Navigation Links
Wacker Validates Scalability of Anticalin(R) Production With E.coli Secretion Technology and Will Produce Pieris First Clinical Candidate PRS-050
Date:7/17/2008

FREISING-WEIHENSTEPHAN and JENA, Germany, July 17 /PRNewswire/ -- Pieris AG, a bio-pharmaceutical company developing Anticalins(R), a novel class of targeted human protein therapeutics, and Wacker Biotech GmbH, a full-service contract manufacturer of biopharmaceuticals, announced yesterday a significant milestone in the development of Pieris' PRS-050 Anticalin(R) for clinical trials.

Pieris has developed PRS-050 as a next generation VEGF antagonist and as the first Anticalin(R) -based product in its proprietary pipeline. PRS-050 exemplifies many of the favourable characteristics of Anticalins(R): compact protein structure, high intrinsic stability, broad formulation flexibility and small molecular size improving the likelihood of effective target access. PRS-050 has already demonstrated potent inhibition of VEGF-induced enhanced vascular permeability and angiogenesis, as well as, anti-tumour activity and is expected to enter the clinic in 2009.

Wacker's proprietary E. coli secretion system is a well-established technology for the cost-efficient production of proteins. At the core of the technology is a proprietary E. coli K12-strain, developed by Wacker, to secrete recombinant proteins in native form. Production of clinically relevant proteins via direct extracellular secretion offers a far more cost effective approach to biopharmaceutical product manufacture than traditional protein refolding technologies.

Andreas Hohlbaum Ph.D., Chief Technology Officer of Pieris, stated: "Pieris has long-established expertise in small scale expression of Anticalins(R) for research use. As we progress our products to the clinic, we have established through our relationship with Wacker that an efficient production scale-up is possible. These excellent results and subsequent agreement with Wacker will expedite process development and GMP manufacture of Anticalins(R) for both proprietary and partnered products."

Thomas Maier Ph.D., Managing Director
'/>"/>

SOURCE Pieris AG
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. U.S. Patent Office Rejects Key HIV/AIDS Drug Patents at PUBPAT Request: Government Finds Prior Art Submitted By PUBPAT Invalidates All of Gilead Sciences Claims
2. Sarasotas Roskamp Institute Highlights Positive Japanese Data that Validates its Ongoing Alzheimers Disease Research
3. Pew Commission Says Industrial Scale Farm Animal Production Poses Unacceptable Risks to Public Health, Environment
4. Increasing Dairy Milk Production with Electrolyzed Drinking Water
5. SAIC Awarded Malaria Vaccine Production Support Contract Extension by the National Institute of Allergy and Infectious Diseases
6. New Study: Pine Bark Extract Boosts Nitric Oxide (NO) Production
7. Replidynes Investigational Antibacterial Agent REP3123 Prevents Toxin Production in Clostridium difficile
8. New Data Shows Ranexa(R) Increases Glucose-Stimulated Insulin Secretion
9. Echo Therapeutics Announces Publication of Positive Clinical Data for its Symphony Transdermal Continuous Glucose Monitoring System in Journal of Diabetes Science and Technology
10. Modigene Platform Validated in Independent Phase III Trial of CTP Technology
11. Embryo Viability Studies Support Utility of Novel, Metabolomic Profiling Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... After 6 months of careful research ... - the new programme for the next Cool Chain & ... global Cool Chain series, has just been released! ... As the lines between supply chain, logistics, QA and purchasing ... is broad and yet specific, focused and yet accessible, inclusive ...
(Date:9/18/2014)...  Spring Bank Pharmaceuticals, Inc., a clinical-stage biopharmaceutical ... RNA viruses, today announced a research collaboration with ... testing of the Company,s lead compound, SB 9200, ... against which currently there are no effective antiviral ... proprietary Small Molecule Nucleic Acid Hybrid (SMNH) ...
(Date:9/18/2014)... ROCKVILLE, Md. , Sept. 18, 2014 ... a biotechnology company with fully integrated commercial and drug ... oncology, and CASI Pharmaceuticals, Inc. (Nasdaq: CASI ... and commercialization of innovative therapeutics addressing cancer and other ... primary focus on China , announce ...
Breaking Medicine Technology:Europe's Biggest and Longest-Running Gathering of Life Sciences Logistics, Supply Chain & QA Professionals 2Spring Bank Pharmaceuticals Announces NIH Collaboration for Testing of SB 9200 Against Multiple Viral Pathogens 2Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 2Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 3Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 4Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 5Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 6Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 7Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 8Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 9Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 10
(Date:9/19/2014)... September 19, 2014 Yisrayl Hawkins, Pastor of ... expounding on the need to protect children. He begins by ... Michael Brown and reminds that there are many other children, ... says violence is spreading faster than cancer all over the ... “There are close to seven billion Michaels in the world ...
(Date:9/19/2014)... Los Angeles, California (PRWEB) September 19, 2014 ... a younger man for companionship and intimacy, and there are ... connection with an experienced, mature woman. SeekingCougar.com now ... , This online dating website caters to older women, and ... offers an easy and convenient way for these people to ...
(Date:9/19/2014)... VogueQueen.com has recently unveiled a ... ladies more beautiful at their weddings. The new range ... The company’s new products are made for the coming ... for all the global clients. , “The ... have ordered several items on its website. I'm very ...
(Date:9/18/2014)... (PRWEB) September 19, 2014 Reduce bags ... ingredients made just for these issues in a serum. ... Haloxyl and Eyeliss," says Kathy Heshelow, founder of Sublime ... circulation and boosting collagen, to improve the eye area." ... serum for wrinkles, dark circles and bags at ...
(Date:9/18/2014)... 18, 2014 Defendants in more ... currently pending in Pennsylvania’s Philadelphia Court of Common ... on behalf of out-of-state plaintiffs dismissed, Bernstein Liebhard ... 11th, the defendants maintain that circumstances surrounding the ... lawsuits have no connection to Pennsylvania. The filings ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Says the Michael Brown Scenario Will Continue Without Swift Action in New Post 2Health News:Dating Site "SeekingCougar.com" Now Offering Tips for Younger Men Seeking Older Women 2Health News:VogueQueen.com’s New Line Of Cheap Wedding Dresses Aims To Attract Chic Ladies 2Health News:The Secret to Improving Under-Eye Skin: 30% Off Sale and Report on Ingredients Ends Tonight on the Face Whisperer® Advanced Eye Gel 2Health News:Xarelto Lawsuit Defendants Seek to Have Pennsylvania Claims Filed by Out-of-State Plaintiffs Dismissed, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Defendants Seek to Have Pennsylvania Claims Filed by Out-of-State Plaintiffs Dismissed, Bernstein Liebhard LLP Reports 3
... study authored by a UT Southwestern Medical Center researcher has ... than a placebo in several other applications previously thought to ... of drugs used to increase red blood cells in patients ... in a study of 4,038 patients, it did little to ...
... ... therapy partner enlisting the public to send free treatment e-cards to the military and ... ... for a Healthier Life, today launched an online holiday program advancing the company,s commitment ...
... helps ID early breast cancer, 42 percent in study declined free ... high risk of breast cancer, an MRI can help detect malignancies ... 42 percent of such women in a new study said no ... wanted to have MRI, even though it was no cost to ...
... , ... saw exciting research progress, unprecedented opportunities on the horizon, and more ... economic and financial challenges, the National Multiple Sclerosis Society continues to ... provided over $33.5 million to support 345 new and ongoing projects ...
... MOINES, Iowa, Dec. 22 Palisade Systems, the leader in ... has completed internal certification of its PacketSure 7.6 service to ... services and software. , More and more companies are becoming ... recent article in eMarketer, close to 70 percent of small ...
... ... a comprehensive New Jersey anti-poverty charity, seeks year-end charitable contributions to meet an increasing need. ... Paterson, NJ (PRWEB) December ... Jersey during the current economic recession. By giving a charitable contribution to this trustworthy ...
Cached Medicine News:Health News:Anemia drug not helpful for kidney disease patients 2Health News:Prescription Audio Gives the Gift of Stress Relief This Holiday Season 2Health News:Prescription Audio Gives the Gift of Stress Relief This Holiday Season 3Health News:Many High-Risk Women Refuse Breast MRI 2Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 2Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 3Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 4Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 5Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 6Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 7Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 8Health News:Palisade PacketSure Certified for Twitter and Facebook 2Health News:Eva's Village, a Paterson, New Jersey Anti-Poverty Charity, Seeks End of Year Charitable Contributions to Help Poor in a Troubled Economy 2Health News:Eva's Village, a Paterson, New Jersey Anti-Poverty Charity, Seeks End of Year Charitable Contributions to Help Poor in a Troubled Economy 3
... This functional brace is designed for the ... and fibula. The preformed design provides post ... removal of internal or external fixation. The ... and below the fracture site, increasing vascularity ...
... Brace features a multi-axial hinge that duplicates ... altering kinematics. The infinite degree of adjustment ... and extension control of the knee. , ... tibia in correct anatomical alignment. The precision ...
... is a revolutionary cast replacement system for ... leg and foot. , ,A self-adjusting ... and in conjunction with a rigid lattice ... time of fracture or rupture healing can ...
... the constant demands of mobilizing patients quickly. ... necessary to fit bilateral KAFO's.,The complete kit ... knee joints , 4 Copolymer thigh support ... bands , Ortho-wick™ Padding for thigh , ...
Medicine Products: