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ViroPharma Announces Presentation of Cinryze(TM) Data in Acute Treatment of Hereditary Angioedema
Date:11/12/2008

lso reported visiting an average of 4.4 different physicians before receiving an accurate diagnosis of HAE. In addition, survey participants had an average of two immediate and two extended family members that had been diagnosed with HAE, but only 48 percent of their immediate family members and 26 percent of their extended family members had been tested for HAE.

"Accurate, timely diagnosis of HAE patients continues to be a challenge, and despite the fact that HAE is a hereditary disorder, testing family members is not common practice; a consensus statement may lead to improved and earlier diagnosis of patients with HAE," said Timothy Craig, DO, professor of medicine, Penn State University, who co-presented the survey data. "These findings indicate that testing family members for HAE should be a primary concern for those caring for patients with the disorder, and patients should be alerted to the need for screening of their family members."

About Cinryze C1 Inhibitor (human)

Cinryze is a highly purified, pasteurized and nanofiltered plasma-derived C1 inhibitor product that has been approved by FDA for routine prophylaxis against angioedema attacks in adolescent and adult patients with HAE. C1 inhibitor therapy has been used acutely for more than 30 years in Europe to treat patients with C1 inhibitor deficiency. Cinryze has not been approved for acute treatment in the United States or any other jurisdiction.

Cinryze has been well tolerated. The most common adverse reactions observed have been upper respiratory infection, sinusitis, rash and headache. No drug-related serious adverse events (SAEs) have been observed in clinical trials. Severe hypersensitivity reactions may occur. Thrombotic events have occurred in patients receiving high dose off-label C1 inhibitor therapy well above the approved treatment dosage regimen. With any blood or plasma derived product, there may be a risk of transmission of infectious agents, e.g. viruses and, the
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SOURCE ViroPharma Incorporated
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