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Volcano Announces Preliminary Results from the ADVISE II Study and Inclusion in the SYNTAX2 Trial During Hot Line Late Breaking Clinical Trial Sessions at EuroPCR 2013
Date:5/23/2013

d to test precision guided percutaneous coronary intervention (PCI), using a clinical SYNTAX score as derived at Cardialysis in Rotterdam along with live iFR®/FFR Hybrid measurements of the vessel to determine which patients and lesions are treated. Boston Scientific SYNERGY™ drug-eluting stents will then be placed with IVUS guidance, using both Volcano and Boston Scientific IVUS devices, to provide more accurate stent placement than has been demonstrated with angiography alone.  

"Modern-day stent design and techniques have improved dramatically since the very first SYNTAX study was enrolled more than five years ago," commented Professor Patrick Serruys , Rotterdam, Netherlands. "It is widely believed in the community that PCI is an excellent alternative to coronary bypass surgery in the right patients. The SYNTAX2 study will use a new 'clinical SYNTAX score' to first identify prospective patients we believe will benefit from a less-invasive PCI procedure, and then use physiology and IVUS guidance along with the modern-day drug-eluting stent technology. The goal is to show that delivering the most precise and modern-day PCI possible will allow more patients to be treated with this excellent alternative to bypass surgery." 

"The fact that iFR has now been validated in more than 3,000 patients as part of these studies makes us comfortable in our understanding of the performance of the tool," commented Michel Lussier , President of Scientific and Clinical Affairs at Volcano. "iFR is not a replacement for FFR given the wealth of outcome data generated over the years in DEFER, FAME and FAME II. Future studies like SYNTAX2 that include iFR will now focus on clinical, economic and quality of life outcomes rather than comparisons to FFR now that those questions have been answered. This is an exciting time and we
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