Navigation Links
ViroDefense Inc Announces Selection of Poliovirus Antiviral Preclinical Candidate
Date:6/3/2008

Compound Emerged from Technology Licensed from Schering-Plough Research

Institute

ROCKVILLE, Md., June 3 /PRNewswire-FirstCall/ -- ViroDefense Inc today announced that it has chosen to advance a compound licensed to ViroDefense Inc by Schering-Plough Corporation into IND-enabling preclinical studies for the prevention and treatment of poliovirus infections.

Schering-Plough licensed to ViroDefense Inc the exclusive rights for development of a specific compound series for polio indications. The license was provided in exchange for the purchase of compound testing supplies and potential future royalties on sales. Schering-Plough Research Institute had been developing the series for treatment of diseases caused by non-polio enteroviruses, such as the coxsackie viruses. ViroDefense Inc determined in laboratory tests that compounds of the series had promising anti-poliovirus activity.

The licensed compounds belong to the antiviral mechanistic class termed "capsid inhibitors." Compounds of this class inhibit the function of the poliovirus capsid, the outer protein coat of the virus, by integrating into the capsid at a specific site or pocket. By doing so, they prevent virus "uncoating" and the release of the viral RNA from the capsid, thereby blocking the initiation of the viral infection cycle.

The lead anti-poliovirus compound, V-073, has been shown to have potent and broad-spectrum anti-poliovirus specific activity, favorable pharmacologic and pharmacokinetic attributes, and the safety and tolerability profile suitable for its advancement as a preclinical candidate. Consequently, IND- enabling studies will commence with V-073.

"We are grateful to Schering-Plough for their willingness to offer this promising antiviral series for the fight against polio," commented Marc S. Collett, President of ViroDefense Inc. "This is clearly a humanitarian gesture on their part."

"We are very pleased to s
'/>"/>

SOURCE ViroDefense Inc
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. BioElectronics Announces Profitability Breakeven and Additional Clinical Trials
2. Anesiva Announces South Korea FDA Approval of Adlea(TM) Investigational New Drug Application
3. Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytrens Contracture
4. Trubion Announces Presentation of Positive TRU-016 Data at ASCO
5. Alliance Pharmaceutical Corp. Announces Approval of Proposed Actions at Annual Shareholders Meeting
6. Vion Pharmaceuticals Announces Presentation of Interim Data from Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Acute Myelogenous Leukemia at the ASCO(R) Annual Meeting
7. Medivation Announces Presentation of Positive MDV3100 Clinical Data in Castration-Resistant Prostate Cancer Patients at 44th ASCO Annual Meeting
8. Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois
9. IDM Pharma Announces Phase 2 Follow-Up Data Showing IDM-2101 is Well Tolerated With Positive Survival Trend in Non-Small Cell Lung Cancer Patients
10. Nektar Announces Expanded Phase 2 Clinical Development Plan For NKTR-102 (PEG-irinotecan)
11. CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... ATLANTA , May 1, 2015 At ... May 2-6 in Washington D.C. , ... a solution that enables clinicians to leverage the enormous ... Knife radiosurgery treatments conducted each year – to advance ... "Gamma Knife Registry is a cloud-based solution that allows ...
(Date:5/1/2015)... 2015 Braeburn Pharmaceuticals announced today ... focus beyond addiction and pain to include ... has acquired an implantable, six-month formulation of ... treatment of schizophrenia from Endo Pharmaceuticals. With ... to other potential applications of the implant ...
(Date:5/1/2015)... , May 1, 2015  Legendary actor and ... in a new PBAFacts campaign designed to educate and ... learn more about Pseudobulbar Affect (PBA) and to speak ... that an actor has the ability to cry and ... lack of control experienced by people living with PBA ...
Breaking Medicine Technology:Elekta to showcase Leksell Gamma Knife Registry at AANS Annual Meeting 2Elekta to showcase Leksell Gamma Knife Registry at AANS Annual Meeting 3Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 2Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 3Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 4Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 2Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 3
... Sheets: MDBX ) ( www.thedispensingsolution.com ) announced today ... secure medicine storage and retrieval system. This ... their filled prescriptions from a convenient self-serve system that could ... process is as simple as it is ingenious: When a ...
... WASHINGTON, Nov. 16, 2011 The Personalized Medicine ... its landmark report, The Case for Personalized ... commercially available personalized medicine products from 13 in ... the continued development and adoption of personalized medicine ...
Cached Medicine Technology:MedBox Develops Patent-Pending System for Storage and Retrieval of Prescription Drugs 272 Prominent Personalized Medicine Products Available; A Five-Fold Increase in Five Years 2
(Date:5/2/2015)... It’s a pattern that won’t relent anytime ... on this planet, cyber scammers will immediately be thinking ... their own personal gain. And on April 30, ... issued an alert titled “Nepal Earthquake Disaster Email Scams,” ... earthquake in Nepal. The scam emails may contain links ...
(Date:5/2/2015)... 2015 Kare Visits LLC. launched in Chicago ... caregivers. Kare Visits offers relief for caregivers by visiting ... According to the Caregiver Action Network, eight in ... 20 hours a week caring for an elderly or disabled ... hire a nurse, a caregiver is now empowered to schedule ...
(Date:5/1/2015)... IDLife LLC, a health and wellness ... the addition of its newest partner and fitness celebrity, ... athlete, growing up in gymnastics and competitive diving, but ... a personal trainer and helping others achieve their fitness ... TV shows highlighting her stunning physique and unique training ...
(Date:5/1/2015)... ME (PRWEB) May 01, 2015 Royal ... in Freeport, Maine, reports on a new study that ... stiffness, joint swelling and improved physical function as well ... with severe osteoarthritis of the knee. , The report ... Natural Insights for Well Being® ,” which Royal River ...
(Date:5/1/2015)... May 01, 2015 Hope For The ... of Hope For The Warriors® and military families. All ... support Hope For The Warriors®, a national nonprofit dedicated ... unit, and restoring hope for our service members and ... All American Ford collected and matched small autograph fee ...
Breaking Medicine News(10 mins):Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:IDLife LLC Announces New Partnership with Fitness Celebrity, Jen Widerstrom 2Health News:New Study Finds Nutrients Ease Arthritis Pain, Retailer Reports 2Health News:All American Ford Presents Donation to Nonprofit Hope For The Warriors 2
... Children,s Hospital in Houston announces that a researcher in ... Science Foundation Early Career Development (CAREER) Award for his ... heart defects, and the development of tissue engineering therapies ... award comes with new funding of $450,000 to be ...
... brain function variations between the left and right sides ... weight of the placenta. The finding could shed new ... later life. The research, conducted at the University ... Epidemiology Unit at Southampton General Hospital, reveals that children ...
... This release is available in Spanish . ... arising because the patient inherits from the father or mother a mutation ... BRCA2 have already been identified as two of the genes to be ... are due to mutations in one of these two genes (which suggests, ...
... the Basque Country (UPV/EHU) has carried out the first ... and generations in terms of forgiveness. According to the ... better at forgiving than men. "This study has ... what reasons people have for forgiving men and women, ...
... with both type 1 diabetes and CKD have an ... patients with type 1 diabetes and overt nephropathy develop ... death. The competing risks of death and ESRD may ... Now, the researchers at the University of Helsinki, ...
... HealthDay Reporter , THURSDAY, Feb. 17 (HealthDay News) ... separated from street traffic have fewer accidents compared to ... "We found that there is a 28 percent ... with bicycling in parallel and comparable roads," noted study ...
Cached Medicine News:Health News:Tissue engineering methods earn funding to heal little hearts 2Health News:Brain function linked to birth size in groundbreaking new study 2Health News:Ph.D. thesis on 2 genes involved in hereditary breast and ovary cancer cases 2Health News:Women are better at forgiving 2Health News:Competing risks analysis highlights new targets in preventing ESRD and death of diabetics 2Health News:Separate Bikes-Only Lanes in Cities Cut Injury Rate: Study 2Health News:Separate Bikes-Only Lanes in Cities Cut Injury Rate: Study 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: