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Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations
Date:5/22/2008

ting effects. Because of its chemical structure, RELISTOR does not affect the opioid-mediated analgesic effects on the CNS.

About Subcutaneous RELISTOR

On April 24, 2008, the United States Food and Drug Administration approved RELISTOR subcutaneous injection for the treatment of OIC in patients with advanced illness who are receiving palliative care, when response to laxative therapy has not been sufficient. The use of RELISTOR beyond four months has not been studied. Wyeth expects to make subcutaneous RELISTOR available in the United States in early June. Subcutaneous RELISTOR has also been approved in Canada and is awaiting Australian approval and European approval, having received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP), the EMEA scientific committee, in April.

Important Safety Information for Subcutaneous RELISTOR

-- RELISTOR is contraindicated in patients with known or suspected

mechanical gastrointestinal obstruction.

-- If severe or persistent diarrhea occurs during treatment, advise

patients to discontinue therapy with RELISTOR and consult their

physician.

-- Use of RELISTOR has not been studied in patients with peritoneal

catheters.

-- The most common adverse reactions with RELISTOR in clinical trials were

abdominal pain, flatulence, and nausea.

RELISTOR Prescribing Information is available at http://www.relistor.com.

About the Collaboration

In December 2005, Wyeth and Progenics Pharmaceuticals entered into an exclusive, worldwide agreement for the joint development and commercialization of methylnaltrexone for the treatment of opioid-induced side effects.

About the Companies

Wyeth Pharmaceuticals, a division of Wyeth, has leading products in the areas of women's health care, infectious disease, gastrointestinal health, central nervous
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SOURCE Wyeth Pharmaceuticals
Copyright©2008 PR Newswire.
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