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ViroPharma and Halozyme Announce Collaboration for Combination of Recombinant Human Hyaluronidase Enzyme (rHuPH20) Technology with C1 Esterase Inhibitor
Date:5/11/2011

resent a barrier to entry for potential competitors looking to utilize these hyaluronidases.

"This collaboration is consistent with our goals of continually providing innovative product enhancements, advancing long-term solutions to meet the needs of our patients, and helping to maintain and build Cinryze brand loyalty for years to come," commented Colin Broom, M.D., ViroPharma's chief scientific officer. "The goal of our broad subcutaneous Cinryze program is to enable more patients with hereditary angioedema to benefit from access to convenient formulations of Cinryze to prevent their HAE attacks."

"We believe our rHuPH20 technology can optimize the Cinryze experience by providing an improved subcutaneous formulation of the therapy," commented Gregory I. Frost, Ph.D., Halozyme's president and chief executive officer.  "We look forward to working with ViroPharma to simplify administration of this important biologic and, ultimately, provide a more convenient therapy to as many people as possible with HAE worldwide."

Cinryze is the first and only U.S. FDA-approved C1 esterase inhibitor therapy indicated for routine prophylaxis against angioedema attacks in adolescent and adult patients with hereditary angioedema, a rare, debilitating and potentially fatal disease. Cinryze is currently approved for intravenous administration.

ViroPharma / Halozyme Collaboration in Hereditary Angioedema

Halozyme has granted ViroPharma an exclusive worldwide license to use Halozyme's proprietary Enhanze technology in combination with C1 esterase inhibitor. The initial focus of the collaboration will be on the development of a novel subcutaneous formulation of Cinryze for routine prophylaxis against attacks of HAE.

Under the terms of the license agreement, ViroPharma will provide Halozyme an initial upfront payment of $9 million, and another $3 million on initiation of the first Phase 2 study, anticipated to begin later this yea
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SOURCE ViroPharma Incorporated
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