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Xiangxue Pharmaceuticals to Acquire Rights for a Promising Drug Candidate from Kinex Pharmaceuticals for the Greater China Territory
Date:5/21/2012

BUFFALO, N.Y., May 21, 2012 /PRNewswire/ -- Kinex Pharmaceuticals, LLC and Xiangxue Pharmaceuticals announced today the execution of a license agreement from Kinex Pharmaceuticals granting Xiangxue Pharmaceuticals exclusive rights to KX02, for all oncology indications, in the greater China territory (China, Hong Kong, Taiwan) and Singapore.

KX02, a lipophilic dual src/pretubulin inhibitor, was discovered and developed by Kinex Pharmaceuticals through their internal R&D efforts. It is a small molecule that has shown potent inhibitory activity against a broad panel of brain tumor cell lines, including cells (T98G) that are resistant to Temodar, the most widely used chemotherapy for the treatment of malignant glioma. In a well-established brain tumor animal model, KX02 has been shown to consistently clear brain tumors after 4 weeks of therapy in 30-60% of treated animals. Pharmacokinetic studies showed that KX02 is absorbed orally  and has 76% penetration to brain tissue from plasma. Mechanistic studies showed that KX02 induced both surface and central necrosis of the glioma compared to Temodar which only induced surface necrosis. All preclinical studies, including toxicology studies in two animal species, essential for the filing of investigational new drug application (IND) to the US Food and Drug administration (FDA), have been completed. Kinex Pharmaceuticals is planning to file an IND in early third quarter of 2012 to initiate phase 1 clinical studies. The intellectual property of KX02 as a new chemical entity is protected by issued patents until February 2026.          

The acquisition of rights to develop drugs in certain Asian territories is part of Xiangxue Pharmaceuticals overall business strategy to expand their small molecule franchise, including their effort to work on new drug development, into those regions that have intellectual property protection. This strategy is in li
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SOURCE Kinex Pharmaceuticals
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