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Video: UCB Launches Vimpat(R) in the U.S. for Add-On Treatment of Epilepsy in Adults
Date:5/26/2009

a single drug:

  • In a study of 525 people with epilepsy, less than half (47%) attained seizure control with the first AED
  • More than 30% of patients will continue to experience seizures despite trying two or more AEDs

"Vimpat(R) has a novel mechanism of action, and has been studied in combination with multiple AEDs as well as several commonly used medications with no clinically significant pharmacokinetic drug interactions observed in clinical trials. This demonstrates the importance and potential utility of including Vimpat(R) in partial onset epilepsy treatment regimens," said Kathleen Bos, MD, vice-president, medical affairs, U.S., UCB.

While treatment with one drug remains the goal of AED therapy and provides adequate control to many patients, almost 40% of patients with epilepsy receive suboptimal seizure control on monotherapy. In these situations, a physician may prescribe different treatments until one is found to provide adequate seizure control for the patient.

However, some studies indicate that when primary therapy is well-tolerated, but does not provide adequate seizure control, adding an additional AED to the current one provides more seizure control than continually switching therapies.

Vimpat(R) approval based on clinical trials with approximately 1,300 patients

The approval of Vimpat(R) is based on efficacy and safety data from one Phase II and two Phase III clinical trials with approximately 1,300 adults with epilepsy who had uncontrolled partial-onset seizures. Before adding Vimpat(R), patients experienced a median baseline seizure frequency ranging from 10 to 17 seizures per month, despite being on one to three other AEDs; and 45.2 percent of patients had previously tried seven or more AEDs to control their seizures.

In the studies, patients taking Vimpat at
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SOURCE UCB
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