Navigation Links
Vion Pharmaceuticals Announces Initiation of Clinical Trial of Cloretazine(R) (VNP40101M) in Combination with Cytarabine
Date:5/8/2008

NEW HAVEN, Conn., May 8 /PRNewswire-FirstCall/ -- VION PHARMACEUTICALS, INC. (Nasdaq: VION) today announced the start of an investigator-sponsored Phase I/II clinical trial of its lead anticancer agent Cloretazine(R) (VNP40101M) in combination with cytarabine in elderly patients with previously untreated acute myelogenous leukemia (AML) and high-risk myelodysplastic syndromes (MDS). The trial is being conducted under the direction of Ellen K. Ritchie, M.D. at The Weill-Cornell Medical College in New York City. Co- investigators for the study are Eric Feldman, M.D. and Gail Roboz, M.D.

The objectives of the trial are: (i) to define the maximum tolerated dose (MTD) of Cloretazine(R) (VNP40101M) when given in combination with cytarabine to AML and high-risk MDS patients over the age of 60, and (ii) to evaluate this combination further for safety and efficacy in a larger cohort of patients. Cloretazine(R) (VNP40101M) will be given as a 30 - 60 minute infusion on day 1 approximately 3-4 hours after the start of the cytarabine infusion. Cytarabine will be administered as a continuous infusion of 100 mg/m2/day for 7 days. In the Phase I portion of the study, dose escalation will be done in cohorts of at least 3 patients and the maximum tolerated dose (MTD) identified in the Phase I segment will be used in the Phase II segment of the study.

Ann Cahill, Vice President, Clinical Development, commented, "It is important for us to continue to study Cloretazine(R) (VNP40101M) in combination with different doses and schedules of cytarabine, the most widely used drug in the treatment of AML. In addition, we want to evaluate Cloretazine(R) (VNP40101M) in a broader group of elderly patients than are currently being studied in our pivotal tri
'/>"/>

SOURCE Vion Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Arena Pharmaceuticals, Inc. Announces Initiation of Phase 1 Clinical Trial of Drug Candidate Under Partnership with Taisho Pharmaceutical Co., Ltd.
2. Poniard Pharmaceuticals Completes Enrollment of Phase 2 Picoplatin Trial in Colorectal Cancer
3. Cadence Pharmaceuticals Reports First Quarter 2008 Financial Results and Provides Clinical Program Update
4. Alseres Pharmaceuticals Enters Agreement to Amend Cethrin(R) License to Lower Milestone Payments and Royalty Rates
5. Champions Biotechnology and Concordia Pharmaceuticals Complete Service Agreement and Begin Preclinical Evaluation of Oncology Drugs
6. Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity
7. Roche Exercises its Option to Further Develop and Commercialize Memory Pharmaceuticals Nicotinic Alpha-7 Agonist, MEM 3454
8. Alexza Pharmaceuticals to Present AZ-004 Phase 2a Clinical Data at the American Psychiatric Association Annual Meeting
9. ISTA Pharmaceuticals Announces New Phase III Clinical Findings to Support Bepreve NDA Filing
10. Cequent Pharmaceuticals Johannes Fruehauf, MD, Ph.D., to be Featured Speaker at RNAi World Congress in Boston - May 2, 2008
11. Idenix Pharmaceuticals Reports First Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 2015 Research and Markets ( ... "The Corporate Reputation of Pharma - The ... report to their offering. The ... now in its fourth edition. This report contains ... For each annual Corporate Reputation report, the author ...
(Date:4/16/2015)... , April 16, 2015 Vanda Pharmaceuticals Inc. ... on the development and commercialization of products for the ... will release results for the first quarter of 2015 ... The Company will host a conference ... 2015, during which Vanda management will discuss the first ...
(Date:4/16/2015)... 2015  Amgen (NASDAQ: AMGN ) today announced ... on Tuesday, April 21, 2015, after the close of ... by a conference call with the investment community at ... will be Robert A. Bradway , chairman and ... management team. Live audio of the conference ...
Breaking Medicine Technology:The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2Vanda Pharmaceuticals to Announce First Quarter 2015 Financial Results on May 6, 2015 2Amgen Announces Webcast Of 2015 First Quarter Financial Results 2
... SCOTTSDALE, Ariz., Feb. 14, 2012  Cayenne Medical, Inc., a ... of a $10 million equity financing, with new investor ... MB Venture Partners and Investor Growth Capital. The proceeds ... distribution and to support expansion of its portfolio of ...
... 2012 Leading events organiser UBM Live , a ... of Jim Buckley as the new Brand Director for Informex. ... value chemistry via a comprehensive calendar of conferences and events, ... is run in partnership with the Society of Chemical Manufacturers ...
Cached Medicine Technology:Cayenne Medical Closes $10 Million Capital Raise 2UBM Live Appoints Jim Buckley as Informex Brand Director 2UBM Live Appoints Jim Buckley as Informex Brand Director 3
(Date:4/19/2015)... Carinsurancesavings.biz has released a new blog post explaining ... who have diabetes. , Clients who have diabetes ... newly released blog post explains how diabetes influences auto ... low cost coverage. , It is now possible ... single website. Clients can visit http://carinsurancesavings.biz for ...
(Date:4/19/2015)... New York (PRWEB) April 19, 2015 ... on Multidistrict Litigation (JPML) indicate that Lipitor lawsuits ( ... underway in U.S. District Court, District of South Carolina. ... new cases have been filed in the proceeding on ... due to their use of the cholesterol-lowering statin. This ...
(Date:4/19/2015)... A live auction will be held to sell over ... Brooklyn, NY and other national consignors. Various types of equipment ... and much more. , The auction will take place ... CDT each day. The equipment is at their Chicago warehouse ... Anyone can participate in the auction including those who ...
(Date:4/19/2015)... 2015 Indiana Fiber Network, LLC ... announces a major bandwidth upgrade infrastructure service to ... Craigville Telephone Company, Inc. (DBA AdamsWells), one ... IFN’s protected 10 Gigabit internet transport ring. ... of Sales and Marketing, AdamsWells expanded Internet bandwidth ...
(Date:4/19/2015)... Dells, WI (PRWEB) April 19, 2015 ... designer announces that it will exhibit it’s pioneering ... and Expo and the Iowa-Illinois Safety Council Professional Development ... 6350 and the TaskMate EZ are used in volume ... healthcare facilities. , Built to clamp to a ...
Breaking Medicine News(10 mins):Health News:Finding Low Cost Auto Insurance for Diabetic Drivers! 2Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 2Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 3Health News:Centurion to Sell Surplus Medical Equipment in Online and On-Site Auction 2Health News:AdamsWells Internet Telecom TV Expands Bandwidth via Indiana Fiber Network, LLC 2Health News:HealthPostures' TaskMate Products to be Exhibited at the Wisconsin and Iowa-Illinois Safety Conferences 2
... jolly well does it , , MONDAY, Dec. 24 (HealthDay News) ... millions of chimneys, bulging sacks in tow -- how ... everywhere south of the North Pole have pondered that question ... at the Santa Institute, a special think-tank based at the ...
... 24 Veterans Affairs Medical,Center is about to draw ... spiraling cost of healthcare nationwide., The local VA ... a privacy,curtain for hospital beds that is literally a ... hospital bed curtains. The,innovation called Simply 66 could save ...
... appears to play a central role in the success of ... disease and other brain disorders. The surprising finding is outlined ... , The work shows that adenosine, a brain chemical most ... the effect of deep brain stimulation, or DBS. The technique ...
... (Nasdaq: ARAY ), a global leader in the ... for its second quarter fiscal,year 2008, ending December 29, ... A conference call to review the results will ... be hosted by Euan S. Thomson, Ph.D., president and,chief ...
... Serve Your Champagne This Holiday With Style And ... Ease - And Most Importantly No Injuries, ... that brings a little sparkle to your holiday get together,with ... more than 900 million glasses of champagne this year, over ...
... , , FRIDAY, Dec. 21 (HealthDay News) -- Screening tests ... low-income U.S. women cost about $150 annually per woman ... total cost per woman each year, including administrative, quality ... the analysis of the National Breast and Cervical Cancer ...
Cached Medicine News:Health News:Scientists Marvel at Santa's Stamina 2Health News:Scientists Marvel at Santa's Stamina 3Health News:VA Hospital Draws Curtain on Innovation That Could Help Reduce Spiraling Cost of Hospital Maintenance Nationwide 2Health News:Sleep chemical central to effectiveness of deep brain stimulation 2Health News:Sleep chemical central to effectiveness of deep brain stimulation 3Health News:Accuray Incorporated to Report Second Quarter Fiscal Year 2008 Financial Results 2Health News:Accuray Incorporated to Report Second Quarter Fiscal Year 2008 Financial Results 3Health News:Five Steps to Pop the Cork - Not Your Eye Out 2Health News:Five Steps to Pop the Cork - Not Your Eye Out 3Health News:Low-Income Women's Cancer Screenings Cost Effective: Report 2Health News:Low-Income Women's Cancer Screenings Cost Effective: Report 3
... drainage from the ureteropelvic junction to the ... segment with no sideports prevents postoperative narrowing ... of the ureteral wall to the stent. ... one-time use. CAUTION: Periodic evaluation is advised; ...
... Whether you prefer silicone or ... Specialty Stents help promote healing after ... guards against anastomotic stricture, supports the ... the prevention of postoperative leakage. Following ...
... The Max-Blade™ Coagulating Resector is a device that ... This patented design was developed to provide the ... same high quality pathology chip, the approximate speed ... enjoyed with a standard loop but with ...
... Used for stone manipulation and removal in ... the basket to retain its shape following extreme ... stone capture by allowing the basket to open ... the stone. The tipless design reduces the likelihood ...
Medicine Products: