Navigation Links
Webinar Advisory: Regulus to Host Discussion About Potential of microRNA-33 as Target for Treatment of Atherosclerosis
Date:10/24/2011

f="http://www.microsoft.com">http://www.microsoft.com and at least a 56Kbps connection to the internet is required. If you experience problems listening to the webinar, please send an e-mail to: webcast@multivu.com.

About microRNA-33a/bmicroRNA-33a and b (miR-33a/b), which differ by only two nucleotides, are intronic microRNAs located  within the sterol response element binding protein genes SREBF2 and SREBF1, respectively, which code for transcription factors that regulate cholesterol homeostasis and fatty acid metabolism. Recent studies have shown that miR-33a/b regulates the cholesterol and fatty acid pathways in a negative feedback loop.  miR-33a/b represses the cholesterol transporter ABCA1 in hepatocytes and macrophages resulting in decreased cellular cholesterol efflux to apoA1, a key step in the generation of HDL-C and reverse cholesterol transport. Inhibition of miR-33 in mice, which only have miR-33a, resulted in an increase in expression of ABCA1 protein and increase in cholesterol efflux resulting in a reduction of atherosclerotic plaques (Rayner et al., J Clin Invest. 2011). In addition, miR-33a/b suppresses key enzymes involved in the oxidation of fatty acids resulting in the accumulation of triglyceride. Inhibition of miR-33a/b increases fatty acid oxidation and insulin signaling (Davalos et al., PNAS. 2011). These studies suggest that an anti-miR33a/b oligonucleotide treatment may be a promising strategy to treat atherosclerosis.  

About microRNAs The discovery of microRNA in humans during the last decade is one of the most exciting scientific breakthroughs in recent history. microRNAs are small RNA molecules, typically 20 to 25 nucleotides in length, that do not encode proteins but instead regulate gene expression. More than 700 microRNAs have been identified in the human
'/>"/>

