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Wyeth Presents Phase 3 Fracture Data for Bazedoxifene, an Investigational Therapy for Osteoporosis
Date:9/19/2007

acture Risk in Postmenopausal Women with Osteoporosis: Results from a Three-Year, Randomized, Placebo- and Active-Controlled Clinical Trial," which enrolled 7,492 postmenopausal women between the ages of 55 and 85 with moderate to severe osteoporosis, bazedoxifene showed significant risk reduction, compared with placebo, for new vertebral fractures. Specifically, the three-year incidences of new vertebral fracture were 2.3 percent, 2.5 percent, 2.3 percent and 4.1 percent in the bazedoxifene 20 mg, bazedoxifene 40 mg, raloxifene 60 mg and placebo groups, respectively.

In addition, a subgroup analysis of 1,782 women at higher risk for fracture showed that bazedoxifene significantly reduced the incidence of non- vertebral fracture. In particular, the non-vertebral fracture incidence was 3.0 percent, 3.8 percent, 5.9 percent and 6.3 percent in bazedoxifene 20 mg, bazedoxifene 40 mg, raloxifene 60 mg and placebo groups, respectively, with a risk reduction of 46 percent, compared with placebo, when both bazedoxifene doses were combined.

About Osteoporosis

According to the National Osteoporosis Foundation, the number of women of menopausal age who have osteoporosis or are at risk for developing the disease will increase from almost 30 million in 2002 to nearly 41 million by 2020. Osteoporosis causes approximately 1.5 million fractures each year in the United States alone, and the risk of fracture significantly increases in women usually after age 50. Non-vertebral fractures are more common than vertebral fractures and account for an estimated 300,000 hip and 250,000 wrist fractures, in addition to an estimated 250,000 fractures at other non- vertebral sites such as the clavicle, humerus, pelvis and leg.

About Wyeth Pharmaceuticals

Wyeth Pharmaceuticals, a division of Wyeth, has leading products in the areas of women's health care, infectious disease, gastrointestinal health, central nervous system, inflammation, transplantation, hemophilia, o
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SOURCE Wyeth Pharmaceuticals
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