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Video: UCB Launches Vimpat(R) in the U.S. for Add-On Treatment of Epilepsy in Adults
Date:5/26/2009

200 and 400 mg/day experienced a median percent reduction in seizure frequency per 28 days of 33.3% and 36.8%, respectively, versus only 18.4% reduction in the placebo group. Additionally, 34.1% and 39.7% of patients taking Vimpat at 200 and 400 mg/day, respectively, experienced greater than or equal to 50% reduction in seizure frequency versus only 22.6% in the placebo group.

Patients randomized to Vimpat(R) also experienced improvement in seizure freedom rates, compared with placebo. Across the pivotal trials, 3.3% of patients randomized to 400 mg/day of Vimpat(R) were seizure free throughout the 12-week maintenance phase, vs. 0.9% of placebo patients. Seizure free days increased by 8% with 200 mg/day of Vimpat(R) and by 12% with 400 mg/day of Vimpat(R), compared with 6% for placebo.

Patients began experiencing a reduction in seizures during the titration phase and maintained or had improved seizure control throughout the studies. The most common adverse events (>10 percent in the Vimpat(R)-treated group and greater than placebo) reported in these trials included dizziness, headache, nausea, and diplopia. More than half of the patients completing the clinical trials opted to continue treatment, some for longer than five years.

Vimpat(R) demonstrated efficacy and tolerability when combined with a broad range of existing AEDs, and also provided efficacy regardless of the number of concomitant AEDs. Vimpat was also studied with several commonly used medications, including digoxin, metformin, omeprazole, and an oral contraceptive (containing 0.03 mg ethinylestradiol and 0.15 mg levonorgetstrel).

Vimpat(R) dosing should start at 50 mg twice daily and may be increased to a daily dose of 200 to 400 mg per day (recommended therapeutic dosing) administered in two divided doses. Vimpat(R) is available as oral tablets and as an intravenous (IV) infusion to allow for consistent treatment in an emergency r
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