SOURCE Regulus Therapeutics Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. FDA CONSUMER HEALTH INFORMATION - Oct. 20 Webinar—FDAs MedWatch System: How to Report Adverse Events
2. FDA Consumer Health Information - Sept. 30 Webinar: Prescription Drug Shortages
3. Jubilant HollisterStier Allergy Launches Allergy Industry Insights Educational Webinar Series
4. FDA Consumer Health Information - July 28 Webinar: Home Use of Medical Devices
5. Millennium Laboratories Launches New Educational Webinar Series for Pain Management Physicians
6. MedSolutions Offers Free CME Credit Imaging Safety Webinar for Physicians
7. Youth Suicide Prevention the Topic of Fall 2010 Series of Free Webinars from Well Aware
8. Advanced Data Systems Partners with 1450 and Dr. Ravi Venkataraman to Offer a Free EHR Webinar for Speech Recognition
9. Learn How Merck is Creating a Unified Culture and Company Brand During NewsGator Webinar Entitled: From MyMerck to OneMerck - Enterprise 2.0
10. Pacific Bridge Medical to Host Taiwan Drug Registration Webinar
11. Upcoming Webinar to Inform Public About Access to Investigational Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... is the daily "Profile America" feature from the U.S. ... Profile America — Tuesday, April 21st. One ... for general use this month in 1923, saving the ... is a hormone produced by the pancreas and is ... body. It was first isolated the year before by ...
(Date:4/20/2015)... 20, 2015 Actavis plc (NYSE: ... Mayr , Chief Communications Officer, will retire from ...  In conjunction with Mayr,s retirement, Alex Kelly ... of Chief Communications Officer, effective immediately. Prior to ... Vice President, Chief Communications Officer, Public Affairs and ...
(Date:4/20/2015)... , April 20, 2015   Precision Image ... series designed to highlight advances in cardiovascular imaging and ... president of the Society for Cardiovascular Magnetic Resonance ... will highlight improvements in patient management by providing broader ... presentation will help attendees to better understand appropriate use ...
Breaking Medicine Technology:U.S. Census Bureau Daily Feature for April 21 2Actavis Announces Retirement of Charles M. Mayr 2Actavis Announces Retirement of Charles M. Mayr 3Educational Webinar Teaches Improved Patient Management Through Broader Access to Cardiac MRI 2
... Decision Resources, one of the world,s leading ... finds that 98 percent of surveyed rheumatologists indicate they ... treatment of rheumatoid arthritis following the agent,s expected launch ... drug, more than 60 percent of these rheumatologists cite ...
... Arcadia Resources, Inc. (NYSE Amex: KAD ), a ... Arcadia HealthCare(SM) brand, today announced President and CEO Marvin R. ... Capital Markets Sixth Annual Healthcare Conference at 1:10 p.m. ET ... its story to institutional investors in a 25 minute presentation ...
Cached Medicine Technology:Ninety Eight Percent of Surveyed Rheumatologists Will Prescribe Roche's Actemra for Rheumatoid Arthritis 2Ninety Eight Percent of Surveyed Rheumatologists Will Prescribe Roche's Actemra for Rheumatoid Arthritis 3Arcadia Resources to Present at Lazard Healthcare Conference in New York 2
(Date:4/21/2015)... (PRWEB) April 21, 2015 Invictus ... a prestigious Illinois university for a second innovative ... (NICUs) more conducive to newborn infants’ cognitive development. ... three NICU problems we have identified through extensive ... professionals,” said George Hutchinson, Invictus Medical’s Chief Technology ...
(Date:4/20/2015)... When author Faith Canter was diagnosed with ... could wake her up - and she wasn’t alone. The ... living with CFS. , Rather than accepting her fate, Canter ... Life Less Toxic : The Whole Life Approach to Detoxifying ... Life for You, Your Family and Our Planet.” (published by ...
(Date:4/20/2015)... (PRWEB) April 21, 2015 Using Quality ... CMOs Speed Production and Improve Compliance , **FDAnews Webinar**, ... EDT, http://www.fdanews.com/qualitybydesign , The life sciences industries ... them to do more with less. Mergers, acquisitions, ... CMOs to finds ways to speed up production while ...
(Date:4/20/2015)... (PRWEB) April 21, 2015 The ... Susan Binau, Founder of Soul Care Group, Inc., ... Binau is recognized with this prestigious distinction for leadership ... 200 Local Chapters, NAPW is the nation's leading networking ... honor Susan with our Woman of the Year Award,” ...
(Date:4/20/2015)... The partners of Urgent Care of Westchester ... Diosa Laser Med Spa with a special event. Residents of ... from 12–7 p.m. on April 24 on 909 Midland Ave. ... refreshments. Participants will also get the chance to win free ... with any purchase, as well as up to 40 percent ...
Breaking Medicine News(10 mins):Health News:Invictus Medical Secures Rights to Second Promising New NICU Technology 2Health News:New book by Faith Canter offers guide to banishing toxins 2Health News:FDAnews Announces — Using Quality by Design to Improve Manufacturing: How Sponsors and CMOs Speed Production and Improve Compliance Webinar, May 7, 2015 2Health News:FDAnews Announces — Using Quality by Design to Improve Manufacturing: How Sponsors and CMOs Speed Production and Improve Compliance Webinar, May 7, 2015 3Health News:National Association of Professional Women Announces Susan Binau, Founder of Soul Care Group, Inc., a 2015 Professional Woman of the Year 2Health News:Bella Diosa Says Hello to Yonkers Community with Spa Party 2
... of 80 million dollars (60 million euros) to boost Kenya's ... in the country, an official statement said Wednesday. ... Control Council (NACC), the country's frontline agency in fighting the ... since 1984. ,"We are determined that the support ...
... will immunise 63 million children against measles in the biggest ... is one of the deadliest threats to young people in ... vaccination coverage here is currently only 69 percent. ... think it will show a lot of results," health minister ...
... Researchers at University of south Florida has found ... patients with rheumatoid arthritis which may lead ... to work and need for lifestyle modifications. ... patients degree of difficulty in performing activities of ...
... life comes with a price tag, especially when it comes ... anniversaries , other important dates and romantic gestures rack up ... average man would spend something close to 62 pounds a ... will spend up to 500 pounds to make sure that ...
... Dads at the top of the pecking order can rest assured ... a very different story when it comes to the daughters, especially ... on red deer has found that genes that may prove useful ... comes to their female offspring. ,The boffins also state ...
... authorities harried by the super bug Clostridium difficile (C diff), good ... of the hospital infection, researchers say. ,Clostridium difficile ... gut of around 3% of adults and 66% of children. ... some antibiotics that are used to treat other health conditions can ...
Cached Medicine News:Health News:Pakistan to Launch World's Biggest Anti-measles Drive 2Health News:Rheumatologists Underestimate the Patients Ability to Work 2Health News:Successful Dads Have Not So Successful Daughters 2Health News:Probiotic Drinks can Stave Off Hospital Infection 2
Double ended with 0.5mm x 10mm and 1.0mm x 15mm blades; both blades gently curved; round serrated handle, In Titanium....
0.5mm "K" hook. Rounded knurled handle; shaft angled 11mm from tip; overall length 120mm, in Titanium....
Bend with "H" Shaped Tip, Right; Stainless Steel....
The GE e-Speed™scanner, the worlds fastest computed tomography (CT) imaging platform, delivers a new advanced tool for physicians to see and diagnose heart disease....
Medicine Products: