Navigation Links
XTL Biopharmaceuticals Presents Data Regarding its Hepatitis C Virus Small Molecule Program at Hep Dart 2007 - an International Scientific Conference on Viral Hepatitis
Date:12/10/2007

VALLEY COTTAGE, N.Y., Dec. 10 /PRNewswire-FirstCall/ -- XTL Biopharmaceuticals Ltd. (Nasdaq: XTLB, TASE: XTL) announced today that it will make two scientific presentations related to its pre-clinical Hepatitis C virus (HCV) small molecule program at HEP DART 2007, an international scientific conference on viral hepatitis being held this week in Lahaina, Hawaii.

A poster presentation entitled "Mechanistic Characterization of Potent Small Molecule HCV Inhibitors that Target NS5A" describes a family of small molecule inhibitors of HCV that target the NS5A viral protein. Potency of these compounds was evaluated in a replicon assay, which is known to have good correlation with clinical efficacy and is the current gold standard for pre- clinical testing of inhibitors of HCV. In the replicon assay, the compounds had single-digit nM (nanomolar) and low double-digit nM potencies against genotypes 1b and 1a, respectively. These genotypes constitute the majority of HCV infections in the U.S.

New data presented further substantiate NS5A as the target of these compounds. The new data includes results from in vitro binding to NS5A, resistance selection, molecular genetic and molecular modeling studies.

NS5A is a viral protein that is essential for RNA production and is distinct from the protease and polymerase - the viral targets of the more advanced HCV inhibitors in clinical development. As such, inhibitors of NS5A are considered promising candidates for the treatment of HCV. As a relatively new target, only one NS5A inhibitor has entered clinical trials to date - A831 - which is presently in a Phase 1 clinical trial. A831 was developed by Arrow Therapeutics, which was recently acquired by AstraZeneca. The Company's compounds pr
'/>"/>

SOURCE XTL Biopharmaceuticals Ltd.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. WallSt.net (www.wallst.net) Updates the Investment Community Through an All-New Interview With RegeneRx Biopharmaceuticals CEO
2. Nabi Biopharmaceuticals Announces Second Quarter 2007 Financial Results
3. Nabi Biopharmaceuticals Announces Continued Positive NicVAX Phase 2b Data at Nine Months
4. Keryx Biopharmaceuticals to Present at William Blair & Company Small-Cap Growth Stock Conference
5. Morria Biopharmaceuticals Plc Initiates Phase I Clinical Study of MRX-4 in Allergic Rhinitis
6. Keryx Biopharmaceuticals, Inc. Announces Positive Preliminary Phase 2 Data on KRX-0401 in Patients with Chemo-Insensitive Rare Sarcoma
7. Nabi Biopharmaceuticals Announces Successful Completion of NicVAX(R) Phase 2b Trial; Drug Shows Statistically Significant Rates of Smoking Cessation and Continuous Long-Term Smoking Abstinence at 12 Months
8. Inspiration Biopharmaceuticals Announces Filing of IND for Novel Recombinant Factor IX Product, IB1001, for the Treatment of Hemophilia B
9. Keryx Biopharmaceuticals, Inc. Announces Phase 1 and Phase 2 Data on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Multiple Myeloma at 49th Annual Meeting of American Society of Hematology
10. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
11. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)...  Halozyme Therapeutics, Inc. (NASDAQ: HALO ... Drug Administration (FDA) has removed the clinical hold ... SWOG,s ongoing Phase 1b/2 clinical trial (S1313). The ... PEGPH20 (PEGylated Recombinant Human Hyaluronidase) in combination with ... pancreatic adenocarcinoma.  The study will resume under a ...
(Date:9/18/2014)... 2014 Australian biomarker discovery company Minomic International ... its MiStat™ prostate cancer screening test, planning to achieve ... completion. Minomic,s proprietary MiStat™ technology is a ... proprietary biomarker known as the MIL-38 antigen. This biomarker ... Researchers at 11 leading urology centres ...
(Date:9/18/2014)... , Sept. 18, 2014 /CNW/ - A new expert ... Canada , released today by the ... safe and effective medicines for children. Each year about ... children use at least one prescription drug. Much of ... from the authorized use), creating potential health risks. ...
Breaking Medicine Technology:SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 2SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 4Minomic Launches US Pilot Study of MiStat(TM) Novel Prostate Cancer Screening Technology 2Studying medicines in children is always possible and is in their best interest, finds Expert Panel 2Studying medicines in children is always possible and is in their best interest, finds Expert Panel 3
... 17, 2011 Pharmatek Laboratories, Inc., a premier ... industry, announced that it has been approved by ... the analysis of Schedules I through V controlled ... manufacture drug products containing Schedules IV and V ...
... 2011 The U.S. Food and Drug Administration today ... with methotrexate, for the treatment of active systemic ... years and older. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ... a rare, potentially life-threatening disorder in children that ...
Cached Medicine Technology:Pharmatek Granted Approval by the DEA for Analysis of All Controlled Substances 2FDA Approves Actemra to Treat Rare Form of Juvenile Arthritis 2FDA Approves Actemra to Treat Rare Form of Juvenile Arthritis 3
(Date:9/18/2014)... Schaumburg, IL (PRWEB) September 18, 2014 ... proving itself a boon to contractors and homeowners ... construction dust that overtakes the home, causes potential ... project. Now available nationwide, the BuildClean system allows ... from demolition, sanding and other standard remodeling tasks. ...
(Date:9/18/2014)... VA (PRWEB) September 18, 2014 Results ... just been released and it reveals that pornography is ... and also harms marriages. The findings are based upon ... ) and conducted by Barna Group among a nationally ... survey included numerous questions focusing upon the frequency of ...
(Date:9/18/2014)... Randy Dotinga HealthDay Reporter ... who have the largest number of post-traumatic stress disorder symptoms ... to food, a new study suggests. The findings ... or becoming addicted to food. And it,s also possible that ... PTSD, or both. Still, the research seems to ...
(Date:9/18/2014)... Recently, WowBobble.com, the popular online supplier of funny ... to its product line. Moreover, all the company’s products ... customers can enjoy the special offer before September 29, 2014. ... prices ($12.5 for each bobblehead doll ). , ... bobbleheads. We want to make our interesting items available to ...
(Date:9/18/2014)... September 18, 2014 A positive outlook on ... improve your health. This year, at the Weekend for Women ... that adored LA radio talk show host Mother Love will ... with diabetes. , The always-funny Jo Anne Hart, aka ... best known for her widely acclaimed talk show on LATalkRadio.com, ...
Breaking Medicine News(10 mins):Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 2Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 3Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 4Health News:2014 Study shows that pornography is an addiction that risks employment and harms marriages 2Health News:2014 Study shows that pornography is an addiction that risks employment and harms marriages 3Health News:2014 Study shows that pornography is an addiction that risks employment and harms marriages 4Health News:2014 Study shows that pornography is an addiction that risks employment and harms marriages 5Health News:PTSD Link to Food Addiction Seen in Report 2Health News:PTSD Link to Food Addiction Seen in Report 3Health News:Discounted Custom Bobbleheads Online For Sale At WowBobble.com 2Health News:DiabetesSisters Showcases Radio Talk Show Host Mother Love at Weekend for Women Conference in Los Angeles 2
... male and rural most likely to face obstacles, research ... veterans continue to meet barriers as they seek treatment ... and 2008, nearly 50,000 veterans from the Iraq and ... fewer than 10 percent of those completed the recommended ...
... , NEW YORK , ... ), the leading source of health information, today announced a ... in diagnosis and treatment at the point-of-care. Medscape Mobile, WebMD,s ... of in-depth clinical reference articles on diseases, conditions, and procedures, ...
... DALLAS Feb. 15, 2010 Simple urine tests for ... in people with lupus, researchers at UT Southwestern Medical Center ... take years before such tests could be used clinically, the ... currently in use, the researchers said. "Our goal was ...
... ... with healthcare companies to develop customized, corporate branded accredited programs for patient safety, fall ... ... MedicalNurseTraining.com announces an exciting new way to bundle Health Care Brands as an ...
... ... Atlanta-based Premier Anesthesia to manage the anesthesia services for its hospital and surgery center. ... Alpharetta, GA ... has contracted with Atlanta-based Premier Anesthesia to manage the anesthesia services for its hospital ...
... , LYON, France ... a new line of TCS 7560 and TCS 7561 Silbione(R) ... applications (support,stockings and medical equipment). These two new silicone elastomers ... (Photo: http://www.newscom.com/cgi-bin/prnh/20100216/377913 ) , ...
Cached Medicine News:Health News:WebMD Launches New Version of Free Mobile Application for Physicians 2Health News:WebMD Launches New Version of Free Mobile Application for Physicians 3Health News:WebMD Launches New Version of Free Mobile Application for Physicians 4Health News:Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find 2Health News:Medical Nurse Training, Inc. Partners With Healthcare Companies to Develop Corporate Branded, Accredited Programs for Patient/Bed Safety and Fall Prevention/Protection 2Health News:Premier Anesthesia Forges New Partnership with Texas Hospital 2Health News:Bluestar Silicones Launches a New Range of Silbione(R) TCS 7560 & 7561 Elastomers for Lingerie, Support Stockings and Medical Textile Applications 2
... two-piece Titanium (Ti-6Al-4V) screw offered in two ... of lengths. The two pieces are loaded ... A single instrument set contains all items ... Standard and Mini Kompressor Compression Screws. , ...
... The cornerstones of the Acutrak family ... Screw Systems. Together they are used primarily ... of the upper extremity, but have been ... The bones stabilized with these two systems ...
... combined with the IRIS Medical OcuLight ... consoles,the EasyView slit lamp adapter (SLA) ... laser photocoagulation,to your existing Haag-Streit slit ... and glaucoma,without compromising the diagnostic functions ...
... revolutionized the wrist arthroplasty market with the ... We're at it again, with the release ... Like the original, the Universal2 System continues ... debilitating arthritis. To date, we now have ...
Medicine Products: