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ViroPharma Announces Publication of Cinryze™ (C1 Esterase Inhibitor [Human]) Phase 3 Trial Results in Hereditary Angioedema (HAE) in the New England Journal of Medicine
Date:8/5/2010

EXTON, Pa., Aug. 5 /PRNewswire-FirstCall/ -- ViroPharma Incorporated (Nasdaq: VPHM) today announced that data from Phase 3 studies of Cinryze™ (C1 esterase inhibitor [human]) have been published in the August 5, 2010 issue of the New England Journal of Medicine.  The paper entitled Nanofiltered C1 Inhibitor Concentrate for Treatment of Hereditary Angioedema by Dr. Bruce L. Zuraw et al. describes the safety and efficacy of Cinryze in treating and preventing attacks of hereditary angioedema. Cinryze is the first and only FDA-approved C1 esterase inhibitor therapy indicated for routine prophylaxis against angioedema attacks in adolescent and adult patients with hereditary angioedema (HAE), a rare, debilitating and potentially fatal disease; it is not approved by the FDA to treat acute angioedema attacks.  

According to the publication, when used for prophylaxis, Cinryze significantly reduced the frequency of hereditary angioedema attacks (p<0.001), in addition to reducing the severity and duration of attacks, the need for open-label rescue therapy and the total number of days of swelling compared to patients receiving placebo.  Patients administered Cinryze for acute angioedema attacks experienced a significant reduction in the time to unequivocal relief of symptoms versus those receiving placebo (p=0.02).  

In addition, the authors stated that the incorporation of nanofiltration along with pasteurization in the Cinryze preparation provides an additional level of safety that may be particularly important for protecting against non-enveloped viruses and new infectious agents such as prio
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SOURCE ViroPharma Incorporated
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