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Women Clear Winners with Heart Failure Device
Date:5/13/2010

70 Percent Reduction in Heart Failure; Double the Benefit of Men

ROCHESTER, N.Y., May 13 /PRNewswire-USNewswire/ -- For women with mild heart failure, device therapy is an extremely attractive option to prevent progression of the disease, according to a study presented today at the Heart Rhythm Society's 31st Annual Scientific Sessions. Women with mild heart disease who had a cardiac resynchronization device combined with a defibrillator (CRT-D) implanted had a 70 percent reduction in heart failure alone and a 72 percent reduction in death from any cause. Men received some benefit from the therapy, but not the out-of-the-park results seen in women.

"This is the first study in which a heart failure therapy has proven more effective in women than in men," said cardiologist Arthur Moss, M.D., professor of Medicine at the University of Rochester Medical Center and lead author of the study.

The study is a sub-analysis of the MADIT-CRT trial, which was published last year in the New England Journal of Medicine. Researchers found that females receiving CRT-D therapy to prevent heart failure progression had significantly better outcomes than males receiving the therapy. Reduction of heart failure in females was twice that of males – 70 percent versus 35 percent. While women saw a significant 72 percent reduction in death from any cause, there was no evident reduction in men.

This gender-based analysis comes less than two months after an advisory panel to the U.S. Food and Drug Administration recommended that the device, which is developed by Boston Scientific, be approved for use in patients with mild heart failure. The device is already approved to treat patients with sev
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SOURCE University of Rochester Medical Center
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