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Xenon Licenses Antisense Drug XEN701 From Isis and Initiates Preclinical Toxicology Studies
Date:6/10/2013

CARLSBAD, Calif. and VANCOUVER, British Columbia, June 10, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) and Xenon Pharmaceuticals Inc. announced today that Xenon has exercised its option  to an exclusive worldwide license to XEN701, an antisense drug discovered in a collaboration between Isis and Xenon.  For the license of XEN701, Isis earns a $2 million payment from Xenon.  XEN701 is a drug candidate designed to inhibit the production of hepcidin, a target Xenon identified utilizing its extreme genetics platform for the treatment of anemia of chronic disorders (ACD).  XEN701 is currently being evaluated in studies to support clinical development.  Xenon plans to initially develop XEN701 for patients with chronic kidney disease who are intolerant of or who are poor responders to erythropoietin (Epo) therapy. XEN701 is the first drug to enter development from Isis' collaboration with Xenon.

"We are delighted with the advances we have made with Isis to discover XEN701," said Simon Pimstone, Xenon's President and CEO. "XEN701 has the potential to provide significant therapeutic benefit to patients with ACD through a novel non-Epo receptor based mechanism and we are looking forward to initiating clinic studies with this compound."

"We are pleased with the success of our collaboration with Xenon and the opportunity to apply our antisense drug discovery technology to discover XEN701, a novel antisense drug to treat ACD," said B. Lynne Parshall, chief operating officer at Isis.  "A key component of our business strategy is to exploit the broad applicability of our antisense technology platform in order to develop antisense drugs in many different therapeutic areas.  By working with partners like Xenon, who are highl
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SOURCE Isis Pharmaceuticals, Inc.
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