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YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY
Date:3/13/2009

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The poster presentation will also include data describing the similar anti-tumor effects of nimotuzumab and cetuximab against EGFR-overexpressing tumors. Nimotuzumab's requirement for bivalent binding (similar to conditions that make Herceptin(R) effective), limits the accumulation of nimotuzumab to tissues with higher EGFR density (principally occuring in tumors).

"This research, together with the accumulating clinical data on nimotuzumab, demonstrate that, where tumors over-express EGFR naturally, or are stimulated to over-express EGFR by radiation-containing regimens, nimotuzumab would be expected to have similar efficacy to Erbitux(R) and Vectibix(R)," explained David Allan.

The authors conclude that toxicities of Erbitux(R) should not be viewed as markers for clinical benefit of EGFR-targeting antibodies in general, but only as markers of indiscriminate targeting of that particular antibody, with the EGFR blockade of normal cells by the marketed antibodies disrupting the cell's function. This finding is especially important in view of the recent papers describing the underreporting of the toxicities of Erbitux(R), particularly Grade IV radiation dermatitis in head and neck cancer, reportedly not previously observed with radiation alone. These presentations by YM help to demonstrate the nature of differentiation of nimotuzumab from the other anti-EGFR antibodies and show that its intrinsic properties confer a wide therapeutic window compared to Erbitux(R) and thus, in contrast to it, nimotuzumab is a more precisely targeted therapy.

The AACR abstract builds on a presentation by YM at the AACR Translational Medicine conference held in June 2008, which demonstrated that, in tumor cells expressing moderate-to-high levels of the EGF receptor, nimotuzumab has binding equivalent to the currently marketed EGFR-targeting antibodies. The AACR 2009 presentation includes data demonstrating equivalent anti-tumor effects of nimotuzumab and cetu
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SOURCE YM BioSciences Inc.
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