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When Prescribing New Drugs for Crohn's Disease or Ulcerative Colitis, Surveyed EU5 Gastroenterologists Will Prioritize Remission Rates Over Cost and Reimbursement Hurdles
Date:12/16/2013

proven superiority over appropriate comparators is increasingly required for optimal pricing and reimbursement. For example, based on indirect comparison with Remicade, interviewed payers believe that the clinical profile of vedolizumab in CD or UC is not strong enough to justify reimbursement before anti-TNFs if priced at a 25 percent or greater premium.

"While EU5 gastroenterologists expect vedolizumab to encroach on their use of anti-TNFs by the end of 2017, in the absence of a head-to-head trial showing evidence of superior efficacy that may justify use before anti-TNFs and with a potentially higher price, anti-TNFs will continue to dominate patient share," said Decision Resources Analyst Kathrina Quinn, Ph.D. "These data also reflect the expected entry of the more favorably priced biosimilar infliximab, which will bolster drug class share. At least 74 percent of surveyed gastroenterologists expect to prescribe biosimilar versions of Remicade within a year of availability for either CD or UC, but many are willing to do so under certain conditions only, such as if an acceptable safety and/or immunogenicity profile is shown."  

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