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ViroDefense Inc Announces Selection of Poliovirus Antiviral Preclinical Candidate
Date:6/3/2008

upport ViroDefense in its efforts to address a clear public health need during both the final stages of the polio eradication effort and in the post-eradication era," said Thomas P. Koestler, Ph.D., President of Schering-Plough Research Institute.

Background

The Global Polio Eradication Initiative, launched by the World Health Organization (WHO) in 1988, is approaching its goal and expects to certify the world free of polio in the near future. Protecting the estimated $7 billion, two-decade investment will depend on the policies, defense strategies and emergency response capabilities available during these final stages of eradication and in the post-eradication era. These safeguards must protect against virus re-introduction, and in the event of re-introduction, must rapidly contain, control and eliminate the virus.

In November 2005, the National Research Council (NRC) held a workshop, at the request of the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC), to discuss the role and utility of a polio antiviral drug in the efforts to eradicate poliovirus and in the defense of a polio-free world post-eradication. It was concluded that a polio antiviral drug, used alone or in conjunction with current vaccines, would be useful in the control of polio outbreaks, providing increased response flexibility and improved effectiveness. It was further recommended that drug development begin immediately. Currently, there are no drugs for treatment or prevention of poliovirus disease.

In October 2006, the Task Force for Child Survival and Development proposed that a Poliovirus Antiviral Initiative be established to implement the NRC recommendations. The Advisory Committee on Poliomyelitis Eradication (ACPE) supported the proposal and recommended action. In June 2007, the CDC acted on the ACPE recommendations by contracting the Task Force to facilitate development of effective polio antiviral drugs for global public hea
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SOURCE ViroDefense Inc
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