Navigation Links
With Bone Marrow Transplants Rising, New Therapy Gives Hope to Those Over 55
Date:1/8/2014

NEW YORK, Jan. 8, 2014 /PRNewswire/ -- Bone marrow transplants are a $1.3 billion market and the fastest-growing hospital procedure in the U.S. They are the only potential cure for many blood cancers such as acute myeloid leukemia (AML) in older patients. The procedure is technically called hematopoietic stem cell transplantation (HSCT) and can be either a bone marrow transplant (BMT) or transplant of blood stem cells isolated from peripheral blood (PBSC). In either case, it involves transplanting cells capable of restoring normal bone marrow function into a patient.

An increasing number of HSCT patients are over age 55, but many in this group who need it are ruled ineligible. This is because the high-dose chemotherapy traditionally preceding HSCT—standard therapy for younger patients—is often deemed too harsh even for healthy looking older people. Indeed, in certain indications, less than 10 percent of those 55+ survive more than a year after conventional HSCT.

Since more than half of AML patients are over 65 years old, new tactics are needed. For example, what if a patient's existing bone marrow could be "prepared" prior to the transplant in a way that eliminated the need for high-dose chemotherapy? This promising approach is being pursued by an innovative New York City-based biotech company, Actinium Pharmaceuticals, Inc.

Actinium's lead compound, Iomab™-B, has been successfully harnessed as a "myeloconditioning" agent in Phase 1/2 trials involving more than 250 patients including cases of incurable blood cancers such as AML resistant to available therapies. It has demonstrated the ability to prepare such patients for bone marrow transplants when no other treatment was indicated. The targeting part of Iomab™-B is a monoclonal antibody that targets CD45, an antigen widely expressed on white blood cells but not on other tissues.

Very significantly, treatment with Iomab™-B prepares a patient for bone marrow transplant in only 10 days, compared to approximately six weeks required with traditional care—a potentially vital difference in the face of a fast-evolving cancer.

"The only potentially curative treatment option for older AML patients is bone marrow transplant, but the majority of patients over age 55 are ineligible for conventional care due to health reasons and/or severity of their disease," says Kaushik J. Dave, Ph.D., President and CEO of Actinium Pharmaceuticals, Inc. "We believe Iomab™-B offers a positive step toward their continued treatment. Almost all patients are eligible, and preliminary studies indicate their survival rates are significantly higher as a result. It also can help prepare older patients for bone marrow treatment who have survived chemo but whose AML either was not cured or returned."

On the strength of results showing its potential in Phase 1/2 trials, the company is poised to begin a Phase 3 trial during 2014. The primary endpoint will be the rate of durable complete remission among the treated patients. A series of physician-led trials involving Iomab™-B is also ongoing.

For more information, visit www.actiniumpharmaceuticals.com, who paid for the writing and dissemination of this release.

Contact:  Laura Radocaj, Dian Griesel Int'l.  212.825.3210


'/>"/>
SOURCE Actinium Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Enlivex Therapeutics Publishes Positive Results from Phase I/II Clinical Trial for the Treatment of Bone Marrow Transplant Recipients
2. Chimerixs Antiviral CMX001 Abstract Selected for an Oral Presentation at the European Group for Blood and Marrow Transplantations Annual Meeting
3. The Princess Margaret BMT Program Chooses Remedy Informatics Blood and Marrow Transplant & Cell Therapy Solutions to Power their fight Against Cancer
4. Adoption of Prefillable Syringes Rising, Especially In High-cost Drug Applications to Contain Wastage, Notes Frost & Sullivan
5. Scioderm Initiates Phase 2B Study of SD-101, A Novel Topical Therapy, for Patients with Epidermolysis Bullosa
6. Alpha and Omega Gene Therapy Eye Creams Scientific Blend Removes Years of Damage
7. FDA Clears the Provant Therapy System for Use by Patients with Metallic Implants
8. Norgine and Innovacell Enter Into an Exclusive Licensing Agreement for ICEF15 - An Innovative Personalised Cell Therapy to Treat Faecal Incontinence
9. NW Bio Responds To Shareholder Inquiries Following Immune Therapy Sectors Recent Market Decline
10. FDA Issues Complete Response Letter for Canagliflozin/Metformin Fixed-Dose Combination Therapy for Type 2 Diabetes
11. Novartis highlights research on investigational, personalized T cell therapy CTL019 in patients with forms of acute and chronic leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... FDA 510(k) clearance covers Confocal Miniprobes ... and surgical applications Mauna Kea Technologies ... multidisciplinary confocal laser endomicroscopy (CLE) platform, today announced ... the 12 th 510(k) clearance from United ... FDA clearance covers Confocal Miniprobes indicated for use ...
(Date:5/25/2016)... , Germany and GERMANTOWN, ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: ... licensing and co-development agreement with Therawis Diagnostics GmbH to develop ... be to develop and market PITX2 as a marker to ... high-risk breast cancer patients. "We are pleased to ...
(Date:5/25/2016)... , May 25, 2016 ... Size, Share, Development, Growth and Demand Forecast to 2022 ... Insulin Pump and Others)" published by P&S Market Research, ... $9,998.3 million in 2015, and it is expected to ... on type, the insulin pump segment is expected to ...
Breaking Medicine Technology:
(Date:5/28/2016)... ... ... a part of the city where’s it’s easy to spot the neon lights of chains ... to attract diners with a taste for real food. , On May 13, the ... Grill, an urban casual restaurant focusing on dishes made by hand with wholesome, organic ingredients ...
(Date:5/27/2016)... ... May 27, 2016 , ... W.S. Badger Co. Inc ... that it has been recognized as one of the best small businesses for new ... as one of nine small businesses providing progressive benefits to new parents on the ...
(Date:5/27/2016)... ... May 27, 2016 , ... An educational ... by inspiring human-interest stories, courtesy of awareness-driven celebrities and thought leaders. It also ... advocates, associations and industry leaders such as Bioness. , As patients feel ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... Aimed at ... human interest stories, which come courtesy of leaders in the nursing and health care ... from leading advocates and associations—namely Abilene Christian University. , As the nursing industry ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... There are ... Hot Dog and Sausage Council (NHDSC) suggests that Americans prefer their dogs straight off ... 63 percent say grilling is their favorite way to cook a hot dog, far ...
Breaking Medicine News(10 mins):