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Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test
Date:5/1/2008

he IL1B gene is among the first gene activated when the body encounters a challenge of almost any type, ranging from bacterial infections to bad cholesterol. IL-1beta initiates a complex cascade of related immune responses. Interleukin Genetics' approach, started over fifteen years ago, is to study variations in regulatory, or on/off switch, regions for these first mover genes and then link them to biological events and risk of inflammatory disease.

Dr. Kenneth Kornman, Chief Scientific Officer at Interleukin Genetics and an author on the paper explained the practical utility of the IL1B genetic information. "We use a simple cheek swab to collect an individual's DNA. Our technologists perform the genetic analysis in our CLIA certified laboratory. A report is generated about an individual's risk for excess inflammation and cardiovascular disease. The privacy-ensured report is sent directly to the individual, who then has access to physicians and genetic counselors to discuss results."

These peer-reviewed results build on prior studies which showed that three gene variations inherited together from a parent, called a haplotype, functioned together to control regulation of the gene producing IL-1beta. In this study, four specific IL1B haplotype pairs, one from each parent, representing just over half of the study population, were associated with higher tissue levels of IL-1beta levels, and two of those haplotype pairs were also associated with increased blood CRP levels. CRP is an inflammatory chemical that is well-established as an independent marker of risk for heart disease.

Interleukin Genetics' Heart Health Genetic Test is available to consumers in the U.S. and Canada under the Gensona(R) brand and marketed by Alticor Inc. The Gensona(R) Heart Health Genetic Test employs a number of single nucleotide polymorphisms (genetic sequence variations called SNPs) to identify specific genetic patterns in the Interleukin 1 genes. These genetic patterns
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SOURCE Interleukin Genetics, Inc.
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