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Weight Loss and Effects on Diabetes with Qnexa Treatment Results Presented at the World Diabetes Congress
Date:12/7/2011

MOUNTAIN VIEW, Calif., Dec. 7, 2011 /PRNewswire/ -- VIVUS, Inc. (NASDAQ: VVUS) announced that an oral presentation was given at the International Diabetes Federation's World Diabetes Congress, in Dubai, United Arab Emirates today.  The presentation highlighted excess weight loss, improvement of glycemic parameters in diabetic patients with a BMI>35 and effects on diabetes status. This is the first World Diabetes Congress to be organized in the Middle East and North Africa Region - a region that is enormously affected by diabetes. The International Diabetes Federation (IDF) is an umbrella organization of over 200 national diabetes associations in over 160 countries.

The presentation, given by Nancy JV Bohannon, MD, FACP, FACE from the St Luke's Hospital, San Francisco, CA, USA, reported on a subset of patients within the CONQUER study who had diabetes and a BMI>35. Within this patient population (n= 147), excess weight loss, defined as the weight loss required to achieve a healthy BMI of 25,  was 33% with QNEXA as compared to 7.4% for the placebo group after 56 weeks of treatment (LS mean p<0.0001 compared to placebo).  Excess weight loss is typically reported in patients who have undergone weight loss surgery. Weight loss was highly correlated to improvements in glycemic parameters including fasting glucose (p<0.0001), fasting insulin (p=0.0024) and hemoglobin A1c (p<0.0001). Normalization of glucose levels and withdrawal of all antidiabetic medications occurred in 15% of patients treated with full dose QNEXA as compared to 2% with placebo (p=0.0287). The safety profile in this subpopulation, based on reported adverse events, is consistent with that seen in the whole study population.  The most common adverse events seen were constipation, upper respiratory infection, and tingling.

Dr. Bohannon stated that, "multiple options
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SOURCE VIVUS, Inc.
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