The idea of a mega-Sirtuin1 gene activator (1000-fold gene booster), such as proposed by a pharmaceutical company, requires greater scrutiny because an engineered molecule that has never been used in humans is being employed and its safety profile is unknown, and because early animal studies show over-activation (7.5 fold) of Sirtuin1 produces unfavorable effects in laboratory animals (heart failure). Aging involves many genes, not just one gene.
Wine or pills?
In 1991 60 MINUTES was first to make Americans aware of The French Paradox, the fact the red-wine-drinking French exhibit 30% lower mortality rates from heart disease despite their high-fat, high calorie diet. Sales of red wine skyrocketed after that breakthrough 60 MINUTES TV report.
The approval of a pharmaceutical version of a red wine anti-aging pill may be years away, if it ever does gain approval, and its manufacturer concedes it may debut its Sirtuin1-gene activating drug as a companion with an anti-diabetic (metformin) or anti-cholesterol (statin) drug rather than as an anti-aging pill. A pill that more closely replicates the health benefits of red wine, without the alcohol, calories, sugar or sulfite preservatives, may be more desirable to many.
Such a pill would likely be more affordable than red wine. Three-to-five glasses of red wine cost about $3-5 for the most inexpensive red wine, while, for comparison, Longevinex(R) costs less than a dollar a day.
Intriguing evidence for unusual longevity attributed to red wine molecules is provided by researchers from
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