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Why Wait for an Anti-Aging Drug? Researchers Interviewed on CBS-TV's 60 MINUTES Discover Longevinex(R) Nutriceutical Matrix Activates 9-Fold More Longevity Genes than Plain Resveratrol
Date:1/25/2009

like the one employed by lead researcher Richard Weindruch PhD of LifeGen Technologies, provides a more rapid assessment of life-prolonging strategies.

The mouse has about the same number of genes as humans (~30,000) and many of its genes are in a similar position or exhibit a similar function.

Does Sirtuin1 activation prolong human life?

The idea that activation of a single gene -- Sirtuin1 -- may prolong human life, has faced a scientific rocky road since it was first proposed in 2003. Early on it was shown that resveratrol activated the SIR2 gene in simpler life forms and cause yeast cells, fruit flies and round worms to live longer. SIR2 is a gene that is similar to Sirtuin1 in humans.

But only recently have researchers at MIT come to realize the Sirtuin1 gene is not activated in all tissues and organs in calorie restricted animals, so it may not serve as a universal marker of calorie restriction. A growing number of recent research studies indicate resveratrol actually down-regulates the Sirtuin1 gene.

Resveratrol is not calorie restriction

Additionally, researchers recently reported resveratrol does not produce the same characteristic drop in body temperature and slowed heart rate seen in calorie restriction. So, plain resveratrol may not be a true mimic of the effects of calorie restriction.

Furthermore, researchers concede the Sirtuin1 gene was not activated in earlier studies. More Sirtuin1-gene derived proteins were found in calorie restricted animals because this intervention protected Sirtuin1 proteins from degradation.

Dosage is important

Finally, when mega-dose resveratrol was put to the test in the first study involving warm-blooded animals, the animals fed mega-dose resveratrol did not live as long as animals placed on a normal-calorie diet. Many resveratrol pills sold online and in retail stores suggest mega-doses
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