Navigation Links
ViiV Healthcare Presents Positive Data from Phase IIIb/IV Study of Dolutegravir vs Darunavir in Treatment-Naive Adults with HIV-1
Date:9/12/2013

DENVER, Sept. 12, 2013 /PRNewswire/ -- ViiV Healthcare today announced initial results from the Phase IIIb/IV FLAMINGO (ING114915) study. This open-label study, for the first time, compared once-daily regimens containing 50mg dolutegravir with once-daily regimens containing a protease inhibitor (PI) (800mg darunavir boosted with 100mg ritonavir) in treatment-naive adults with HIV-1. Both treatment arms were administered with investigator-selected dual NRTIs. Non-inferiority was demonstrated at the 48-week time point between the dolutegravir and darunavir-based regimens. A subsequent, pre-specified testing procedure demonstrated statistical superiority in the dolutegravir treatment arm.

At 48 weeks, a significantly greater proportion of the patients treated with the dolutegravir regimen (90%) were virologically suppressed (HIV-1 RNA <50 copies/mL, the primary endpoint of the study per FDA snapshot) compared to those treated with the darunavir regimen (83%, adjusted treatment difference [95% CI] 7.1% (0.9%, 13.2%); P=0.025; N=242 in each arm). Comparing the dolutegravir and darunavir arms, rates of virologic non-response were 6% versus 7%, rates of treatment withdrawal due to adverse events were 1% versus 4%, and rates of treatment withdrawal for other reasons (such as protocol deviation, lost to follow-up or consent withdrawn) were 2% versus 5%. There were no treatment-emergent primary viral mutations leading to treatment resistance in either study arm. These data were presented at the 53rd International Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Denver, Colorado.1 

"These new clinical data are an important addition to our scientific understanding of dolutegravir," said Dr John Pottage, Chief Medical Officer, ViiV Healthcare. "This is the first study in our clinical programme to compare dolutegravir to a boosted protease
'/>"/>

