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Zafgen Announces Initiation of Phase 2a Clinical Development with Beloranib in Obesity
Date:11/6/2012

ing," Steven R. Smith, M.D., scientific director of the Florida Hospital-Sanford Burnham Translational Research Institute for Metabolism and Diabetes[1], said.  "This new trial will evaluate how the effects of this novel therapy extend with longer treatment in patients with type 2 diabetes, an important obesity-related co-morbid condition, and will be an important scientific milestone in shaping its use in the treatment of obesity and its related conditions." 

Results from the next clinical development phase are anticipated to be available in June 2013.  For more information about the study, visit ClinicalTrials.gov.

About Fat Metabolism

Research continues to show that obese and lean individuals metabolize fat differently.  Studies indicate that once a person becomes obese, the body undergoes certain metabolic changes and is "programmed" to create and store more fat, making it much more difficult to reduce body weight.  These metabolic adaptations that take place in obese people impair the normal release and breakdown of fatty acids from adipose tissue.  Simultaneously, the body becomes much more efficient in diverting calories from food and storing them as fat.

About Beloranib

Beloranib is the first compound in its class that works by targeting a key enzyme called MetAP2 that controls the production and utilization of fatty acids.  Inhibitors of MetAP2 reduce the production of new fatty acid molecules by the liver and help to convert stored fats into useful energy.  Beloranib is being developed as a twice-weekly subcutaneous injection for severe obesity.  Zafgen holds exclusive worldwide rights (exclusive of Korea) for development and commercialization of beloranib.  The company licensed beloranib from CKD Pharma.

About Zafgen, Inc.

Zafgen is an innovative company dedicated to addressing the unmet need of severely obese patients by bringing beloranib, a first
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SOURCE Zafgen, Inc.
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