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VolitionRX Limited Issues Update Letter to Shareholders
Date:10/31/2011

the Wallonian Government in Belgium, whose support allowed us to open our laboratory at the Unite de Recherche en Biologie Cellulaire – FUNDP in Namur, Belgium. This lab has proved to be invaluable for speedy proof of concepts, scientific focus, and product development. We have seen extremely promising results coming out of our lab in recent months, and in September we announced the filing of three new patents. We now hold five Nucleosomics™ patent applications, one granted and four pending (two patent applications are licensed from external sources – the European Molecular Biology Laboratory and Chroma Therapeutics Limited – and three are Volition-authored). We also hold a HyperGenomics™ patent application which is licensed from Imperial College London and an application for a patent for a test for endometriosis, which is also based on our Nucleosomics™ technology. We believe we will file several more patents as our team continues to make breakthroughs.

We have also made applications to register trademarks in the U.S. and Europe for our key technologies to give us the basis for the branding of our products.  

We have also made progress in our currently non-core technologies, HyperGenomics™ and Endometriosis, and will focus on developing these technologies in early 2012 once we have our NuQ products on the market. We have created a separate subsidiary, HyperGenomics Pte Limited, to allow HyperGenomics to develop separately from our core products. We anticipate that we will finalize the development plans for the subsidiary in Q1 of 2012 assuming the results of testing underway are positive.

The team has been working hard validating cancer samples using our Nucleosomics™ tests and we have seen extremely promising results to date.  Our NuQ-X™ test for the detection of nucleosomes containing specific nucleotides have shown 100% accuracy in cancer patients, and our NuQ-V™ tests for
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