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Waters Corporation and NIBRT Partner to Bring Greater Control and Predictability to Biopharmaceutical Processing
Date:5/6/2010

MILFORD, Mass. and DUBLIN, May 6 /PRNewswire/ -- Waters Corporation (NYSE : WAT) and Ireland's National Institute for Bioprocessing Research and Training (NIBRT) announced today a collaboration that will create the world's first database for glycan analysis by UltraPerformance Liquid Chromatography® (UPLC®). Expected to be available in 2011, NIBRT will develop, maintain and license the database while Waters and NIBRT will co-market it worldwide.

Manufacturing biomolecules can be notoriously difficult. Correct glycosylation is essential if a protein is to achieve and maintain its correct structure and therapeutic efficacy. Protein glycosylation is strongly influenced by many environmental factors during cell culture, such as dissolved oxygen, pH, carbon source, and temperature. Any change in any of these conditions at any point in the process can put product integrity at risk. So consistent glycosylation is a sensitive marker of a well-controlled process.

Given the number of possible glycan structures that can attach to a protein, it can be extremely difficult and time-consuming for life science laboratories to identify and quantify them all.

The new database, to be developed by Professor Pauline Rudd's group in NIBRT, will be a first-of-its-kind repository of chromatographic retention times for sets of glycan structures associated with a range of biotherapeutics. The aim is to give biopharmaceutical manufacturers
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SOURCE Waters Corporation
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