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Xeomin® (incobotulinumtoxinA) Data To Be Presented At The 71st Annual Assembly Of The American Academy Of Physical Medicine And Rehabilitation
Date:11/5/2010

e speed at which accessory proteins disassociate from the neurotoxin molecule at physiological pH suggests that the necessity of these proteins in medicinal formulations of botulinum toxin type A is questionable in influencing the therapeutic effects," said Eric J. Pappert, M.D., Vice President of Medical Affairs, Merz Pharmaceuticals, LLC. "Additionally, results from the stability studies evaluating XEOMIN under various conditions suggest that accessory proteins are not required for the long-term maintenance of potency of this medicinal formulation of botulinum toxin type A."

Clinical StudiesThe results of studies exploring the safety and efficacy of XEOMIN in the treatment of adults with cervical dystonia, blepharospasm and post-stroke spasticity of the upper limb will also be presented:

  • Poster 49: Efficacy and safety of NT 201 (Xeomin®; Botulinum neurotoxin free from complexing proteins) in cervical dystonia (Grafe S., et al.)
  • Poster 50: Efficacy and safety of NT 201 (Xeomin®; Botulinum neurotoxin type A free from complexing proteins) for the treatment of blepharospasm: Results of a double-blind, placebo-controlled, randomized, multi-center trial (Jankovic J., et al.)
  • Poster 57: Overall clinical efficacy and overall tolerability of NT 201 (Botulinum neurotoxin free from complexing proteins) (Benecke R., et al.)

  • About XEOMINIn nature, Clostridium botulinum produces the toxin in association with accessory proteins, resulting in a 900 kDa complex. Manufacturers utilize this naturally occurring protein complex to produce therapeutic botulinum toxin products. Merz has introduced XEOMIN (incobotulinumtoxinA), manufactured using a proprietary process that isolates the therapeutic component and eliminates accessory proteins, yielding a 150 kDa neurotoxin molecule.

    More than 84,000 patient shave been treated with XEOMIN worldwide since 2005. The U.S. is the 20th country to approve XEOMIN for the trea
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    SOURCE Merz Pharmaceuticals
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