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Winners Announced in 2010 Collegiate Inventors Competition®
Date:10/27/2010

roperty commented.  "They are not only bright innovators but embody the spirit of entrepreneurship, which has always fueled our economy and created jobs.  At this critical time for our nation, this year's winners strengthen our belief that America's best days lie ahead."

Graduate winner Alice Chen knew that although mice are widely used in medical research, they are often not helpful for pharmaceutical testing.  The liver is where many drugs are broken down, or metabolized, and mouse livers and human livers metabolize substances differently.  Chen has developed a way to implant human liver cells in mice.  Her approach is different from other techniques in that she implants a matrix that contains functioning human liver cells and the nutrients they need directly into a healthy mouse.  The matrix, once implanted, performs functions much like a human liver, making it beneficial for drug testing and other therapeutic applications. Chen, 29, is currently a doctoral candidate in Harvard-MIT's joint program in Health Sciences and Technology.  

Second place graduate winners Erez Lieberman-Aiden and Nynke van Berkum call their invention Hi-C, showcasing how DNA is folded into the nucleus of a cell in an efficient and functional way.  Until this invention, researchers have been unclear on how a genome folds six-feet of itself into a tiny nucleus. The pair's three dimensional genome sequencing allows them to focus on questions about genome folding and how the folds change.  They speculate that aberrations in genome folding could relate to human disease, which would provide the potential to help prevent or treat devastating diseases such as cancer.  Third place winners Bozhi Tian and Tzahi Cohen-Karni have developed a tiny electronic cell probe that is capable of observing and monitoring the inner electrical workings of living cells.  This team's method allows them to use a V-shaped silicon nanowire as a fiel
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