20, 2014 ... research report is available in its catalogue: ... Records http://www.reportlinker.com/p0833392/EMR-2014-The-Market-for-Electronic-Medical-Records.html ... for electronic medical records (EMR) for nearly a ... report of our findings. Our report has become ...
Breaking Medicine Technology:Amerigen Pharmaceuticals Ltd. announces that its Chinese subsidiary, Suzhou Amerigen Pharmaceuticals Co. Ltd., has received Chinese FDA (CFDA) approval and has subsequently launched its generic Mecobalamin 0.5 mg Tablets into the China domestic mark 2The Market for Medical Devices in EMEA 2The Market for Medical Devices in EMEA 3The Market for Medical Devices in EMEA 4The Market for Medical Devices in EMEA 5EMR 2014: The Market for Electronic Medical Records 2EMR 2014: The Market for Electronic Medical Records 3EMR 2014: The Market for Electronic Medical Records 4EMR 2014: The Market for Electronic Medical Records 5EMR 2014: The Market for Electronic Medical Records 6EMR 2014: The Market for Electronic Medical Records 7EMR 2014: The Market for Electronic Medical Records 8
... April 25, 2011 The 2010 Pharmacy Today ... American Pharmacists Association , reveals pharmacists believe that ... was recommended by their pharmacist, 92% of pharmacists walk ... a product selection and the average patient consult takes ...
... Scientific Corporation (NYSE: BSX ) today ... and launch of the ION™ Paclitaxel-Eluting Platinum Chromium ... technology.  The ION Stent System incorporates a unique ... stenting and intended to improve the acute performance ...
Cached Medicine Technology:Pharmacists Offer Guidance on Top Over-The-Counter Medications 2Pharmacists Offer Guidance on Top Over-The-Counter Medications 3Boston Scientific Announces FDA Approval and U.S. Launch of ION™ Platinum Chromium Stent System 2Boston Scientific Announces FDA Approval and U.S. Launch of ION™ Platinum Chromium Stent System 3Boston Scientific Announces FDA Approval and U.S. Launch of ION™ Platinum Chromium Stent System 4Boston Scientific Announces FDA Approval and U.S. Launch of ION™ Platinum Chromium Stent System 5
(Date:8/20/2014)... common cause of endophthalmitis, a potentially blinding condition that ... injections, are the well-known staphylococci ("staph") and ... study published in the August issue of Ophthalmology ... of cases at New York Eye and Ear Infirmary ... found that gram-positive bacteria, which include staph and strep ...
(Date:8/20/2014)... The non-small cell lung cancer (NSCLC) market value ... the top 8 developed nations, from just over USD ... billion by 2020-end, posting a CAGR of 6.6% during ... driven by innovative therapies entering the squamous cell carcinoma ... the non-squamous segment. Thus, patients with SCC are expected ...
(Date:8/20/2014)... Caddis Partners LLC, has built one of the ... company in recent years, developing or acquiring 2 million ... including more than $100 million last year alone. , ... new geographic regions and a wider array of product ... announce an enhanced brand identity that includes a new ...
(Date:8/20/2014)... Angeles, CA (PRWEB) August 20, 2014 ... it is bringing on Wrench Advisors as a ... tasks including international large accounts. , As Wrench ... sales consultants can help your organization plan and ... executives and global distribution channels. Our experience developing ...
(Date:8/20/2014)... The award-winning plastic surgery group, The Aesthetic Center ... Houston to a third office, located in Katy, Texas ... ACPS plastic surgeon Dr. Rolando Morales said the expansion ... risen to become one of the largest, most respected ... its establishment in 1996 by plastic surgeons Dr. Christopher ...
Breaking Medicine News(10 mins):Health News:Researchers pinpoint most common causes of dangerous eye infection post surgery and trauma 2Health News:Researchers pinpoint most common causes of dangerous eye infection post surgery and trauma 3Health News:Top 8 Developed Nations NSCLC Market to Grow at CAGR of 6.6% Through 2020, Says GBI Research in Its Report Published at MarketPublishers.com 2Health News:Top 8 Developed Nations NSCLC Market to Grow at CAGR of 6.6% Through 2020, Says GBI Research in Its Report Published at MarketPublishers.com 3Health News:Top 8 Developed Nations NSCLC Market to Grow at CAGR of 6.6% Through 2020, Says GBI Research in Its Report Published at MarketPublishers.com 4Health News:Caddis Rebrands to Emphasize Its Growth, Expanded Capabilities 2Health News:Caddis Rebrands to Emphasize Its Growth, Expanded Capabilities 3Health News:Caddis Rebrands to Emphasize Its Growth, Expanded Capabilities 4Health News:Biocide Systems Announces Partnership with Wrench Advisors 2Health News:Aesthetic Center for Plastic Surgery Expands Its Reach in Texas 2
... Vision ... Expand Access to Care, WASHINGTON, April 9, 2008 ... health care,policy issues by doctors of optometry from his district ... in West Virginia and the AOA are working to pass ...
... 9 Nu Skin Enterprises,Inc. (NYSE: NUS ) ... the market opening on Thursday, May 1, 2008., ... a,conference call with the investment community later that same ... can expect to hear,management review past results and discuss ...
... housework, is good for mental health , , WEDNESDAY, April 9 (HealthDay ... clean your house and boost your mood. , In ... activity a week helped mental health, although the more vigorous the ... published online Thursday in the British Journal of Sports Medicine ...
... 9 The following statement,was issued today by William ... York,s leaders have taken historic action to protect the ... use by increasing,the state cigarette tax by $1.25 to ... tax increase ever enacted and gives New York the,highest ...
... One month of tough breathing may help asthma sufferers breathe ... University of Houston professor. , In a move ... Hippocratic Oath first do no harm Richard Bond, ... long-standing medical taboo to treat asthma. Although counterintuitive, Bonds ...
... may also identify children at risk , , WEDNESDAY, April ... responsible for cardiac hypertrophy (thickening of the heart muscle) ... this rare but life-threatening condition in children, says a ... children who had no family history of the condition, ...
Cached Medicine News:Health News:Sen. Robert Byrd Receives AOA Health Care Leadership Award 2Health News:Whisk Those Blues Away 2Health News:New York Cigarette Tax Increase Delivers Victory for Kids and Taxpayers 2Health News:First do no harm? UH prof taking opposite approach to treat asthma 2Health News:First do no harm? UH prof taking opposite approach to treat asthma 3Health News:First do no harm? UH prof taking opposite approach to treat asthma 4Health News:Gene Mutations for Rare Heart Disease Also Found in Kids 2
Sedillot periosteal elevator, 16 mm, sharp, 7"....
Periosteal elevator #9H, 17.5 cm, 7"....
Obwegeser periosteal elevator, angled, 9 mm, 20 cm, 8"....
... The Anterior Isola System is ... scoliotic, lordotic or kyphotic spinal ... stiff fixation bridge parallel to ... spine. The system, developed for ...
Medicine Products: