Navigation Links
Wyeth's TORISEL Receives European Commission Approval for the Treatment of Advanced Kidney Cancer
Date:11/26/2007

In the study, TORISEL significantly increased median overall survival by 49 percent compared with interferon-alpha (10.9 months vs. 7.3 months, P=0.0078). TORISEL also was associated with a statistically significant improvement over interferon-alpha in the secondary endpoint of progression-free survival (when the disease does not worsen; 5.6 months vs. 3.2 months, P=0.0042). The combination of TORISEL and interferon-alpha did not result in a significant increase in overall survival when compared with interferon-alpha alone.

"The European Commission's approval of TORISEL underscores the importance of this therapy for patients with advanced kidney cancer and reinforces the potential of this mechanism of action as a new approach in oncology," says Robert R. Ruffolo, Jr., Ph.D., President, Wyeth Research, and Senior Vice President, Wyeth.

About TORISEL

TORISEL is an mTOR inhibitor indicated in the European Union for the first-line treatment of patients with advanced RCC who have at least three of six prognostic risk factors. These risk factors include less than one year from time of initial RCC diagnosis to randomization, Karnofsky performance status of 60 or 70, hemoglobin less than the lower limit of normal, corrected calcium of greater than 10 mg/dL, lactate dehydrogenase > 1.5 times the upper limit of normal, and more than one metastatic organ site. In the United States, TORISEL is indicated for the treatment of advanced RCC.

Inhibition of mTOR in treated cancer cells blocked the translation of genes that regulate the cell cycle. In in vitro studies using renal cancer cell lines, TORISEL inhibited the activity of mTOR and resulted in reduced levels of certain cell growth factors involved in the development of new blood vessels, such as vascular endothelial growth factor.

In March 2007, the European Association of Urology published guidelines recommending that TORISEL be considered as first-line treatment in patients with advanced
'/>"/>

SOURCE Wyeth Pharmaceuticals
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Wyeths Torisel and Roche/Genentechs Avastin Will Challenge Pfizers Sutent to Become the Clinical Gold Standard for Treatment of Metastatic Renal Cell Carcinoma
2. Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis
3. Indevus Receives Approvable Letter From FDA for VALSTAR(R) for Bladder Cancer Therapy
4. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
5. Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test
6. GlaxoSmithKline Receives New HHS Order for H5N1 Bulk Antigen. First North American Clinical Trials with GSKs Candidate Pre-pandemic Flu Vaccine to Start.
7. CryoCor Receives FDA Approval for Right Atrial Flutter
8. Ranbaxy Receives Approval to Manufacture and Market Hydrocodone Bitartrate and Acetaminophen Tablets USP
9. Dimericine(R) Receives FDA Fast Track Designation for Treatment Of Photosensitivity in XP Patients
10. Poniard Pharmaceuticals Receives FDA Fast Track Designation for Picoplatin for Treatment of Small Cell Lung Cancer
11. Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Germany , Aug. 21, 2014  IBM (NYSE: ... Elektronen-Synchrotron ( DESY ), a leading national research center ... management and storage of massive volumes of x-ray data. ... based on IBM software defined technology can handle more ... performance and help scientists worldwide gain faster insights into ...
(Date:8/21/2014)... BreedIT Corp., (OTCQB: BRDT) ... worldwide license holder and distributor of highly sophisticated ... today is pleased to announce the formation of ... a leading Israeli medical Cannabis breeder. ... breeds of medical Cannabis to meet the requests ...
(Date:8/21/2014)... 2014  Armada Health Care (Armada), the nation,s ... pleased to announce an agreement with Aurora Health ... innovative specialty pharmacy patient program offerings. The new ... services to specialty patients via Armada,s proprietary ReachRx ... will use the OTM platform as its case ...
Breaking Medicine Technology:DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 2Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 3
(Date:8/21/2014)... York (PRWEB) August 21, 2014 ... C.R. Bard, Inc. continue to move forward in ... Court, Southern District of West Virginia, Bernstein Liebhard ... on August 14th, the Court has established new ... requires special handling, division, storage and preservation. (In ...
(Date:8/21/2014)... Seattle, WA chiropractors Dr. Lincoln Kamell and ... Massage Center have recently welcomed two new massage ... LMP and Mike Larios, LMP have specialized training and ... have developed their expertise working in a variety of ... a clinical environment where massage is used on its ...
(Date:8/21/2014)... primary care physicians in rural communities do not ... according to Penn State medical and public health ... violence have limited resources if they seek help., ... help women," said Jennifer S. McCall-Hosenfeld, a primary ... public health sciences, Penn State College of Medicine. ...
(Date:8/21/2014)... August 21, 2014 The results of ... in The Journal of the American Medical Association (JAMA) ... cancers and reduces unnecessary recalls. Memorial Healthcare System was ... study. , “This study confirms what we already know ... cancers we want to find and, at the same ...
(Date:8/21/2014)... UK (PRWEB) August 21, 2014 The ... USD 15.6 billion in 2014 and reach USD 18.3 ... the forecast period. The drivers of such growth include ... rising obese and diabetic population, and surging ageing population. ... of state-of-the-art wound care products. Region-wise, North America leads ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 3Health News:Seattle’s Eastlake Chiropractic and Massage Center Is Pleased to Introduce Rina Lang and Mike Larios as New Members of Its Massage Therapy Team 2Health News:Seattle’s Eastlake Chiropractic and Massage Center Is Pleased to Introduce Rina Lang and Mike Larios as New Members of Its Massage Therapy Team 3Health News:Primary care physicians can be critical resource for abused women in rural areas 2Health News:Dr. Mary Hayes: Study Shows 3D Mammography Finds More Invasive Cancers While Reducing Unnecessary Recalls 2Health News:Global Wound Care Market to Post 3.2% CAGR Through 2019, Says MarketsandMarkets in Its New Report Published at MarketPublishers.com 2Health News:Global Wound Care Market to Post 3.2% CAGR Through 2019, Says MarketsandMarkets in Its New Report Published at MarketPublishers.com 3
... 5, 2011 The new edition of America Speaks, ... demonstrates increasing public support for research and innovation to ... nearly 60% of Americans don,t believe we are making ... the U.S. has the best health care system in ...
... -- By gluing together cells from different genomes to form ... chimeric monkeys. In the report published online and ... said the monkeys, who are made up of as many ... successfully implanting these genetically mixed rhesus monkey embryos into mothers, ...
... HealthDay Reporter , THURSDAY, Jan. 5 (HealthDay News) ... annoying and painful but ultimately harmless problem -- a result ... a hangover after a night of drinking. But frequent ... known as gastroesophageal reflux disease, or GERD, and GERD is ...
... More than half of U.S. jails didn,t receive any vaccine ... flu, a new study says. Jail and prison inmates ... steady stream of new arrivals can introduce new types of ... for diseases to spread, researchers from the U.S. Centers for ...
... been linked to depression, according to UT Southwestern Medical ... It is believed to be the largest such investigation ... are associated with a cavalcade of health woes from ... published in Mayo Clinic Proceedings helps ...
... , THURSDAY, Jan. 5 (HealthDay News) -- Toddlers who ... disorders later in life, a new study indicates. Researchers ... found that depriving them of a single daily nap resulted ... reduced problem-solving abilities. "Many young children today are not ...
Cached Medicine News:Health News:Majority of Americans say research and development are key to building US economy 2Health News:Scientists Create First Monkeys With Mixed Genomes 2Health News:Chronic Heartburn a Growing Problem in U.S. 2Health News:Chronic Heartburn a Growing Problem in U.S. 3Health News:Many Jails Got No Flu Shots During H1N1 Outbreak: CDC 2Health News:Low vitamin D levels linked to depression, UT Southwestern psychiatrists report 2Health News:Missed Naps Could Put Toddlers at Risk for Mood Disorders 2
This adjustable-volume digital micropipet is used to accurately measure and transfer small solution volumes in the 100-1,000 microliter range....
... Pipettor is the #1 Pipettor for ... comfort, and reliability. Continuously adjustable. Features ... sub-micrometer. Easy interchangeable ejector buttons to ... Adjustable rapid pipet tip ejector with ...
... adjustable, air-displacement pipette with a patented multifunctional ... of the Pipetman family, sharing many of ... We also added a number of features ... models cover the full range of volumes ...
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
Medicine Products: