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VioQuest Pharmaceuticals Completes Enrollment of Phase I Trial of Lenocta(TM)
Date:10/10/2007

Company Intends to Commence Follow-on Phase IIa Trial

Increase in Dendritic, Natural Killer, and T-cell Activity Observed

BASKING RIDGE, N.J., Oct. 10 /PRNewswire-FirstCall/ -- VioQuest Pharmaceuticals (OTC Bulletin Board: VQPH), a New Jersey-based biopharmaceutical company focused on acquiring, developing and commercializing targeted cancer therapeutics, announced today that it has completed enrollment in its Phase I open-label dose escalation trial of its investigational drug, Lenocta(TM), (sodium stibogluconate) for the treatment of solid tumors. Lenocta(TM) is a potent and selective inhibitor of SHP-1 and SHP-2. Inhibition of these key regulatory enzymes results in the up-regulation of the response to immunologic stimuli (cytokines) and inhibition of mitogenesis. In addition to reaching the maximum tolerated dose (MTD), dose dependent activities were observed in protocol-specified surrogate biomarkers in both cellular and humoral immunologic functions. VioQuest intends to begin enrolling patients in a follow-on Phase IIa.

(Logo: http://www.newscom.com/cgi-bin/prnh/20070117/NYW085LOGO)

A total of 17 patients were enrolled in the Phase I study. Asymptomatic hypokalemia was the only dose limiting toxicity (DLT) observed. Analysis of the data showed an increase in pharmacodynamic activities as demonstrated by increase in the activities of natural killer, CD8 and type II dendritic cells.

Edward C. Bradley, M.D., VioQuest's Chief Scientific Officer, stated, "The increased function in T, NK, and dendritic cell populations at a dose that is well tolerated is exactly what we had hoped to see in this Phase I trial, and we look forward to the Phase IIa program which is now ready to enroll patients."

About Lenocta(TM)

Lenocta(TM) is an inhibitor of multiple protein tyrosine phosphatases (PTPases), specifically the SRC homology PTPase (
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SOURCE VioQuest Pharmaceuticals
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