Navigation Links
Vitamin E Improves NASH
Date:10/31/2009

ALEXANDRIA, Va. and BOSTON, Oct. 31 /PRNewswire/ -- In a randomized, double-blind, placebo-controlled trial of 247 patients who had NASH but not diabetes, pioglitazone improved key histological features and liver enzymes; however, vitamin E was more successful for the treatment of NASH in these patients.

NASH is associated with fatty liver disease, insulin resistance, and obesity, and it is estimated that 3 to 4 percent of Americans have NASH. The disease progresses to inflammation in the liver and in 15 to 20 percent of those patients to cirrhosis. There is no current treatment for this common disease.

In this study presented at the annual meeting of the American Association for the Study of Liver Diseases, patients were randomized into three groups and given pioglitazone (an insulin-sensitizer), vitamin E, or a placebo. At the end of the study, 19 percent of patients in the placebo group, 34 percent in the pioglitazone group, and 43 percent in the vitamin E group met the primary endpoint, which was a predetermined histological improvement and no worsening of fibrosis.

According to the study's author, Arun Sanyal, MD, of the Virginia Commonwealth University, vitamin E for the treatment of NASH had shown some success in smaller studies, but this was the first large study to be successful. The upside to this, according to Dr. Sanyal, is that, "Not only did vitamin E improve liver function in 40 percent of the patients treated with it, but the specific type of vitamin E used in the study is inexpensive, readily available, and caused no side effects in patients who participated in the study."

Abstract title:

A randomized controlled trial of Pioglitazone or vitamin E for nonalcoholic steatohepatits (PIVENS)

AASLD is the leading medical society focused solely on advancing the science and practice of hepatology and represents more than 3,300 practitioners, researchers, and allied health professionals worldwide. Founded by physicians in 1950, AASLD has upheld the standards of the profession and fostered research that generates treatment options for the millions of patients with liver diseases.

This year's Liver Meeting, held in Boston, Massachusetts, October 30 - November 3, will bring together more than 7,000 researchers from 55 countries. A pressroom will be available from October 31 at the annual meeting. For copies of abstracts and press releases, or to arrange for pre-conference research interviews contact Gregory Bologna at 703-299-9766. To pre-register, call Ann Tracy at 703-299-9766.

Press releases, additional information for the media, and all abstracts are available online at www.aasld.org.

    Media Contact: Gregory Bologna
    703/299-9766
    gbologna@aasld.org

    Press Room: October 31 - November 3, 2009
    Hynes Convention Center, Room 209
    Telephone: (617) 954-2827

    Researcher: Arun Sanyal, MD
    Email: asanyal@mcvh-vcu.edu
    Phone: (804) 828-6314

This release was issued through The Xpress Press News Service, merging e-mail and satellite distribution technologies to reach business analysts and media outlets worldwide. For more information, visit http://www.XpressPress.com

SOURCE American Association for the Study of Liver Diseases


'/>"/>
SOURCE American Association for the Study of Liver Diseases
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. FDA: Procter & Gamble Unlawfully Marketing Two Vicks Cold and Flu Medicines Containing Vitamin C
2. VitaminSpice Appoints Dr. Richard F. Seelig as Director
3. July 2009 Mayo Clinic Womens HealthSource Highlights Food Storage Safety, Energy Therapies and Vitamins and Minerals
4. Study Suggests Vitamin D Screening and Appropriate Supplementation Indicated for All Cancer Patients
5. Researchers Say More Aggressive Vitamin D Supplementation Needed in Obese Cancer Patients
6. Harvard Study Shows Folic Acid, B Vitamins in Animi-3(R) May Prevent Vision Loss
7. Evidence Lacking in Multivitamin Study of Womens Risk of Cancer, Heart Disease or Death, Says Natural Products Association
8. Mission Pharmacal Launches CitraNatal(R) Assure Prescription Prenatal Vitamin
9. Emisphere Presents Dramatic Clinical Evidence Demonstrating New Approach to Vitamin B12 Supplementation
10. Scientists Reveal Roadmap to Brain Health That Can Be Passed Down to Future Generations: Exercise, Omega-3, Folic Acid, Vitamin B6, and Vitamin B12
11. Free Prostate Cancer Seminar in Lake Ridge, VA: Dr. Charles Snuffy Myers Announces Vitamin D Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... 2017  ivWatch LLC, a medical device company focused ... therapy, is pleased to announce it was the Bronze ... Supplies and Equipment at the 2017 Medical Design Excellence ... industry. The award was presented by Medical Device and ... in New York during MD&M ...
(Date:6/13/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a ... Food and Drug Administration (FDA) has notified the Company that ... Zhejiang, China manufacturing facility has been ... clearance of the Warning Letter related to our ... of the progress we have made in our ongoing quality ...
(Date:6/10/2017)... , June 9, 2017  Shane K. Burchfield, DPM, is recognized ... excellence as a Podiatrist in Alabama . ... Family First Foot Care. He brings over 20 years of experience, ... management and healthcare, to his role. ... Care, PC is pleased to welcome you to his ...
Breaking Medicine Technology:
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and ... has selected 21 leaders from government, business and civil society in 11 countries across ... U.S. this fall, engaging in a transformative exchange of knowledge and ideas with the ...
(Date:6/23/2017)... Santa Monica, CA (PRWEB) , ... June 23, 2017 , ... ... PureLife as the endorsed amalgam separator supplier for CDA members. As part of the ... a reduced price of $99, saving more than $400 off the retail value. This ...
(Date:6/23/2017)... Jupiter, FL (PRWEB) , ... June 23, 2017 , ... ... the award winning series, which is slated to air fourth quarter 2017. American Farmer ... Christian D.A. Hansen, a Danish pharmacist, founded Chr. Hansen in Denmark in 1874 ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... management, financial planning, and related services to families and business owners in and ... charity drive to benefit senior citizens in the area. , Meals on Wheels ...
(Date:6/23/2017)... ... 2017 , ... All-Star Insurance, a family managed agency that offers insurance management ... announcing the launch of a new charity drive to benefit women in the area ... reveal that an estimated 252, 710 new cases of invasive or high risk breast ...
Breaking Medicine News(10 mins):