SOURCE ViiV Healthcare
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Clinical Trial at Evergreen Healthcare Shows Intestinal Gel Reduces Symptoms of Advanced Parkinsons Disease
2. Netsmarts Focus on Innovation to Help Health and Human Service Providers Span the Spectrum of Care in the Healthcare 3.0 Environment
3. Qmed, the Leading Global MedTech Industry Resource, Partners with Clarimed, to Provide the Medical Manufacturing and Healthcare Industry with FDA Reports on Adverse Events
4. Attendees Save Up To $800 on Global Healthcare Conferences in 2012 by Registering Through Global Information Inc.
5. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
6. Nearly 300 Medical Device, Healthcare Professionals Attend First National Conference on Value-driven Engineering
7. Varian Medical Systems and Siemens Healthcare Announce Global Collaboration to Advance Clinical Capabilities and Offerings in Radiotherapy and Radiosurgery
8. Med Ad News Honors Healthcare Communication Agencies at 23rd Annual Manny Awards
9. Quest Diagnostics Establishes Unique Healthcare Identifier to Improve Access to Vital Patient Health Information; 80 Million Patient IDs Created to Date
10. Evergreen Healthcare Foundation Gala Raises Nearly $1.1 Million to Benefit Breast Health Center
11. Bayer Employees Named Rising Stars by Healthcare Businesswomens Association
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 2014  Decision Resources Group finds that while ... specialists are willing to prescribe Durata,s Dalvance (dalbavancin) ... as OPAT, approximately two-thirds of the respondents reported ... hospital inpatients. However, our findings indicate that nearly ... on OPAT following hospital discharge, and most are ...
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds ... its store . (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ... upgrade and policy support, China,s ... years, with total market size rising from 3.28 billion ...
(Date:1/15/2014)... Jan. 15, 2014  Novation, the leading health care supply ... IT value-added reseller (VAR) national contracts that expand its ... services at lower costs. These include manufacturer product and ... initiative assistance and ongoing IT consulting support. ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2
... April 9, 2008 Dutch biotechnology,company Crucell N.V., ... South,African Tuberculosis Vaccine Initiative (SATVI) present a progress ... tuberculosis vaccine study at the,biennial "Tuberculosis Vaccines for ... today. The study, conducted in Worcester, South,Africa and ...
... NEW YORK, April 9, 2008 Intra-Cellular ... its ongoing development,programs for ITI-007, the Company,s ... (DPPM), and ITI-722,a low-dose formulation of ITI-007, ... disorders, respectively. These new data demonstrate,ITI-007 has ...
Cached Medicine Technology:Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 2Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 3Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 4Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 5Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 6Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722 2Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722 3
(Date:7/11/2014)... Even the hot Texas sun won’t keep ... . The school had previously invested in a ... from APCPLAY, but recently asked for an innovative solution to ... Godley Elementary School chose a Rectangular Shade from APCPLAY as ... on their playground. The shade measures 24’W x 34’H ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Based in ... care to residents of Brazoria County and surrounding counties. ... the clinic is now accessible from Northbound Highway 288 ... a center where patients can get low-cost urgent care ... far from rare, finding places that can match the ...
(Date:7/10/2014)... 2014 Fatigue, lack of safety ... number of accidents in the workplace, according to ... articles highlight safety issues that contribute to the ... occur on the job annually, according to the ... explore "preventable workplace accidents." , Safety Issue: "Extended ...
(Date:7/10/2014)... 2014 According to a new ... Platforms (Land, Airborne, Naval), Application (Software Defined Radios, ... Geography (North America, Asia-Pacific, Europe, the Middle East ... by MarketsandMarkets, the market is estimated to be ... register a CAGR of 5.56% to reach $39.52 ...
(Date:7/10/2014)... 2014 Parker Waichman LLP, a ... of victims injured by defective medical devices, reports ... allegations that the woman’s hidden, aggressive leiomyosarcoma was ... used during a routine laparoscopic supracervical hysterectomy procedure. ... Medical Instruments Corporation over its Wolf Power Morcellator ...
Breaking Medicine News(10 mins):Health News:Cool Fun Under the Texas Sun: Godley Elementary School Purchases Shade Structure from APCPLAY© 2Health News:Prime Urgent Care Announces New Access to the Clinic, Available from Northbound Highway 288 2Health News:Safety Reboot Magazine Focuses on: Why Extended Hours is Dangerous in the Workplace; Why Custodial Work Can be Dangerous; and Improving Safety for Roofers 2Health News:Safety Reboot Magazine Focuses on: Why Extended Hours is Dangerous in the Workplace; Why Custodial Work Can be Dangerous; and Improving Safety for Roofers 3Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 2Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 3Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 4Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 5
... , This release is available in Spanish ... have a powerful effect on formation of strong, healthy bones, ... hold true for humans. Jin-Ran Chen and his ... U.S. Department of Agriculture (USDA) at the Arkansas Children,s Nutrition ...
... tsunamis to war and genocide which wreak devastation on millions ... from the headlines. But how do policymakers, charities and medics ... influences their tactics and the style of humanitarian aid? ... London School of Hygiene & Tropical Medicine, with Boris Martin, ...
... In the 1983 movie "A Man with Two Brains," Steve Martin ... two brains inside his own skull as we all do, ... it comes to seeing the world around us, each of our ... working memory. Normally, it takes years or decades after a ...
... By Steven Reinberg HealthDay Reporter , MONDAY, ... increasingly popular, inflatable models, pose serious risks to young children, ... Children,s Hospital in Columbus, Ohio, detail the drowning deaths of ... a variety of above-ground pools, some large and deep, others ...
... substitutes used in low-calorie potato chips and other foods ... according to a study published by the American Psychological ... challenges the conventional wisdom that foods made with fat ... fat substitutes can interfere with the body,s ability to ...
... of medicine and community health sciences at Boston University ... Institute on Drug Abuse (NIDA) International Program 2011 Awards ... and investment in mentoring scientists in their pursuits in ... who is also chief of the Section of General ...
Cached Medicine News:Health News:Blueberries help lab rats build strong bones 2Health News:New book shines light on French versus British models of humanitarian aid 2Health News:Picower: 1 skull + 2 brains = 4 objects in mind 2Health News:Picower: 1 skull + 2 brains = 4 objects in mind 3Health News:Portable Pools Pose Drowning Risk for Young Kids 2Health News:Portable Pools Pose Drowning Risk for Young Kids 3Health News:Fat substitutes linked to weight gain 2Health News:BU'S Jeffrey H. Samet, M.D., selected as a 2011 NIDA International Program Awards of Excellence winner 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: