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VolitionRX to Begin Prospective Clinical Trial in Colon Cancer
Date:8/21/2012

SINGAPORE, Aug. 21, 2012 /PRNewswire/ -- VolitionRX Limited, a life sciences company focused on developing blood-based diagnostic tests, announces that its subsidiary Belgian Volition has signed an agreement with the Biobank of CHU UCL Mont-Godinne, an academic hospital in Yvoir, Belgium. This is the fourth large-scale external clinical trial for VolitionRX. The trial will begin in early September, and is scheduled for completion next year. The trial will be a prospective longitudinal study including approximately 250 patients as they progress through diagnosis and treatment. The project aims to develop and clinically evaluate non-invasive blood tests for early detection and prognosis of colorectal cancer.

Patient recruitment and sampling will take place in the Gastro-Enterology and Oncology Departments of the CHU UCL Mont-Godinne Hospital. Patients with a potential digestive pathology (including a mixture of suspected colorectal cancer, polyp, inflammatory bowel disease ("IBD"), Crohn's disease and colitis) will be given a blood test alongside a colonoscopy. Samples will be taken from the following cohorts:

  • Patients with positive colonoscopy for IBD or polyp: initial sample plus a follow-up blood test
  • Patients with positive colonoscopy for cancer, and treated as follows:
    • Surgery only: initial samples followed by a further blood sample approximately one month after surgery;
    • Surgery followed by chemotherapy: initial sample followed by further samples pre and post chemotherapy treatment rounds;
    • Chemotherapy followed by surgery: initial sample followed by further samples pre and post chemotherapy treatment rounds and surgery;
  • Patients with negative colonoscopy for IBD, polyp or cancer will form an age-matched healthy control cohort.

Belgian Volition will analyze the samples using its NuQ™ kits, at its
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SOURCE VolitionRX Limited
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