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Volcano Sponsors First Study Designed to Determine if IVUS Can Identify Patients at Risk for Stent Thrombosis and to Demonstrate the Benefit of IVUS Guidance for Procedural Outcome
Date:10/22/2007

3,000 Patient Multi-center IVUS Sub-study Part of the Cardiovascular Research Foundation's ADAPT-DES Study to Quantify Causes and Cures of Drug

Eluting Stent Thrombosis

SAN DIEGO, Oct. 22 /PRNewswire-FirstCall/ -- Volcano Corporation (Nasdaq: VOLC) [TCT Booth #2013 Level 2], a leading manufacturer of intravascular ultrasound (IVUS) and functional measurement (FM) technology, announced today its sponsorship of the first major study designed to examine the role of IVUS in ensuring accurate stent placement. The 3,000 patient IVUS sub-study is part of the Cardiovascular Research Foundation's (CRF) ADAPT-DES study (Assessment of Dual AntiPlatelet Therapy with Drug-Eluting Stents), a prospective, multi-center registry of 11,000 (and up to 15,000) patients with coronary artery disease undergoing stent-assisted percutaneous coronary intervention (PCI) using drug-eluting stents (DES). The study's main objectives are to determine the frequency, timing and correlates (clinical, angiographic and IVUS) of DES thrombosis and the relationship of aspirin and/or clopidogrel hyporesponsiveness, and general platelet reactivity to early and late DES thrombosis.

"Although the benefits of IVUS have been anecdotally discussed by many interventional cardiologists and quantified in a number of published studies, the additive value of IVUS measures as independent predictors of stent thrombosis beyond the information present from clinical and angiographic variables has not been assessed in a prospective, multi-center registry," commented Gregg W. Stone, MD, Principal Investigator of ADAPT-DES and Chairman of the Cardiovascular Research Foundation. "The ADAPT-DES IVUS sub-study is expected to provide def
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SOURCE Volcano Corporation
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